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Title:
Serotonin Modulation of Macrophage Polarization: Inflammation and Beyond | SpringerLink
Description:
Macrophages display a ample plethora of effector functions whose acquisition is promoted by the surrounding cytokine and cellular environment. Depending on the stimulus, macrophages become specialized (“polarized”) for either pathogen elimination, tissue...
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Keywords {🔍}

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Topics {✒️}

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Questions {❓}

5-HT2B Receptor on Macrophages: What for?
Functional consequence of serotonin/5-HT2B receptor signaling in heart: role of mitochondria in transition between hypertrophy and heart failure?
Serotonin: a double-edged sword for the liver?

Schema {🗺️}

ScholarlyArticle:
      headline:Serotonin Modulation of Macrophage Polarization: Inflammation and Beyond
      pageEnd:115
      pageStart:89
      image:https://media.springernature.com/w153/springer-static/cover/book/978-3-319-07320-0.jpg
      genre:
         Biomedical and Life Sciences
         Biomedical and Life Sciences (R0)
      isPartOf:
         name:Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
         isbn:
            978-3-319-07320-0
            978-3-319-07319-4
         type:Book
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Mateo de las Casas-Engel
            affiliation:
                  name:Consejo Superior de Investigaciones Científicas (CSIC)
                  address:
                     name:Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Angel L. Corbí
            affiliation:
                  name:Consejo Superior de Investigaciones Científicas (CSIC)
                  address:
                     name:Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      keywords:Inflammation, Macrophages, Psychiatric diseases, Serotonin, Serotonin receptor
      description:Macrophages display a ample plethora of effector functions whose acquisition is promoted by the surrounding cytokine and cellular environment. Depending on the stimulus, macrophages become specialized (“polarized”) for either pathogen elimination, tissue repair and wound healing or immunosuppression. This “polarization” versatility allows macrophages to critically contribute to tissue homeostasis, as they promote initiation and resolution of inflammatory responses. As a consequence, deregulation of the tissue macrophage polarization balance is an etiological agent of chronic inflammation, autoimmune diseases, cancer and even obesity and insulin resistance. In the present review we describe current concepts on the molecular basis and the patho-physiological implications of macrophage polarization, and describe its modulation by serotonin (5-HT), a neurotransmitter that regulates inflammation and tissue repair via a large set of receptors (5-HTR1-7). 5-HT modulates the phenotypic and functional polarization of macrophages, and contributes to the maintenance of an anti-inflammatory state mainly via 5-HTR2B and 5-HTR7, whose activation has a great impact on macrophage gene expression profile. The identification of 5-HTR2B and 5-HTR7 as functionally-relevant polarization markers suggests their therapeutic value in inflammatory pathologies as well as their potential involvement in linking the immune and nervous systems.
      datePublished:2014
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Book:
      name:Oxidative Stress and Inflammation in Non-communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
      isbn:
         978-3-319-07320-0
         978-3-319-07319-4
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      name:Springer International Publishing
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         name:Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
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      name:Consejo Superior de Investigaciones Científicas (CSIC)
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         name:Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
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            address:
               name:Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
               type:PostalAddress
            type:Organization
      name:Angel L. Corbí
      affiliation:
            name:Consejo Superior de Investigaciones Científicas (CSIC)
            address:
               name:Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain
               type:PostalAddress
            type:Organization
      email:[email protected]
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