Here's how DOI.ORG makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

DOI . ORG {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Doi.org Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. Social Networks
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. Hosting Providers
  14. CDN Services

We began analyzing https://www.nature.com/articles/ni.1610, but it redirected us to https://www.nature.com/articles/ni.1610. The analysis below is for the second page.

Title[redir]:
The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt | Nature Immunology
Description:
TH-17 cells are interleukin 17 (IL-17)–secreting CD4+ T helper cells involved in autoimmune disease and mucosal immunity. In naive CD4+ T cells from mice, IL-17 is expressed in response to a combination of IL-6 or IL-21 and transforming growth factor-β (TGF-β) and requires induction of the nuclear receptor RORγt. It has been suggested that the differentiation of human TH-17 cells is independent of TGF-β and thus differs fundamentally from that in mice. We show here that TGF-β, IL-1β and IL-6, IL-21 or IL-23 in serum-free conditions were necessary and sufficient to induce IL-17 expression in naive human CD4+ T cells from cord blood. TGF-β upregulated RORγt expression but simultaneously inhibited its ability to induce IL-17 expression. Inflammatory cytokines relieved this inhibition and increased RORγt-directed IL-17 expression. Other gene products detected in TH-17 cells after RORγt induction included the chemokine receptor CCR6, the IL-23 receptor, IL-17F and IL-26. Our studies identify RORγt as having a central function in the differentiation of human TH-17 cells from naive CD4+ T cells and suggest that similar cytokine pathways are involved in this process in mice and humans.

Matching Content Categories {📚}

  • Science
  • Education
  • Business & Finance

Content Management System {📝}

What CMS is doi.org built with?

Custom-built

No common CMS systems were detected on Doi.org, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of doi.org audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Doi.org Make Money? {💸}

We can't tell how the site generates income.

Earning money isn't the goal of every website; some are designed to offer support or promote social causes. People have different reasons for creating websites. This might be one such reason. Doi.org could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, article, google, scholar, cas, cells, nature, human, immunol, interleukin, central, receptor, differentiation, cell, york, nat, cytokine, access, transforming, growth, littman, helper, tgfβ, med, content, rorγt, inflammatory, ilr, production, function, factorβ, induction, disease, immunity, cookies, nuclear, dan, expression, medicine, privacy, immunology, autoimmune, naive, mice, gene, exp, proinflammatory, usa, institute, data,

Topics {✒️}

cancer research institute nature portfolio permissions reprints privacy policy transforming growth factor-β–dependent advertising social media central nervous system-infiltrating transforming growth factor-β transforming growth factor-beta author information authors nature 445 nature 441 nature 448 nature modular tyrosine-based motifs t-cell receptor diversity data protection t-cell receptor stimulation author correspondence nf-κb signal pathway bearing ccr2+ccr5− phenotype personal data springerlink instant access development nuclear receptor rorγt serum-free conditions permissions il-23-mediated il-17 production 17 cell–mediated pathology naive human cd4+foxp3− cell receptor ligation promote interleukin-17 production inflammatory cytokines relieved cell differentiation mediated similar cytokine pathways privacy th17 cell differentiation article manel require tgf-β inflammatory bowel disease terminal ileum mediated stat3-dependent manner studies identify rorγt chemokine receptor ccr6 receptor-activated monocytes induce il-17 expression il-23/th17 axis il-26+ th17 intermediates cytokine receptor subunit

