
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Nucleic Acid Sensors and Type I Interferon Production in Systemic Lupus Erythematosus - PMC
Description:
The characteristic serologic feature of systemic lupus erythematosus (SLE) is autoantibodies against oneβs own nucleic acid or nucleic acid-binding proteins β DNA and RNA-binding nuclear proteins. Circulating autoantibodies can deposit in the ...
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Keywords {π}
doi, pubmed, google, scholar, lupus, pmc, article, free, sle, systemic, dna, erythematosus, type, immune, signaling, tlr, ifn, cells, rna, nucleic, irf, genetic, activation, immunol, acid, cell, receptors, production, responses, tolllike, pathway, rigi, interferon, domain, patients, receptor, nat, sensors, niewold, autoantibodies, innate, complexes, disease, pathways, cytosolic, gene, inflammasome, nature, cytokines, factors,
Topics {βοΈ}
genome-wide association scan interferon-inducible ifi200-family genes virus-triggered ifn-beta signaling double-stranded ribonucleic acids autoimmune small-vessel vasculitis pmc beta search dexd/h-box helicase rig-i-mediated antiviral responses serum interferon-alpha activity free nucleic acid cytosolic dna-sensing machinery multi-protein inflammasome complex atm-dependent dna-damage high serum ifn-Ξ± retinoic acid-inducible gene pro-inflammatory cytokines il-1Ξ² rna virus-induced responses adaptor inducing ifn-Ξ² nonself rna-sensing mechanism interferon alpha-induced lupus activate anti-viral responses nucleic acid-protein complexes preventing cell-intrinsic initiation c-terminal regulatory domain il-1Ξ² converting enzyme dominant aicardi-goutieres syndrome negative-strand rna virus gene-expression-guided selection viral/bacterial nucleic acid interferon-dependent immune responses c-terminal repressor domain african-derived genetic polymorphisms chromatin-igg complexes activate unlike membrane-bound tlrs dnase-ii knockout mice mouse embryos deficient publisher site pdf induce pro-inflammatory responses interferon-dependent innate immunity antigen-specific antibody response post-translational levels aim2-related protein ifi16 rna-binding nuclear proteins multiple ancestral groups double-stranded dna double-stranded rna tlr-dependent ifnΞ± pathway rare dnase-iii mutations single-stranded rna engulfed apoptotic/necrotic cells
Questions {β}
- How Does Lupus Start?
Social Networks {π}(6)
External Links {π}(254)
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- How much money does https://scholar.google.com/scholar_lookup?journal=Nat%20Immunol&title=IPS-1,%20an%20adaptor%20triggering%20RIG-I-%20and%20Mda5-mediated%20type%20I%20interferon%20induction&author=T%20Kawai&author=K%20Takahashi&author=S%20Sato&author=C%20Coban&author=H%20Kumar&volume=6&issue=10&publication_year=2005&pages=981-8&pmid=16127453&doi=10.1038/ni1243& generate?
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