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Title[redir]:
Cholesterol and CDON Regulate Sonic Hedgehog Release from Pancreatic Cancer Cells - PMC
Description:
Background: Sonic Hedgehog (Shh) is a tightly regulated membrane-associated morphogen and a known driver of tumorigenesis in pancreatic ductal adenocarcinoma (PDAC). After processing, Shh remains at the plasma membrane of Shh producing cells, ...
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Keywords {๐}
shh, cells, cdon, pdac, release, cholesterol, pancreatic, cell, cancer, doi, pubmed, google, scholar, expression, hedgehog, human, fig, capan, pmc, pdec, article, mia, paca, signaling, relative, tumor, boi, bxpc, shrna, free, levels, control, protein, response, treatment, hbss, data, pathway, supplementary, released, sonic, study, statin, lines, disp, nlm, ductal, drosophila, results, model,
Topics {โ๏ธ}
phosphate buffered saline room temperature fluorescence-activated cell sorting lsl-krasg12d-lsl-trp53r172h-pdx1-cre mice messenger rna buffer saline solution modified eagle medium pancreatic ductal adenocarcinoma s6k target site rt-qpcr endogenous cdon mrna fniii domain anti-mouse igg-horseradish peroxidase fccc genomics facility cholesterol-modified hedgehog ligand rna interference cell adhesion molecule-related sonic hedgehog pathway rna 5โmin pbs-tween20 mrna shh-mediated stromal remodeling cholesterol-regulated hh-release pathway nontargeting shh precursor protein housekeeping geneโยฑโstandard error produce high-titer lentivirus sonic hedgehog endogenous cdon protein pmc beta search green pdac cell-lines bxpc-3 rabbit polyclonal anti-shh polyclonal rabbit anti-shh nt shrna rt authenticated pdac cells mouse anti-alpha-tubulin hedgehog signaling proteins pmc copyright notice rabbit polyclonal anti-cdon rabbit anti-beta-actin cholesterol-mediated shh release pancreatic cancer cells ripa buffer 2โรโloading buffer substrate solution stop solution human pancreatic carcinoma pbs
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