LINK . SPRINGER . COM {}

Matching Content Categories {📚}

• Science
• Education
• Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

cells, nanog, oct, cell, stat, lon, expression, hcc, figure, pstat, stem, cancer, snail, emt, tumor, article, pubmed, metastasis, assay, activation, lctrol, invasion, google, scholar, protein, cas, coexpression, transition, signaling, significantly, overexpression, epithelialmesenchymal, genes, octnanog, results, vivo, cat, carcinoma, proliferation, pathway, found, showed, nucleus, control, knockdown, analysis, gene, transcription, hepatocellular, properties,

Topics {✒️}

wei-zhong wu & zheng-gang ren alexa fluor®488-labeled anti-nanog alexa fluor®568-labeled anti-nanog anti-phospho-stat3 try705 antibody underwent epithelial-mesenchymal transition promote epithelial-mesenchymal transition inducing epithelial-mesenchymal transition epithelial-mesenchymal transition change promotes epithelial-mesenchymal transition zinc-finger transcription factors epithelial-mesenchymal transition phenotype jak-stat3-snail signaling pathway impacts cell differentiation oct4/nanog-mediated stat3 activation putative stat3-binding sites dmem-f12 medium supplemented oct4 regulates p-stat3 zheng-gang ren epithelial-mesenchymal transition epithelial mesenchymal transition oct4/nanog-induced snail expression ankyrin-regulated multidrug efflux anti-p-stat3-y705 antibody quantitative real-time pcr real-time rt-pcr anti-nanog-mediated immunoprecipitates article download pdf cloning vector pgmlv-sc1 oct4/nanog modulates activation ultra-low-attachment plate lentiviral vector pgmlv-pa6 epithelial gene e-cadherin anti-nanog monoclonal antibody represses e-cadherin transcription oct4/nanog-promoted snail expression specific pathogen-free conditions stat3-specific transcriptional activation shrna-mediated stat3 knockdown protein a-sepharose beads open access license oct4/nanog-mediated emt 20 ng/ml human bfgf immunoprecipitate dna-protein complexes sphere-forming ability assay embryonic stem cell stat3-dependent snail activation emt-phenotypic cancer cells oct4/nanog/stat3 signaling oct4/nanog-induced emt attenuates invasion/metastatic ability

