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We began analyzing https://www.nature.com/articles/ni.1864, but it redirected us to https://www.nature.com/articles/ni.1864. The analysis below is for the second page.

Title[redir]:
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses | Nature Immunology
Description:
The AIM2 inflammasome induces maturation of the proinflammatory cytokines IL-1β and IL-18. Using AIM2-deficient mice, Fitzgerald and colleagues and Alnemri and colleagues show that the AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-1β) and IL-18. AIM2 has been shown to bind DNA and engage the caspase-1-activating adaptor protein ASC to form a caspase-1-activating inflammasome. Using Aim2-deficient mice, we identify a central role for AIM2 in regulating caspase-1-dependent maturation of IL-1β and IL-18, as well as pyroptosis, in response to synthetic double-stranded DNA. AIM2 was essential for inflammasome activation in response to Francisella tularensis, vaccinia virus and mouse cytomegalovirus and had a partial role in the sensing of Listeria monocytogenes. Moreover, production of IL-18 and natural killer cell–dependent production of interferon-γ, events critical in the early control of virus replication, were dependent on AIM2 during mouse cytomegalovirus infection in vivo. Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity.

Matching Content Categories {📚}

  • Education
  • Science
  • Telecommunications

Content Management System {📝}

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Custom-built

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🌠 Phenomenal Traffic: 5M - 10M visitors per month


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Keywords {🔍}

pubmed, article, google, scholar, cas, nature, inflammasome, immunol, aim, response, central, innate, activation, cell, university, infection, immunity, dna, francisella, receptor, signaling, tularensis, virus, access, nat, content, interleukin, mice, immunology, host, caspase, essential, cookies, cytosolic, mouse, cytomegalovirus, exp, massachusetts, vakr, privacy, waggoner, latz, inflammasomes, natural, killer, cells, recognition, rna, rev, immune,

Topics {✒️}

nature portfolio permissions reprints privacy policy research england regional center advertising social media il-10-induced anti-inflammatory response author information authors nature 448 nature 458 nature nature 440 nature 461 author correspondence synthetic double-stranded dna personal data springerlink instant access data protection tbk1-irf-3 signaling axis regulating caspase-1-dependent maturation permissions inhibit host inflammatory interferon-dependent innate immunity c-type lectin superfamily listeria monocytogenes infection sivapriya kailasan vanaja macrophage proinflammatory response reduced inflammatory response dendritic cells challenged innate immune response privacy cell death differ gene-trap integration competing financial interests rig-i-dependent sensing caspase-1-activating inflammasome eicke latz & katherine bacterial molecules activates caspase-1 activation induced gene-targeted mice family rna helicases francisella tularensis infection asc/caspase-1 axis innate immune detection innate immune pathways interleukin-1 beta encoded triggering innate immunity antiviral innate immunity listeria monocytogenes

Questions {❓}

  • The HIN-200 family: more than interferon-inducible genes?

Schema {🗺️}

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         datePublished:2010-03-28T00:00:00Z
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            type:Organization
            name:Institute of Clinical Chemistry and Pharmacology, University of Bonn
            address:
               name:Institute of Clinical Chemistry and Pharmacology, University of Bonn, Germany
               type:PostalAddress
            type:Organization
      name:Veit Hornung
      affiliation:
            name:Institute of Clinical Chemistry and Pharmacology, University of Bonn
            address:
               name:Institute of Clinical Chemistry and Pharmacology, University of Bonn, Germany
               type:PostalAddress
            type:Organization
      name:Stefanie N Vogel
      affiliation:
            name:University of Maryland, Baltimore
            address:
               name:Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, USA
               type:PostalAddress
            type:Organization
      name:Eva Szomolanyi-Tsuda
      affiliation:
            name:University of Massachusetts Medical School
            address:
               name:Department of Pathology, University of Massachusetts Medical School, Worcester, USA
               type:PostalAddress
            type:Organization
      name:Katherine A Fitzgerald
      affiliation:
            name:Division of Infectious Diseases and Immunology, Department of Medicine
            address:
               name:Division of Infectious Diseases and Immunology, Department of Medicine,
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Infectious Diseases and Immunology, Department of Medicine,
      name:Division of Infectious Diseases and Immunology, Department of Medicine,
      name:Department of Pathology, University of Massachusetts Medical School, Worcester, USA
      name:Division of Infectious Diseases and Immunology, Department of Medicine,
      name:Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, USA
      name:Division of Infectious Diseases and Immunology, Department of Medicine,
      name:Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, USA
      name:Division of Infectious Diseases and Immunology, Department of Medicine,
      name:Division of Infectious Diseases and Immunology, Department of Medicine,
      name:Division of Infectious Diseases and Immunology, Department of Medicine,
      name:Institute of Clinical Chemistry and Pharmacology, University of Bonn, Germany
      name:Institute of Clinical Chemistry and Pharmacology, University of Bonn, Germany
      name:Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, USA
      name:Department of Pathology, University of Massachusetts Medical School, Worcester, USA
      name:Division of Infectious Diseases and Immunology, Department of Medicine,
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