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We began analyzing https://www.nature.com/articles/1204005, but it redirected us to https://www.nature.com/articles/1204005. The analysis below is for the second page.

Title[redir]:
Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16 | Oncogene
Description:
Interferons are important in regulating cell growth and differentiation, immune function and initiating anti-viral responses. While the pleotrophic actions of interferons have been well documented, the molecular mechanisms underpinning their biological effects have not been fully characterized. IFI 16 is a member of the interferon-inducible HIN-200 family of nuclear proteins, which we have recently shown can function as a potent transcriptional repressor. A murine member of the HIN-200 family, p202, can indirectly interact with p53 via the p53 binding protein (p53bp) and inhibit p53-mediated transcriptional activation. The binding activity of p202 to p53bp was shown to require the conserved MFHATVAT motif present in all 200 amino acid repeat regions of HIN-200 proteins. Given that IFI 16 contains two MFHATVAT motifs, we sought to determine whether IFI 16 may form a complex with p53 and if so to ascertain the functional significance of this interaction. We demonstrate that IFI 16 can directly bind to the C-terminal region of p53 and augment p53-mediated transcriptional activation without altering the steady state levels of p53. Thus, in addition to its ability to directly regulate gene expression, IFI 16 can also modulate the transcription function of other cellular transcription factors. These findings demonstrate a possible link between gene induction following interferon stimulation and p53-mediated cellular events.

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Keywords {🔍}

cell, nature, biol, oncogene, ifi, trapani, access, article, choubey, lengyel, content, johnstone, research, cookies, chem, res, privacy, open, briggs, biochem, mol, gutterman, embo, wang, function, data, interaction, interferon, datta, dawson, biophys, gariglio, landolfo, cancer, advertising, information, journal, subscribe, december, functional, interferoninducible, wei, greenway, growth, molecular, hin, family, transcriptional, pmediated, activation,

Topics {✒️}

nature portfolio permissions reprints privacy policy principal research fellow author information authors 1996 nature 382 1992 nature 357 nature medical research council advertising social media east melbourne medical research p53-mediated cellular events promotes e2-dependent growth initiating anti-viral responses multidrug transporter p-glycoprotein personal data interferon-inducible hin-200 family springerlink instant access data protection cellular transcription factors permissions lee j chromatin-bound ifi16 steady state levels privacy potent transcriptional repressor issue learn mutant p53 cells explore content subscription content european economic area institutional subscriptions read el-deiry ws smorgon family building st andrews place macfarlane burnet centre yarra bend road nutlin-3-induced redistribution accepting optional cookies regulating cell growth p53 binding protein interferon cytokine res molecular mechanisms underpinning molecular life sciences journals search log nuclear proteins c-terminal region woodchuck hepatitis virus

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