
NCBI . NLM . NIH . GOV {
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Title[redir]:
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged - PMC
Description:
Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of gene control in humans. It provides cells with the opportunity to create protein isoforms of differing, even opposing, functions from a single gene. ...
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Keywords {🔍}
pubmed, google, scholar, doi, splicing, cancer, cell, pmc, article, free, hnrnp, cells, proteins, protein, expression, exon, regulation, alternative, isoform, apoptosis, biol, role, inclusion, growth, tumor, important, srsf, mol, shown, ptb, production, genes, mrna, fas, binding, premrna, factor, wang, increased, gene, splice, receptor, promote, kinase, res, proliferation, function, rbm, rbps, activation,
Topics {✒️}
short-lived nonsense-mediated decay heterogeneous nuclear ribonucleoprotein-a2/b1 arginine/serine-rich splicing factors wnt/β-catenin pathway resulted fas-activated serine/threonine kinase wnt/β-catenin pathway appears ras–raf–mek–erk pathway polypyrimidine tract-binding protein polypyrimidine-tract-binding protein epithelial cell-type-specific regulators t-cell intracellular antigen-1 pmc beta search nonsense-mediated mrna decay erk map-kinase pathway gtp/gdp-binding status extremely short-lived mrna tissue slide-based selex serine/threonine phosphatases pp1 β-catenin negatively correlated transforming nih-3t3 fibroblasts del gatto-konczak covalent histone modifications—miswritten embryonic-lethal abnormal vision full-length h-ras transforming growth factor-β1 increased gdp/gtp exchange region immediately c-terminal rna-binding nuclear protein lopez de silanes cell cycle-dependent manner epithelial marker e-cadherin serine/arginine-rich camp-dependent pka phosphorylation bind au-rich elements transforming nih-3t3 cells splicing factor sf2/asf u-rich sequences downstream transform nih-3t3 cells c-rich signature motif δ-ron-specific sirnas uv-irradiated hela cells common full-length variant footnotes article full-length fas mrna multifunctional rna-binding protein nih-3t3 cells resulted fgfr2 iiib-expressing cells epithelial-specific splicing factors rna-binding protein tia-1 extensive stem–loop structure
Questions {❓}
- Alternative splicing in cancer: Noise, functional, or systematic?
- Caspase 2 in apoptosis, the DNA damage response and tumour suppression: Enigma no more?
- Caspase-2: Controversial killer or checkpoint controller?
- Given the association with cancer, what are the biological functions of RBM5?
- How do proliferating cells reprogram their metabolism to engage in aerobic glycolysis?
- How does what appears to be a minor modification in VEGF result in such drastically different properties?
- The spliceosome must be guided to the correct splice sites, so what determines which sequences will be included in the mRNA, and which will be excised and degraded in the nucleus?
- VEGF-A splicing: The key to anti-angiogenic therapeutics?
- What is the function of IDX inclusion?
- Why do tumor cells forsake the efficient extraction of energy from glucose, instead opting for high glucose consumption and high glycolytic flux?
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- How much does https://doi.org/10.1016/j.cell.2009.06.016 earn?
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