
NCBI . NLM . NIH . GOV {
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Title[redir]:
NAT10: An RNA cytidine transferase regulates fatty acid metabolism in cancer cells - PMC
Description:
Nâ4 cytidine acetylation (ac4C) is an epitranscriptomics modification catalyzed by Nâacetyltransferase 10 (NAT10); important for cellular mRNA stability, rRNA biogenesis, cell proliferation and epithelial to mesenchymal transition (EMT). However, ...
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Keywords {đ}
nat, cancer, cells, acid, cell, lipid, acc, figure, genes, metabolism, rna, fatty, doi, acsl, pubmed, google, scholar, metabolic, analysis, expression, data, pmc, knockdown, mcf, article, free, palmitate, showed, hela, performed, mrna, breast, levels, significant, acetylation, pathways, modification, study, accumulation, assay, sirna, impact, min, stability, enriched, survival, formation, pathway, based, identified,
Topics {âď¸}
gasâchromatographyâtandem mass spectroscopy tnfÎąâmediated proâinflammatory activities longâchain acylâcoa synthetases iceâcold phosphateâbuffered saline nat10âmediated ac4câmediated pathways nat10âdepleted palmitateâloaded cells proâinflammatory phenotypic shift longâchain fatty acids gcibâtofâsims imaging transâdodecâ3âenoic acid transâdodecâ2âenoic acid illumina hiseq/novaseq platform fatty acylâcoa formation quantitative crossâevolutionary mapping pmc beta search nkx2â8 deletionâinduced reprogramming highâthroughput rna sequencing fatty acid betaâoxidation mediating n4âacetylcytidine modification nat10âmediated ac4c modification er+/her2+ breast cancer palmitateâdriven cancer cells palmitateâdriven lipid accumulation nat10âmediated rna acetylation cgmpâpkg signalling pathway paâsinat10 versus paâsic acetylated rna immunoprecipitationâseq oligoâattached magnetic beads nat10âdependent ac4c modification nat10âmediated ac4c reduction nat10âdepleted cells loaded nat10âdeficient cancer cells pairedâend clean reads ac4câmediated mrna stability nat10âdepleted cancer cells palmitateâloaded cancer cells writingâoriginal draft preparation palmitateâloaded cells transfected performed proteinâprotein interaction fatty acylâcoa rna cytidine transferase performed western blot rnase free water conventional antiâcancer treatment acripâseq data generated fa free bsa intracellular free fas fatty acid oxidation ac4c mediated modification shortâchain fas
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