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
         description:TH-17 cells are interleukin 17 (IL-17)–secreting CD4+ T helper cells involved in autoimmune disease and mucosal immunity. In naive CD4+ T cells from mice, IL-17 is expressed in response to a combination of IL-6 or IL-21 and transforming growth factor-β (TGF-β) and requires induction of the nuclear receptor RORγt. It has been suggested that the differentiation of human TH-17 cells is independent of TGF-β and thus differs fundamentally from that in mice. We show here that TGF-β, IL-1β and IL-6, IL-21 or IL-23 in serum-free conditions were necessary and sufficient to induce IL-17 expression in naive human CD4+ T cells from cord blood. TGF-β upregulated RORγt expression but simultaneously inhibited its ability to induce IL-17 expression. Inflammatory cytokines relieved this inhibition and increased RORγt-directed IL-17 expression. Other gene products detected in TH-17 cells after RORγt induction included the chemokine receptor CCR6, the IL-23 receptor, IL-17F and IL-26. Our studies identify RORγt as having a central function in the differentiation of human TH-17 cells from naive CD4+ T cells and suggest that similar cytokine pathways are involved in this process in mice and humans.
         datePublished:2008-05-04T00:00:00Z
         dateModified:2008-05-04T00:00:00Z
         pageStart:641
         pageEnd:649
         sameAs:https://doi.org/10.1038/ni.1610
         keywords:
            Biomedicine
            general
            Immunology
            Infectious Diseases
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig5_HTML.jpg
         isPartOf:
            name:Nature Immunology
            issn:
               1529-2916
               1529-2908
            volumeNumber:9
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Nicolas Manel
               affiliation:
                     name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
                     address:
                        name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Derya Unutmaz
               affiliation:
                     name:New York University School of Medicine
                     address:
                        name:Department of Microbiology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dan R Littman
               affiliation:
                     name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
                     address:
                        name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:New York University School of Medicine
                     address:
                        name:Department of Microbiology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:Howard Hughes Medical Institute, New York University School of Medicine
                     address:
                        name:Howard Hughes Medical Institute, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
                     name:New York University School of Medicine
                     address:
                        name:Department of Pathology, New York University School of Medicine, New York, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
      description:TH-17 cells are interleukin 17 (IL-17)–secreting CD4+ T helper cells involved in autoimmune disease and mucosal immunity. In naive CD4+ T cells from mice, IL-17 is expressed in response to a combination of IL-6 or IL-21 and transforming growth factor-β (TGF-β) and requires induction of the nuclear receptor RORγt. It has been suggested that the differentiation of human TH-17 cells is independent of TGF-β and thus differs fundamentally from that in mice. We show here that TGF-β, IL-1β and IL-6, IL-21 or IL-23 in serum-free conditions were necessary and sufficient to induce IL-17 expression in naive human CD4+ T cells from cord blood. TGF-β upregulated RORγt expression but simultaneously inhibited its ability to induce IL-17 expression. Inflammatory cytokines relieved this inhibition and increased RORγt-directed IL-17 expression. Other gene products detected in TH-17 cells after RORγt induction included the chemokine receptor CCR6, the IL-23 receptor, IL-17F and IL-26. Our studies identify RORγt as having a central function in the differentiation of human TH-17 cells from naive CD4+ T cells and suggest that similar cytokine pathways are involved in this process in mice and humans.
      datePublished:2008-05-04T00:00:00Z
      dateModified:2008-05-04T00:00:00Z
      pageStart:641
      pageEnd:649
      sameAs:https://doi.org/10.1038/ni.1610
      keywords:
         Biomedicine
         general
         Immunology
         Infectious Diseases
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fni.1610/MediaObjects/41590_2008_Article_BFni1610_Fig5_HTML.jpg
      isPartOf:
         name:Nature Immunology
         issn:
            1529-2916
            1529-2908
         volumeNumber:9
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Nicolas Manel
            affiliation:
                  name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
                  address:
                     name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Derya Unutmaz
            affiliation:
                  name:New York University School of Medicine
                  address:
                     name:Department of Microbiology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dan R Littman
            affiliation:
                  name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
                  address:
                     name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:New York University School of Medicine
                  address:
                     name:Department of Microbiology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:Howard Hughes Medical Institute, New York University School of Medicine
                  address:
                     name:Howard Hughes Medical Institute, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
                  name:New York University School of Medicine
                  address:
                     name:Department of Pathology, New York University School of Medicine, New York, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Immunology
      issn:
         1529-2916
         1529-2908
      volumeNumber:9
Organization:
      name:Nature Publishing Group US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
      address:
         name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Microbiology, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
      address:
         name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Microbiology, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:Howard Hughes Medical Institute, New York University School of Medicine
      address:
         name:Howard Hughes Medical Institute, New York University School of Medicine, New York, USA
         type:PostalAddress
      name:New York University School of Medicine
      address:
         name:Department of Pathology, New York University School of Medicine, New York, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Nicolas Manel
      affiliation:
            name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
            address:
               name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Derya Unutmaz
      affiliation:
            name:New York University School of Medicine
            address:
               name:Department of Microbiology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      name:Dan R Littman
      affiliation:
            name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine
            address:
               name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:New York University School of Medicine
            address:
               name:Department of Microbiology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:Howard Hughes Medical Institute, New York University School of Medicine
            address:
               name:Howard Hughes Medical Institute, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
            name:New York University School of Medicine
            address:
               name:Department of Pathology, New York University School of Medicine, New York, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
      name:Department of Microbiology, New York University School of Medicine, New York, USA
      name:The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, USA
      name:Department of Microbiology, New York University School of Medicine, New York, USA
      name:Howard Hughes Medical Institute, New York University School of Medicine, New York, USA
      name:Department of Pathology, New York University School of Medicine, New York, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(1)

External Links {🔗}(320)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mx.zoho.eu
  • mx2.zoho.eu
  • mx3.zoho.eu

Name Servers:

  • josh.ns.cloudflare.com
  • zita.ns.cloudflare.com

CDN Services {📦}

  • Crossref

4.78s.