
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Next-Generation Sequencing: A powerful tool for the discovery of molecular markers in breast ductal carcinoma in situ - PMC
Description:
Mammographic screening leads to frequent biopsies and concomitant overdiagnosis of breast cancer, particularly ductal carcinoma in situ (DCIS). Some DCIS lesions rapidly progress to invasive carcinoma whereas others remain indolent. Because we ...
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Keywords {๐}
doi, breast, cancer, dcis, google, scholar, pubmed, expression, carcinoma, pmc, article, free, progression, situ, ductal, gene, molecular, clinical, analysis, lesions, invasive, idc, models, ngs, human, journal, screening, sequencing, genes, study, patients, cells, nature, cell, data, markers, model, risk, res, profiling, biomarkers, research, disease, mutations, genome, subtypes, studies, mammary, approaches, treatment,
Topics {โ๏ธ}
nod-scid il-2rgamma null patient-calibrated agent-based modelling formalin-fixed paraffin-embedded pmc beta search transforming growth factor-beta triple-negative breast cancer whey-acid protein promoter c-myc-amplified breast carcinomas laser capture micro-dissection tamoxifen-resistant breast cancer node-negative breast cancer serum genome-wide micrornas 4d live-cell imaging multi-component dysregulated pathways integrated data-mining platform mammographically-detected breast cancers modestly reduces mortality high-grade molecular pathway identifying chip-seq enrichment chip-seq experiments relative large-scale randomized trials inducing epithelial-mesenchymal transition united states government exon-level transcriptome profiling patient-specific signaling networks long-term follow high throughput manner identified distinct driver-networks quantify nucleic acids publisher site pdf low-grade molecular pathway high-throughput screening [google scholar] 18 [google scholar] 21 cancer cells grown comedo-type dcis primary human cells low-grade molecular subtype multiple collaborative teams mammary fat pads inter-chromosomal rearrangements [132] ๏ฟฝmultiple mapping readsโ factor binding sites high-grade variety final edited form extracellular matrix pathways protein-protein interactions progression-specific genes identified nat rev genet natl cancer inst
Questions {โ}
- Breast cancer screening: are we seeing the benefit?
- Columnar cell lesions of the breast: the missing link in breast cancer progression?
- Is contralateral prophylactic mastectomy (CPM) overused?
- What is the malignant nature of human ductal carcinoma in situ?
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- How much money does https://scholar.google.com/scholar_lookup?journal=Nature%20protocols&title=Identifying%20ChIP-seq%20enrichment%20using%20MACS&author=J%20Feng&author=T%20Liu&author=B%20Qin&author=Y%20Zhang&author=XS%20Liu&volume=7&issue=9&publication_year=2012&pages=1728-1740&pmid=22936215&doi=10.1038/nprot.2012.101& generate?
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