PMC . NCBI . NLM . NIH . GOV {
}
We are analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC4554827/.
Title:
YAP and TAZ: a nexus for Hippo signaling and beyond - PMC
Description:
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
Title:
YAP and TAZ: a nexus for Hippo signaling and beyond - PMC
Description:
The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
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- Education
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š Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {š}
doi, pubmed, google, scholar, hippo, yap, cell, pmc, pathway, article, free, signaling, taz, yaptaz, lats, protein, kinase, cells, nuclear, biol, activity, stem, regulation, dev, transcription, complex, transcriptional, cancer, activation, nat, wnt, kinases, module, phosphorylation, figure, regulates, genes, cellular, growth, family, regulate, drosophila, jdevcel, proliferation, mst, target, role, components, cytoplasmic, gene,
Topics {āļø}
Ī²1-integrin/yap/taz signaling axis membrane-anchored metalloproteinase mt1-mmp swi/snf chromatin-remodeling complex stimulate cdc73āĪ²-catenin binding wnt/Ī²-catenin signaling regulates g-protein-coupled receptor signaling salvador/warts/hippo signaling network taz/tead/bmp signaling axis pmc beta search tumour-suppressor genes nf2/merlin yap/tazātead include bmp4 tubulin cytoskeleton-interacting effector tgf-Ī²āsmad pathway mt1-mmp-dependent control ubiquitylation-induced conformational change nuclear Ī²-catenin downregulation increased nuclear Ī²-catenin increased c-myc expression chromatin-remodeling/methyltransferase complexes [75ā78] ferm-domain protein expanded sik [salt-inducible kinases jakāstat pathway ligand serum-derived sphingosine-1-phosphate yap-dependent gene transcription cell-type-specific manner wnt/Ī²-catenin signalling Ī²-catenin destruction complex camp/pka signalling reinforces salvadorāwartsāhippo pathway inhibits taz-driven transformation dissociating phosphoinositide-dependent kinase-1 taz sequester Ī²-catenin nphp transition-zone complex tumor suppressor merlin/nf2 mammalian lats/ndr kinases yapātead4 combinatorially bind yapātea domain family plasma membrane-targeting warts homophilic cellācell contacts activate tead-mediated transcription ww domain-mediated interaction proteināprotein interaction network teadāyap complex suppresses Ī²-catenin remains phosphorylated crl4dcaf1-mediated ubiquitylation regulates lineage specification cell fate-controlling integrator apicalābasal polarity hypophosphorylated yap/taz translocate perkāeif2Ī±āatf4 axis
Questions {ā}
- Does the Hippo pathway regulate additional effectors besides YAP and TAZ?
- How can the Hippo pathway be therapeutically utilized in regeneration and cancer?
- How do YAP and TAZ differ and how are their nuclear/cytoplasmic functions regulated?
- How does the temporal and spatial organization and regulation of the Hippo pathway occur?
- How is LATS activated in different contexts?
- What underlies the context-dependent physiological roles and activities of YAP and TAZ?
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