
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Patient-derived xenograft models of breast cancer and their predictive power - PMC
Description:
Despite advances in the treatment of patients with early and metastatic breast cancer, mortality remains high due to intrinsic or acquired resistance to therapy. Increased understanding of the genomic landscape through massively parallel sequencing ...
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Keywords {🔍}
doi, cancer, breast, tumor, pubmed, google, scholar, models, pmc, pdx, article, tumors, free, patientderived, xenograft, primary, human, cell, cells, mice, expression, resistance, engraftment, xenografts, growth, nature, res, patients, clinical, treatment, genomic, patient, metastatic, mutations, pdxs, metastasis, luminal, metastases, subtypes, preclinical, drug, gene, triplenegative, stem, molecular, model, therapy, lines, response, analysis,
Topics {✒️}
severe combined immunodeficiency competing interests nod/scid/il2γ-receptor null nod/scid/il2rγc−/− phosphatidylinositol 3-kinase her2/erbb2-amplified pdx lines lactate dehydrogenase-elevating virus nonobese diabetic patient-derived xenograft models pi3k/akt/mtor signaling pathway breast-cancer-derived xenografts bone marrow-derived monocytes triple-negative breast cancer triple-negative breast cancers orthotopic patient-derived xenografts single base-pair substitutions esr1 ligand-binding domain hormone receptor-positive nonconditioned nod/scid mice functional intra-tumoral heterogeneity pmc beta search er-mediated gene transcription node-negative breast cancer late bevacizumab-induced responses er-positive breast cancer er-positive tumors retain long-established cell lines pi3k/akt/mtor pathway her2-amplified pdx models patient-derived xenograft triple-negative tumors owing er-positive pdx models secrete growth factors/cytokines er-positive model displaying patient-derived xenografts hormone receptor status androgen receptor inhibitors triple-negative tumors demonstrated bcl-2-expressing breast tumors patient-derived models inter-tumoral heterogeneity triple-negative cancer er-negative tumors benefit single nucleotide variants gene expression patterns large-scale parallel sequencing typically triple-negative rapamycin mtl integrating information based
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- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {📦}
- Ncbi