DOI . ORG {
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We began analyzing https://www.annualreviews.org/content/journals/10.1146/annurev.pathmechdis.3.121806.151526, but it redirected us to https://www.annualreviews.org/content/journals/10.1146/annurev.pathmechdis.3.121806.151526. The analysis below is for the second page.
Title[redir]:
Modeling Morphogenesis and Oncogenesis in Three-Dimensional Breast Epithelial Cultures | Annual Reviews
Description:
Three-dimensional (3D) epithelial culture systems recreate the cardinal features of glandular epithelium in vivo and represent a valuable tool for modeling breast cancer initiation and progression in a structurally appropriate context. 3D models have emerged as a powerful method to interrogate the biological activities of cancer genes and oncogenic pathways, and recent studies have poignantly illustrated their utility in dissecting the emerging role of tensional force in regulating epithelial tissue homeostasis. We review how 3D models are being used to investigate fundamental cellular and biophysical mechanisms associated with breast cancer progression that have not been readily amenable to traditional genetic or biochemical analysis.
Title[redir]:
Modeling Morphogenesis and Oncogenesis in Three-Dimensional Breast Epithelial Cultures | Annual Reviews
Description:
Three-dimensional (3D) epithelial culture systems recreate the cardinal features of glandular epithelium in vivo and represent a valuable tool for modeling breast cancer initiation and progression in a structurally appropriate context. 3D models have emerged as a powerful method to interrogate the biological activities of cancer genes and oncogenic pathways, and recent studies have poignantly illustrated their utility in dissecting the emerging role of tensional force in regulating epithelial tissue homeostasis. We review how 3D models are being used to investigate fundamental cellular and biophysical mechanisms associated with breast cancer progression that have not been readily amenable to traditional genetic or biochemical analysis.
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Keywords {🔍}
annual, vol, article, cancer, review, mechanisms, reviews, institutional, disease, volume, breast, epithelial, contact, usage, content, login, publications, journal, subscribe, pathology, modeling, threedimensional, publication, info, share, progression, models, biological, force, cited, impact, knowable, magazine, news, charleston, advisor, grain, copyright, cookies, track, preferencesi, understand, skip, register, cart, information, give, home, morphogenesis, oncogenesis,
Topics {✒️}
annual reviews read annual reviews news careers contact clinical impact breast cancer progression track usage investigate fundamental cellular pierre-yves desprez resistance sreya bagchi submission editorial principles judith campisi vol disease relevance marcia cited rss feed article preparation preferences discover content policies contact publications a journal information disease volume 3 cancer genes sinclair vol engleman vol friedman vol croce vol journals a grain libraries understand skip cardinal features glandular epithelium valuable tool powerful method biological activities oncogenic pathways recent studies poignantly illustrated emerging role readily amenable traditional genetic biochemical analysis apicobasal polarity lumen formation secretory phenotype dark side ana krtolica 99–118 mammalian sirtuins biological insights robert yuan michela garofalo related articles
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