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling
         description:Oct4 and Nanog are key regulatory genes that maintain the pluripotency and self-renewal properties of embryonic stem cells. We previously reported that the two stemness markers were tightly associated with cancer progression and poor outcomes of hepatocellular carcinoma. In this study, we demonstrate that coexpression of Oct4/Nanog modulates activation of signal transducer and activator of transcription 3 (Stat3), an oncogenic transcription factor that is activated in many human malignancies including hepatocellular carcinoma (HCC), as well as the expression of Snail, a key regulator implicated in epithelial-mesenchymal transition and tumor metastasis. Oct4 and Nanog were ectopic expressed in MHCC97-L cell lines via lentiviral gene transfection. The stemness characteristics including self-renewal, proliferation, chemoresistance, and tumorigenicity were assessed. The effect of coexpression of Oct4 and Nanog on epithelial-mesenchymal transition change, and the underlying molecular signaling was investigated. Ectopic coexpression of Oct4 and Nanog empowered MHCC97-L cells with cancer stem cell (CSC) properties, including self-renewal, extensive proliferation, drug resistance, and high tumorigenic capacity. Significantly, Oct4 and Nanog encouraged epithelial-mesenchymal transition change contributing to tumor migration, invasion/metastasis in vitro and in vivo. Following molecular mechanism investigation indicated Oct4/Nanog-regulated epithelial-mesenchymal transition change through Stat3-dependent Snail activation. Moreover, silencing Stat3 abrogates Oct4/Nanog-mediated epithelial-mesenchymal transition (EMT) change and invasion/metastasis in HCC. We delineate Oct4 and Nanog initiate stem cell characteristics in hepatocellular carcinoma and promote epithelial-mesenchymal transition through activation of Stat3/Snail signaling. Our findings propose Stat3/Snail pathway as a novel therapeutic target for the treatment of progression and metastasis of HCC with CSC-like signatures and epithelial-mesenchymal transition phenotype.
         datePublished:2015-03-11T00:00:00Z
         dateModified:2015-03-11T00:00:00Z
         pageStart:1
         pageEnd:13
         license:https://creativecommons.org/publicdomain/zero/1.0/
         sameAs:https://doi.org/10.1186/s13045-015-0119-3
         keywords:
            Hepatocellular carcinoma
            Oct4
            Nanog
            Stat3
            Epithelial-mesenchymal transition
            Oncology
            Hematology
            Cancer Research
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig6_HTML.gif
         isPartOf:
            name:Journal of Hematology & Oncology
            issn:
               1756-8722
            volumeNumber:8
            type:
               Periodical
               PublicationVolume
         publisher:
            name:BioMed Central
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Xin Yin
               affiliation:
                     name:Fudan University
                     address:
                        name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bo-Heng Zhang
               affiliation:
                     name:Fudan University
                     address:
                        name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Su-Su Zheng
               affiliation:
                     name:Fudan University
                     address:
                        name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dong-Mei Gao
               affiliation:
                     name:Fudan University
                     address:
                        name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Shuang-Jian Qiu
               affiliation:
                     name:Fudan University
                     address:
                        name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Wei-Zhong Wu
               affiliation:
                     name:Fudan University
                     address:
                        name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zheng-Gang Ren
               affiliation:
                     name:Fudan University
                     address:
                        name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling
      description:Oct4 and Nanog are key regulatory genes that maintain the pluripotency and self-renewal properties of embryonic stem cells. We previously reported that the two stemness markers were tightly associated with cancer progression and poor outcomes of hepatocellular carcinoma. In this study, we demonstrate that coexpression of Oct4/Nanog modulates activation of signal transducer and activator of transcription 3 (Stat3), an oncogenic transcription factor that is activated in many human malignancies including hepatocellular carcinoma (HCC), as well as the expression of Snail, a key regulator implicated in epithelial-mesenchymal transition and tumor metastasis. Oct4 and Nanog were ectopic expressed in MHCC97-L cell lines via lentiviral gene transfection. The stemness characteristics including self-renewal, proliferation, chemoresistance, and tumorigenicity were assessed. The effect of coexpression of Oct4 and Nanog on epithelial-mesenchymal transition change, and the underlying molecular signaling was investigated. Ectopic coexpression of Oct4 and Nanog empowered MHCC97-L cells with cancer stem cell (CSC) properties, including self-renewal, extensive proliferation, drug resistance, and high tumorigenic capacity. Significantly, Oct4 and Nanog encouraged epithelial-mesenchymal transition change contributing to tumor migration, invasion/metastasis in vitro and in vivo. Following molecular mechanism investigation indicated Oct4/Nanog-regulated epithelial-mesenchymal transition change through Stat3-dependent Snail activation. Moreover, silencing Stat3 abrogates Oct4/Nanog-mediated epithelial-mesenchymal transition (EMT) change and invasion/metastasis in HCC. We delineate Oct4 and Nanog initiate stem cell characteristics in hepatocellular carcinoma and promote epithelial-mesenchymal transition through activation of Stat3/Snail signaling. Our findings propose Stat3/Snail pathway as a novel therapeutic target for the treatment of progression and metastasis of HCC with CSC-like signatures and epithelial-mesenchymal transition phenotype.
      datePublished:2015-03-11T00:00:00Z
      dateModified:2015-03-11T00:00:00Z
      pageStart:1
      pageEnd:13
      license:https://creativecommons.org/publicdomain/zero/1.0/
      sameAs:https://doi.org/10.1186/s13045-015-0119-3
      keywords:
         Hepatocellular carcinoma
         Oct4
         Nanog
         Stat3
         Epithelial-mesenchymal transition
         Oncology
         Hematology
         Cancer Research
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_Fig6_HTML.gif
      isPartOf:
         name:Journal of Hematology & Oncology
         issn:
            1756-8722
         volumeNumber:8
         type:
            Periodical
            PublicationVolume
      publisher:
         name:BioMed Central
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Xin Yin
            affiliation:
                  name:Fudan University
                  address:
                     name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bo-Heng Zhang
            affiliation:
                  name:Fudan University
                  address:
                     name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Su-Su Zheng
            affiliation:
                  name:Fudan University
                  address:
                     name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dong-Mei Gao
            affiliation:
                  name:Fudan University
                  address:
                     name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Shuang-Jian Qiu
            affiliation:
                  name:Fudan University
                  address:
                     name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Wei-Zhong Wu
            affiliation:
                  name:Fudan University
                  address:
                     name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zheng-Gang Ren
            affiliation:
                  name:Fudan University
                  address:
                     name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Hematology & Oncology
      issn:
         1756-8722
      volumeNumber:8
Organization:
      name:BioMed Central
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Fudan University
      address:
         name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
         type:PostalAddress
      name:Fudan University
      address:
         name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Xin Yin
      affiliation:
            name:Fudan University
            address:
               name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Bo-Heng Zhang
      affiliation:
            name:Fudan University
            address:
               name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Su-Su Zheng
      affiliation:
            name:Fudan University
            address:
               name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Dong-Mei Gao
      affiliation:
            name:Fudan University
            address:
               name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Shuang-Jian Qiu
      affiliation:
            name:Fudan University
            address:
               name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Wei-Zhong Wu
      affiliation:
            name:Fudan University
            address:
               name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
      name:Zheng-Gang Ren
      affiliation:
            name:Fudan University
            address:
               name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
      name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
      name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
      name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
      name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
      name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China
      name:Liver Cancer Institute, Zhong Shan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China

External Links {🔗}(122)

