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LIPIDWORLD . BIOMEDCENTRAL . COM {}

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  5. How Does Lipidworld.biomedcentral.com Make Money
  6. How Much Does Lipidworld.biomedcentral.com Make
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We are analyzing https://lipidworld.biomedcentral.com/articles/10.1186/s12944-024-02426-0.

Title:
Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment | Lipids in Health and Disease | Full Text
Description:
Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, and resistance to therapy. Pancreatic cancer (PC) is a highly aggressive malignancy of the gastrointestinal tract that has a dismal 5-year survival rate of less than 10%. Given the essential function of the pancreas in digestion, cancer progression severely disrupts its function. Standard treatments for PC such as surgical resection, chemotherapy, and radiotherapy. However, these therapies often face significant challenges, including biochemical recurrence and drug resistance. Given these limitations, new therapeutic approaches are being developed to target tumor metabolism. Dysregulation of cholesterol biosynthesis and alterations in fatty acids (FAs), such as palmitate, stearate, omega-3, and omega-6, have been observed in pancreatic cancer. These lipids serve as energy sources, signaling molecules, and essential components of cell membranes. Their accumulation fosters an immunosuppressive tumor microenvironment that supports cancer cell proliferation and metastasis. Moreover, lipid metabolism dysregulation within immune cells, particularly T cells, impairs immune surveillance and weakens the body’s defenses against cancer. Abnormal lipid metabolism also contributes to drug resistance in PC. Despite these challenges, targeting lipid metabolism may offer a promising therapeutic strategy. By enhancing lipid peroxidation, the induction of ferroptosis—a form of regulated cell death—could impair the survival of PC cells and hinder disease progression.
Website Age:
25 years and 10 months (reg. 1999-08-06).

Matching Content Categories {📚}

  • Health & Fitness
  • Science
  • Education

Content Management System {📝}

What CMS is lipidworld.biomedcentral.com built with?

Custom-built

No common CMS systems were detected on Lipidworld.biomedcentral.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of lipidworld.biomedcentral.com audience?

✈️ Decent Traffic: 20k - 50k visitors per month


Based on our best estimate, this website will receive around 21,119 visitors per month in the current month.

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How Does Lipidworld.biomedcentral.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (3)
yourbow.com, google.com, doceree.com

How Much Does Lipidworld.biomedcentral.com Make? {💰}


Display Ads {🎯}

$330 per month
Our calculations suggest that Lipidworld.biomedcentral.com earns between $219 and $603 monthly online from display advertisements.

Keywords {🔍}

cancer, pubmed, lipid, metabolism, article, google, scholar, cas, cells, cholesterol, cell, tumor, pancreatic, fatty, central, acid, progression, growth, role, metabolic, resistance, metastasis, therapeutic, drug, pathways, immune, synthesis, lipids, key, fasn, signaling, targeting, increased, acids, levels, expression, treatment, critical, survival, potential, res, dysregulation, accumulation, reprogramming, dysregulated, therapy, inflammation, proliferation, pathway, mol,

Topics {✒️}

nuclear factor kappa-light-chain-enhancer wnt5a-β-catenin-pparγ signaling pathway fzd5-mediated wnt/β-catenin pathway c-jun n-terminal kinase wnt/β-catenin signaling coalesce β-ketoacyl-acp synthase domain amp-activated protein kinase wnt/β-catenin pathway odd-chain fatty acid fatty acid β-oxidation pro-inflammatory cytokines il-1β springer nature long-chain fatty acids x-box-binding protein 1 myeloid-derived suppressor cells carnitine palmitoyl transferase-1a cd8 + t-cell number pro-metastatic nf-κb signaling fatty acid-binding proteins fatty-acid-binding proteins crispr/cas9 gene editing possess anti-tumoral properties multi-ligand membrane receptor cholesterol-rich lipid rafts weinheim baden-wurttemberg germany kank4/pi3k/akt axis additional information publisher targeting ppar-γ agonist author information authors cpt1a-mediated fat oxidation low-density lipoprotein receptor low-density lipoprotein/receptor low-density lipoprotein/receptor 3-hydroxy-3-methyl-glutaryl-coenzyme ferroptosis-mediated anticancer effects mettl14-mediated m6a modification lipid peroxidation-induced ferroptosis de novo synthesis decreased t-cell activity tumor necrosis factor-alpha reduced msc-induced chemoresistance exerting anti-tumor effects anti-inflammatory cytokine il-10 growth-suppressive effects induced tumor-stroma communication mediators early-stage pancreatic cancer sharing akt-mtorc1 signaling pathway stearoyl-coa desaturase induces cholesterol reprogramming-mediated activation

