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DX . DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Dx.doi.org Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. CDN Services

We began analyzing https://elifesciences.org/articles/06567, but it redirected us to https://elifesciences.org/articles/06567. The analysis below is for the second page.

Title[redir]:
Spectrin regulates Hippo signaling by modulating cortical actomyosin activity | eLife
Description:
Organs including the liver, eyes, and lungs are made up of millions of cells, and how these organs stop growing once they reach their final size has fascinated scientists for decades. The cells in developing organs must communicate with each other and respond appropriately to the signals that they receive from other cells. This requires so-called “signaling pathways”. One such pathway that involves a protein called Hippo is known to control when cells should grow and divide and when they should stop. If this pathway does not work correctly, it can cause too many cells to be formed, which may result in cancer. The Hippo signaling pathway can also be regulated by an extensive network of protein filaments found within cells, called the cytoskeleton. This network can exert forces on the cells, which can have a major impact on cell growth. However, the mechanism behind the interaction between the cytoskeleton and the Hippo signaling pathway is poorly understood. Now, Deng et al. have engineered fruit flies in which the expression of individual genes had been artificially reduced, and looked for flies that had enlarged wings. Three genes identified in these experiments encode different subunits of a large spring-like protein, called spectrin, which is part of the cytoskeleton. This suggests that normally spectrin limits wing size. Furthermore, spectrin was also found to control the size of other organs in the fruit flies, such as the eyes and ovaries. In all of these organs, the Hippo signaling pathway failed to work properly in the absence of spectrin. Deng et al. then further explored the relationship between spectrin and Hippo signaling and found that cells without spectrin show abnormally high levels of tension in their cytoskeleton. When flies that lacked spectrin were engineered to reduce this tension, these flies developed normal sized organs. These findings reveal the importance of cytoskeleton tension in controlling tissue growth, and provide a new entry point to understand how normal tissues grow to their characteristic size and how such process goes awry in cancer.

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

What CMS is dx.doi.org built with?

Custom-built

No common CMS systems were detected on Dx.doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of dx.doi.org audience?

🌟 Strong Traffic: 100k - 200k visitors per month


Based on our best estimate, this website will receive around 100,868 visitors per month in the current month.

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How Does Dx.doi.org Make Money? {💸}

We can't see how the site brings in money.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Dx.doi.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

hippo, signaling, figure, spectrin, google, scholar, cell, αspec, pathway, cells, rnai, clones, cytoskeleton, actomyosin, biology, tubgal, drosophila, upstream, asset, mutant, pmlc, regulators, activity, protein, mer, membrane, download, growth, regulate, expression, httpsdoiorgelife, data, tension, kibra, increased, regulates, open, genes, control, tumor, molecular, sbms, supplement, hsflp, tissue, discs, marcm, uasgfp, article, development,

Topics {✒️}

tub-gal80 frt40a/frt40a uas-α-specrnai tub-gal80 frt40a/frt40a uas-β-specrnai tub-gal80 frt40a/frt40a uas-sghee tub-gal80 frt40a/frt40a exe1 yamamoto tub-gal80 frt40a/frt40a tub-gal4/ uas-α-specrnai uas-gfp/uas-α-specrnai tumour-suppressor genes nf2/merlin uas-βh-specrnai / uas-gfp uas-gfp hs-flp google scholar pan spectrin-myoii-mediated actomyosin activity wei wang department yonggang zheng department yun qing department salvador-warts-hippo pathway salvador-warts-hippo pathway gfp-positive marcm clones duojia pan department actomyosin-mediated cytoskeletal tension uas-βh-specrnai lines genome-wide rnai screen hippo tumor-suppressor pathway 50 µg/ml penicillin/streptomycin p-mlc signal revealed jianzhong yu department reducing α-spec led regulate p-mlc activity increased p-mlc level crosslinking short f-actin rok-myosin ii pathway facilitates spectrin-membrane assembly elevated p-mlc level α-specrg41 mutant clones wts/lats-independent mechanisms elevated p-mlc levels high p-mlc levels α-spec-deficient phenotypes entire apical–basal axis reducing α-spec expression sansores-garcia fat cadherin acts α-spec rnai showed anti-p-mlc antibody α-spec mutant phenotypes α-spec mutant tissues uas-α-specrnai human nonerythroid alpha-spectrin regulate downstream signaling

Questions {❓}

  • Despite these exciting progresses, important questions remain: what is the relationship between the actomyosin cytoskeleton and the other reported upstream regulators such as Kibra, Ex, and Mer in Hippo pathway regulation?

Schema {🗺️}

ScholarlyArticle:
      context:https://schema.org
      mainEntityOfPage:
         type:WebPage
         id:https://elifesciences.org/articles/06567
      headline:Spectrin regulates Hippo signaling by modulating cortical actomyosin activity
      datePublished:2015-03-31
      author:
            type:Person
            name:Hua Deng
            type:Person
            name:Wei Wang
            type:Person
            name:Jianzhong Yu
            type:Person
            name:Yonggang Zheng
            type:Person
            name:Yun Qing
            type:Person
            name:Duojia Pan
      publisher:
         type:Organization
         name:eLife Sciences Publications, Ltd
         logo:
            type:ImageObject
            url:https://elifesciences.org/assets/patterns/img/patterns/organisms/[email protected]
      keywords:
         organ size
         signal transduction
         cytoskeleton
         myosin activity
         cell tension
      about:
         Cell Biology
         Developmental Biology
      description:A contractile structural protein of the membrane-associated cytoskeleton is a Hippo signaling component that works through the regulation of non-muscle myosin activity in Drosophila.
      isPartOf:
         type:Periodical
         name:eLife
         issn:2050-084X
WebPage:
      id:https://elifesciences.org/articles/06567
Person:
      name:Hua Deng
      name:Wei Wang
      name:Jianzhong Yu
      name:Yonggang Zheng
      name:Yun Qing
      name:Duojia Pan
Organization:
      name:eLife Sciences Publications, Ltd
      logo:
         type:ImageObject
         url:https://elifesciences.org/assets/patterns/img/patterns/organisms/[email protected]
ImageObject:
      url:https://elifesciences.org/assets/patterns/img/patterns/organisms/[email protected]
Periodical:
      name:eLife
      issn:2050-084X

Social Networks {👍}(10)

External Links {🔗}(572)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Tag Manager

Libraries {📚}

  • Highcharts
  • PhotoSwipe

CDN Services {📦}

  • Cloudflare
  • Hypothes

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