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Title[redir]:
Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes - PMC
Description:
Inflammasomes are multiprotein complexes that recognize pathogens and pathogen- or danger-associated molecular patterns. They induce the maturation and secretion of powerful proinflammatory interleukin-1B (IL-1β), IL-18, and IL-33 cytokines, which ...
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Keywords {🔍}
ifi, hsv, infection, cells, fig, inflammasome, doi, google, scholar, pubmed, nlrp, infected, asc, pmc, activation, article, ilβ, free, virus, icp, cell, protein, actin, dna, viral, hff, levels, degradation, caspase, herpes, simplex, arrows, expression, aim, western, induces, analysis, mock, virol, proteins, early, genome, cytoplasm, antibodies, kshv, colocalization, shown, studies, immunofluorescence, nuclear,
Topics {✒️}
alexa fluor-conjugated phalloidin alexa fluor-conjugated streptavidin pmc beta search recombinant varicella-zoster virus total pro-il-1β levels e2 ubiquitin-conjugating enzymes ring-type ubiquitin ligases turn cleaves prointerleukin-1β human interferon-inducible protein quantitative real-time pcr tumor necrosis factor-alpha protein g-sepharose beads pmc copyright notice human monocyte-derived macrophages herpes simplex virus blocking ifn-beta induction dna-dependent protein kinase host/hsv-1 factors activates il-1β transiently associates unknown hsv-1-encoded mechanism interferon-inducible ifi16 protein interferon-inducible protein ifi16 il-1β levels increased hsv-1-induced chemokine expression activates il-1β activation inhibit il-1β release stimulate ifn-β expression serum-free dmem inhibit il-1β secretion stimulate il-1β maturation prevent il-1β cleavage alphaherpesvirus us3 kinase ifi16-sting signaling pathway cytoplasmic cellular stress e3 ubiquitin ligases powerful proinflammatory interleukin-1b hsv-1-induced cell death biologically active il-1β detected elevated il-1β induce il-1β cleavage hsv-1-mediated inflammasome suppression e3 ubiquitin ligase interferon-inducible autoantigen encephalomyocarditis virus infection ubiquitin-conjugating enzyme nlrp3/ifi16 inflammasome activity hsv-1 infection-induced activation syk tyrosine kinase monocyte-derived macrophages p53-mediated apoptosis pathway
Questions {❓}
- NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
- The HIN-200 family: more than interferon-inducible genes?
- The NLRP3 inflammasome: a sensor for metabolic danger?
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- Check the income stats for https://doi.org/10.1006/viro.1993.1612
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- See how much https://scholar.google.com/scholar_lookup?journal=J.%20Virol.&title=Herpes%20simplex%20virus%20ICP0%20promotes%20both%20histone%20removal%20and%20acetylation%20on%20viral%20DNA%20during%20lytic%20infection&author=AR%20Cliffe&author=DM%20Knipe&volume=82&publication_year=2008&pages=12030-12038&pmid=18842720&doi=10.1128/JVI.01575-08& makes per month
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