
DOI . ORG {
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Title[redir]:
Finding the tumor copycat: Therapy fails, patients don't | Nature Medicine
Description:
The complexity of human metastatic cancer is difficult to mimic in mouse models. As a consequence, seemingly successful studies in murine models do not translate into success in late phases of clinical trials, pouring money, time and people
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nature portfolio epha2/twist-ve-cadherin/akt pathway permissions reprints privacy policy advertising nature small-cell lung cancer social media patient-derived xenograft hyo-jeong leeΒ &Β eun human metastatic cancer personal data springerlink instant access data protection permissions privacy anderson cancer center explore content subscription content european economic area institutional subscriptions read accepting optional cookies journals search log manage preferences seemingly successful studies explain therapy failure content authors correspondence access pancreatic cancer translational medicine journal publish september 2010 finding issue learn article purchase institution subscribe institution buy article ellis cancer growth cancer res cancer biology mouse models murine models optional cookies preclinical evaluation bench article article cite choices essential cookies cookies skip
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headline:Finding the tumor copycat: Therapy fails, patients don't
description:The complexity of human metastatic cancer is difficult to mimic in mouse models. As a consequence, seemingly successful studies in murine models do not translate into success in late phases of clinical trials, pouring money, time and people's hope down the drain. In 'Bedside to Bench', Isaiah Fidler and Lee Ellis discuss crucial parameters in cancer growth and therapy and emphasize the disparity between studies in humans and mice. In 'Bench to Bedside', Terry Van Dyke shows how pancreatic tumors developed de novo in the organ site in mice can explain therapy failure in people with cancer and serve as a model to test new drugs.
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description:The complexity of human metastatic cancer is difficult to mimic in mouse models. As a consequence, seemingly successful studies in murine models do not translate into success in late phases of clinical trials, pouring money, time and people's hope down the drain. In 'Bedside to Bench', Isaiah Fidler and Lee Ellis discuss crucial parameters in cancer growth and therapy and emphasize the disparity between studies in humans and mice. In 'Bench to Bedside', Terry Van Dyke shows how pancreatic tumors developed de novo in the organ site in mice can explain therapy failure in people with cancer and serve as a model to test new drugs.
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