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We began analyzing https://link.springer.com/article/10.1007/s10753-006-9012-0, but it redirected us to https://link.springer.com/article/10.1007/s10753-006-9012-0. The analysis below is for the second page.

Title[redir]:
Effects of Resveratrol in Inflammatory Arthritis | Inflammation
Description:
Nuclear factor kappa B (NF-κB), is a pivotal transcription factor involved in the activation of the TNF-α and IL-1β genes. Activation of NF-κB in synovial cells is a feature seen in arthritis patients. Resveratrol, a polyphenolic, natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-α and IL-1β induced NF-κB activation. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental rabbit inflammatory arthritis model. Arthritis was induced by intra-articular injection of three times of 50 μg lipopolysaccharide (LPS) at day 0, 4 and 8 at 4-day intervals into the knee joints of rabbits. To the test group, 10 μMol/kg resveratrol in the DMSO was injected in the knees at day 0 and then it was continued once daily for 2 weeks. To the control group the same time and amount of DMSO was injected the knees of rabbits. All rabbits were killed 1 week after the last injection and cartilage tissue and synovium were evaluated with semiquantitative scoring histologically. According to control group in the resveratrol group, significantly decreased cartilage destruction was determined by H&E staining (p = 0.04). Loss of matrix proteoglycan content in the cartilage was much lower, as determined by safranin O staining (p = 0.03). We also observed marked synovial inflammation after intra-articular injection to control knees, but not in the resveratrol treated group knees (p = 0.01). This study suggests that intra-articular injection of resveratrol may protect cartilage against the development of experimentally induced IA.

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Keywords {🔍}

article, google, scholar, cas, arthritis, pubmed, resveratrol, factor, activation, nuclear, intraarticular, cartilage, rheumatoid, content, inflammation, inflammatory, transcription, model, access, privacy, cookies, effects, synovial, cells, induced, group, human, van, activity, publish, search, elmali, nfκb, natural, inhibitor, synovium, injection, rabbits, knees, tissue, therapeutic, effect, collageninduced, chemopreventive, res, data, information, log, journal, research,

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month download article/chapter blocking nf-kappab inhibits transcription factor nf-kappa spares anti-inflammatory mediators repeated intra-articular injections intra-articular injected 3′-sialyllactose collagen-induced model full article pdf collagen-induced arthritis nuclear factor-interleukin-6 rheumatoid arthritis induced article inflammation aims human synovial cells nf-kb activation nuclear factor kappa privacy choices/manage cookies inflammatory arthritis published il-1β genes related subjects anti-inflammatory phytochemicals predictive genetic model defining therapeutic targets experimentally induced ia mc3t3-e1 cells intra-articular injections nf-κb arthritis patients systemic interleukin-4 treatment european economic area scope submit manuscript semiquantitative scoring histologically reactive oxygen intermediates s-phase arrest reactive oxygen species anticancer chemopreventive activity matrix proteoglycan content intra-articular injection natural phytoalexin found natural product derived coenen-de roo 10 μmol/kg resveratrol conditions privacy policy van den berg subcutaneous tnf inhibitor key regulator tissue resveratrol concentrations van de geest cancer chemopreventive activity van de loo check access

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