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Keywords {🔍}

mice, tau, caffeine, water, cells, type, wild, monthold, slices, full, doi, text, google, scholar, crossref, abstract, pubmed, exposure, caffeinetreated, months, frequency, figures, early, life, exposed, memory, amplitude, compared, figure, cognitive, maze, development, pregnancy, brain, time, found, increase, deficits, pathology, increased, pyramidal, gabaergic, animals, offspring, received, day, min, hippocampal, effects, mouse,

Topics {✒️}

data availability statement ethics statement open-access article distributed variables tau-caffeine-age interact aix-marseille university chancellor eden mother-child cohort thy-tau22 transgenic mice inhibitory post-synaptic currents reference housekeeping gene mother–child pairs showed diet-induced obesity onspathology hrp-conjugated secondary antibodies avoid intra-maze odor dose-response meta-analysis miniature/spontaneous epsc/ipsc ratios ad-related memory impairments wild type caffeine-treated gfp-expressing inhibitory neurons sample kolmogorov–smirnov test adenosine receptor ontogeny object-location memory task abnormally-phosphorylated tau proteins treating stress-induced vulnerability post-migration cortical connectivity tau caffeine-treated mice early-life risk factors research search frontiers thy-tau22 mice aix-marseille university hippocampus-dependent memory function action potential-dependent events thy-tau22 model thy-tau22 animals lifestyle-related factors alter spatial memory memory impairments occurring inter-event interval distribution hippocampal neuroinflammatory markers wt mice exposed numerous false positives synaptic inputs received inhibitory inputs received cumulative probability distributions early life produces van der jeugd wild type controls wild type counterparts tau caffeine-treated related neurological disorders kolmogorov–smirnov test

Questions {❓}

• At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby?

Schema {🗺️}

ScholarlyArticle:
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      headline:Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy
      author:
            type:Person
            name:Stefania Zappettini
            affiliation:
               Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, France
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            affiliation:
               Inserm, CHU Lille, LabEx DISTALZ, UMR-S 1172 - JPArc, Université de Lille, France
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            name:Antoine Ghestem
            affiliation:
               Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, France
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            type:Person
            name:Monique Esclapez
            affiliation:
               Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, France
            type:Person
            name:Christophe Bernard
            affiliation:
               Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, France
      datePublished:2019-10-01
      dateModified:2025-06-30
      publisher:
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         name:Frontiers
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            volumeNumber:13
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               name:Frontiers in Cellular Neuroscience
      citation:
         https://doi.org/10.3389/fncel.2019.00438
      inLanguage:en
Person:
      name:Stefania Zappettini
      affiliation:
         Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, France
      name:Emilie Faivre
      affiliation:
         Inserm, CHU Lille, LabEx DISTALZ, UMR-S 1172 - JPArc, Université de Lille, France
      name:Antoine Ghestem
      affiliation:
         Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, France
      name:Sébastien Carrier
      affiliation:
         Inserm, CHU Lille, LabEx DISTALZ, UMR-S 1172 - JPArc, Université de Lille, France
      name:Luc Buée
      affiliation:
         Inserm, CHU Lille, LabEx DISTALZ, UMR-S 1172 - JPArc, Université de Lille, France
      name:David Blum
      affiliation:
         Inserm, CHU Lille, LabEx DISTALZ, UMR-S 1172 - JPArc, Université de Lille, France
      name:Monique Esclapez
      affiliation:
         Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, France
      name:Christophe Bernard
      affiliation:
         Aix Marseille Univ, INSERM, INS, Institut de Neurosciences des Systèmes, France
Organization:
      name:Frontiers
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      datePublished:2019
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         name:Frontiers in Cellular Neuroscience
Periodical:
      name:Frontiers in Cellular Neuroscience

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