NCBI . NLM . NIH . GOV {
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We began analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC3043090/, but it redirected us to https://pmc.ncbi.nlm.nih.gov/articles/PMC3043090/. The analysis below is for the second page.
Title[redir]:
The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans - PMC
Description:
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn
Title[redir]:
The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans - PMC
Description:
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn
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Keywords {🔍}
cells, ilr, doi, group, mrna, ila, pubmed, google, scholar, expression, gene, fig, variant, response, cell, cytokine, ilβpolarized, production, donors, data, human, cytometry, psoriasis, red, effector, shown, snp, flow, percentage, green, pmc, protective, test, ilinduced, effect, differentiation, analysis, study, performed, culture, compared, allele, differ, article, disease, significantly, functional, mfi, inflammation, results,
Topics {✒️}
ccr6+il-23r+ il-1β-polarized cells il-1β/il-23-polarized th17 cells mabs targeting il-12/il-23p40 anti-cd3/cd28 coated beads anti-cd3/cd28 coated-beads anti-il-12/il-23p40 mab il-1β-polarized th17 cells il-1β/il-23-polarized cells pstat-3 il-1β-polarized cells lineage–defining cytokine il-17a affect il-23/il-23r signalling transforming growth factor-beta il-23/il-23r signalling plays immune-targeted drug therapy il-23r+ccr6+ th17 cells il-1β-polarized cells il-23-induced tissue pathologies multiple immune-mediated diseases recombinant human il-1β pmc beta search il-23-induced stat phosphorylation il-6-induced stat-3 phosphorylation human immune-mediated diseases il-23-induced th17 differentiation immune-mediated chronic inflammation il-23r subunit paired il-12rβ1 subunit shared cell-mediated intestinal inflammation il-23-dependent gene expression genome-wide association studies cost-effective clinical trials il-23r+th17 cells cells expressing il-23r il-23/il-23r signaling il-23/th17 cells axis il23r+ccr6+ th17 cells common il-12p40 subunit cd3+cd4+cd45ro+ cells net il-17a production il-23r expression showed short-term il-23 stimulation il-23/il-23r axis il-17a mrna levels cd3+cd4+cells determined detectable il-17a response cell–free supernatant primary human cells il-23r complex leads il-17a mrna expression cd4+cd45ra+cd45ro− naïve
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