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We began analyzing https://www.nature.com/articles/nature01960, but it redirected us to https://www.nature.com/articles/nature01960. The analysis below is for the second page.

Title[redir]:
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan | Nature
Description:
In diverse organisms, calorie restriction slows the pace of ageing and increases maximum lifespan. In the budding yeast Saccharomyces cerevisiae, calorie restriction extends lifespan by increasing the activity of Sir2 (ref. 1), a member of the conserved sirtuin family of NAD+-dependent protein deacetylases2,3,4,5,6. Included in this family are SIR-2.1, a Caenorhabditis elegans enzyme that regulates lifespan7, and SIRT1, a human deacetylase that promotes cell survival by negatively regulating the p53 tumour suppressor8,9,10. Here we report the discovery of three classes of small molecules that activate sirtuins. We show that the potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan by 70%. We discuss possible evolutionary origins of this phenomenon and suggest new lines of research into the therapeutic use of sirtuin activators.

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article, scholar, google, cas, nature, sir, supplementary, pdf, cell, access, lifespan, sinclair, protein, research, content, yeast, ads, ageing, biomol, table, cookies, cerevisiae, bitterman, restriction, resveratrol, privacy, information, saccharomyces, calorie, family, naddependent, sirt, human, deacetylase, nad, open, guarente, usa, figure, data, howitz, cohen, zipkin, activity, silencing, acad, sci, medical, function, advertising,

Topics {✒️}

nature portfolio permissions reprints privacy policy advertising social media research scholar yeast longevity research author information authors nad-dependent protein deacetylases nad+-dependent protein deacetylases2 nature 403 nature 410 nature 423 nature nature 425 nad-dependent histone deacetylase nad-dependent p53 deacetylase 1-o-acetyl-adp-ribose aging research author correspondence stimulating sirt1-dependent deacetylation personal data li-li zhang research springerlink instant access data protection permissions harvard medical school putative negative regulator histone deacetylase families life-span extension paclitaxel-induced apoptosis harvard-armenise foundation privacy targeting nad metabolism transforming protein kinase increases maximum lifespan cancer chemopreventive activity issue learn promotes cell survival conserved regulatory mechanism conserved sirtuin family p53 tumour suppressor8 longevity protein sir2 european economic area institutional subscriptions read cyclic nucleotide-independent syk-selective inhibitor radical liposome oxidation extrachromosomal rdna circles

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Resveratrol: a molecule whose time has come?

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