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Title:
Stromal Cells in the Tumor Microenvironment | SpringerLink
Description:
The tumor microenvironment comprises a mass of heterogeneous cell types, including immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly becoming clear that the development of this support niche is critical to the continued...
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Questions {❓}

How does the extracellular matrix direct gene expression?
Inflammation and cancer: back to Virchow?

Schema {🗺️}

ScholarlyArticle:
      headline:Stromal Cells in the Tumor Microenvironment
      pageEnd:114
      pageStart:99
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-78127-3.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Stromal Immunology
         isbn:
            978-3-319-78127-3
            978-3-319-78125-9
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Alice E. Denton
            affiliation:
                  name:Babraham Institute
                  address:
                     name:Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Edward W. Roberts
            affiliation:
                  name:University of California San Francisco
                  address:
                     name:Department of Pathology, University of California San Francisco, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Douglas T. Fearon
            affiliation:
                  name:Cold Spring Harbor Laboratory, Weill Cornell Medical College
                  address:
                     name:Cold Spring Harbor Laboratory, Weill Cornell Medical College, New York, USA
                     type:PostalAddress
                  type:Organization
            type:Person
      keywords:Cancer-associated fibroblast, Tumor microenvironment, Stromal immunology, Immunotherapy
      description:The tumor microenvironment comprises a mass of heterogeneous cell types, including immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly becoming clear that the development of this support niche is critical to the continued uncontrolled growth of the cancer. The tumor microenvironment contributes to the maintenance of cancer stemness and also directly promotes angiogenesis, invasion, metastasis, and chronic inflammation. In this chapter, we describe on the role of fibroblasts, specifically termed cancer-associated fibroblasts (CAFs), in the promotion and maintenance of cancers. CAFs have a multitude of effects on the growth and maintenance of cancer, and here we focus on their roles in modulating immune cells and responses; CAFs both inhibit immune cell access to the tumor microenvironment and inhibit their functions within the tumor. Finally, we describe the potential modulation of CAF function as an adjunct to bolster the effectiveness of cancer immunotherapies.
      datePublished:2018
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Book:
      name:Stromal Immunology
      isbn:
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         978-3-319-78125-9
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      name:Springer International Publishing
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      name:Babraham Institute
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      address:
         name:Department of Pathology, University of California San Francisco, San Francisco, USA
         type:PostalAddress
      name:Cold Spring Harbor Laboratory, Weill Cornell Medical College
      address:
         name:Cold Spring Harbor Laboratory, Weill Cornell Medical College, New York, USA
         type:PostalAddress
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            address:
               name:Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Edward W. Roberts
      affiliation:
            name:University of California San Francisco
            address:
               name:Department of Pathology, University of California San Francisco, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Douglas T. Fearon
      affiliation:
            name:Cold Spring Harbor Laboratory, Weill Cornell Medical College
            address:
               name:Cold Spring Harbor Laboratory, Weill Cornell Medical College, New York, USA
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK
      name:Department of Pathology, University of California San Francisco, San Francisco, USA
      name:Cold Spring Harbor Laboratory, Weill Cornell Medical College, New York, USA
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