Schema {🗺️}

WebPage:
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         headline:Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment
         description:Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, and resistance to therapy. Pancreatic cancer (PC) is a highly aggressive malignancy of the gastrointestinal tract that has a dismal 5-year survival rate of less than 10%. Given the essential function of the pancreas in digestion, cancer progression severely disrupts its function. Standard treatments for PC such as surgical resection, chemotherapy, and radiotherapy. However, these therapies often face significant challenges, including biochemical recurrence and drug resistance. Given these limitations, new therapeutic approaches are being developed to target tumor metabolism. Dysregulation of cholesterol biosynthesis and alterations in fatty acids (FAs), such as palmitate, stearate, omega-3, and omega-6, have been observed in pancreatic cancer. These lipids serve as energy sources, signaling molecules, and essential components of cell membranes. Their accumulation fosters an immunosuppressive tumor microenvironment that supports cancer cell proliferation and metastasis. Moreover, lipid metabolism dysregulation within immune cells, particularly T cells, impairs immune surveillance and weakens the body’s defenses against cancer. Abnormal lipid metabolism also contributes to drug resistance in PC. Despite these challenges, targeting lipid metabolism may offer a promising therapeutic strategy. By enhancing lipid peroxidation, the induction of ferroptosis—a form of regulated cell death—could impair the survival of PC cells and hinder disease progression.
         datePublished:2025-01-13T00:00:00Z
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      headline:Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment
      description:Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, and resistance to therapy. Pancreatic cancer (PC) is a highly aggressive malignancy of the gastrointestinal tract that has a dismal 5-year survival rate of less than 10%. Given the essential function of the pancreas in digestion, cancer progression severely disrupts its function. Standard treatments for PC such as surgical resection, chemotherapy, and radiotherapy. However, these therapies often face significant challenges, including biochemical recurrence and drug resistance. Given these limitations, new therapeutic approaches are being developed to target tumor metabolism. Dysregulation of cholesterol biosynthesis and alterations in fatty acids (FAs), such as palmitate, stearate, omega-3, and omega-6, have been observed in pancreatic cancer. These lipids serve as energy sources, signaling molecules, and essential components of cell membranes. Their accumulation fosters an immunosuppressive tumor microenvironment that supports cancer cell proliferation and metastasis. Moreover, lipid metabolism dysregulation within immune cells, particularly T cells, impairs immune surveillance and weakens the body’s defenses against cancer. Abnormal lipid metabolism also contributes to drug resistance in PC. Despite these challenges, targeting lipid metabolism may offer a promising therapeutic strategy. By enhancing lipid peroxidation, the induction of ferroptosis—a form of regulated cell death—could impair the survival of PC cells and hinder disease progression.
      datePublished:2025-01-13T00:00:00Z
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         Tumor microenvironment
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         Ferroptosis
         Cancer therapy
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         Medical Biochemistry
         Clinical Nutrition
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                     name:Qinba State Key Laboratory of Biological Resources and Ecological Environment, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Bashan Mountains Bioresources Comprehensive Development C.I.C, Shaanxi University of Technology, Qinling, Hanzhong, China
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               type:PostalAddress
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               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Yanhui Yang
      affiliation:
            name:Henan University of Science and Technology
            address:
               name: Emergency surgery Dapartment (Trauma center), The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
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      name:Department of Epidemiology and Health Statistics, School of Public Health, Dalian Medical University, Dalian, China
      name:Qinba State Key Laboratory of Biological Resources and Ecological Environment, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Bashan Mountains Bioresources Comprehensive Development C.I.C, Shaanxi University of Technology, Qinling, Hanzhong, China
      name:Qinba State Key Laboratory of Biological Resources and Ecological Environment, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Bashan Mountains Bioresources Comprehensive Development C.I.C, Shaanxi University of Technology, Qinling, Hanzhong, China
      name:Interventional Therapy Department, The Second Affiliated Hospital of Dalian Medical University, Dalian, P.R. China
      name: Emergency surgery Dapartment (Trauma center), The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China

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