• Explore the financials of https://www.springernature.com/gp/authors
• How much income is https://link.springernature.com/home/ earning monthly?
• How much profit does https://order.springer.com/public/cart generate?
• https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research income
• How much revenue does https://jhoonline.biomedcentral.com/about generate?
• Monthly income for https://submission.nature.com/new-submission/13045/3
• How much does https://doi.org/10.1097%2F00000658-200007000-00003 bring in each month?
• How much revenue does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421103 generate?
• Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10862190 earns monthly
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=Risk%20factors%2C%20prevention%2C%20and%20management%20of%20postoperative%20recurrence%20after%20resection%20of%20hepatocellular%20carcinoma&journal=Ann%20Surg&doi=10.1097%2F00000658-200007000-00003&volume=232&pages=10-24&publication_year=2000&author=Tung-Ping%20Poon%2CR&author=Fan%2CST&author=Wong%2CJ?
• What is the monthly revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779499?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17062128's total income per month
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=CD44%2B%2FCD24-%20breast%20cancer%20cells%20exhibit%20enhanced%20invasive%20properties%3A%20an%20early%20step%20necessary%20for%20metastasis&journal=Breast%20Cancer%20Res&doi=10.1186%2Fbcr1610&volume=8&publication_year=2006&author=Sheridan%2CC&author=Kishimoto%2CH&author=Fuchs%2CRK&author=Mehrotra%2CS&author=Bhat-Nakshatri%2CP&author=Turner%2CCH have monthly?
• How much income is https://doi.org/10.1073%2Fpnas.0530291100 earning monthly?
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC153034 generate monthly?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12629218's total income per month
• How much does http://scholar.google.com/scholar_lookup?&title=Prospective%20identification%20of%20tumorigenic%20breast%20cancer%20cells&journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&doi=10.1073%2Fpnas.0530291100&volume=100&pages=3983-4&publication_year=2003&author=Al-Hajj%2CM&author=Wicha%2CMS&author=Benito-Hernandez%2CA&author=Morrison%2CSJ&author=Clarke%2CMF pull in monthly?
• Income figures for https://doi.org/10.1038%2Fnm0797-730
• How much cash flow does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9212098 have monthly?
• Find out how much http://scholar.google.com/scholar_lookup?&title=Human%20acute%20myeloid%20leukemia%20is%20organized%20as%20a%20hierarchy%20that%20originates%20from%20a%20primitive%20hematopoietic%20cell&journal=Nat%20Med&doi=10.1038%2Fnm0797-730&volume=3&pages=730-7&publication_year=1997&author=Bonnet%2CD&author=Dick%2CJE earns monthly
• Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14522905
• Get to know http://scholar.google.com/scholar_lookup?&title=Identification%20of%20a%20cancer%20stem%20cell%20in%20human%20brain%20tumors&journal=Cancer%20Res&volume=63&pages=5821-8&publication_year=2003&author=Singh%2CSK&author=Clarke%2CID&author=Terasaki%2CM&author=Bonn%2CVE&author=Hawkins%2CC&author=Squire%2CJ's earnings
• How much revenue does https://doi.org/10.1002%2Fhep.22082 bring in?
• What's the financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18275073?
• How much profit does http://scholar.google.com/scholar_lookup?&title=Identification%20of%20local%20and%20circulating%20cancer%20stem%20cells%20in%20human%20liver%20cancer&journal=Hepatology&doi=10.1002%2Fhep.22082&volume=47&pages=919-28&publication_year=2008&author=Yang%2CZF&author=Ngai%2CP&author=Ho%2CDW&author=Yu%2CWC&author=Ng%2CMN&author=Lau%2CCK make?
• Income figures for https://doi.org/10.1016%2Fj.cell.2008.03.027
• What are the total earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728032?
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18485877 bring in each month?
• How much profit does http://scholar.google.com/scholar_lookup?&title=The%20epithelial-mesenchymal%20transition%20generates%20cells%20with%20properties%20of%20stem%20cells&journal=Cell&doi=10.1016%2Fj.cell.2008.03.027&volume=133&pages=704-15&publication_year=2008&author=Mani%2CSA&author=Guo%2CW&author=Liao%2CMJ&author=Eaton%2CEN&author=Ayyanan%2CA&author=Zhou%2CAY make?
• What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19242781?
• What's the financial outcome of http://scholar.google.com/scholar_lookup?&title=The%20epithelial-to-mesenchymal%20transition%20and%20cancer%20stem%20cells%3A%20a%20coalition%20against%20cancer%20therapies&journal=J%20Mammary%20Gland%20Biol%20Neoplasia&doi=10.1007%2Fs10911-009-9110-3&volume=14&pages=29-43&publication_year=2009&author=Hollier%2CBG&author=Evans%2CK&author=Mani%2CSA?
• How much income does https://doi.org/10.1016%2FS0092-8674%2800%2981769-9 have?
• Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9814708
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=Formation%20of%20pluripotent%20stem%20cells%20in%20the%20mammalian%20embryo%20depends%20on%20the%20POU%20transcription%20factor%20Oct4&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981769-9&volume=95&pages=379-91&publication_year=1998&author=Nichols%2CJ&author=Zevnik%2CB&author=Anastassiadis%2CK&author=Niwa%2CH&author=Klewe-Nebenius%2CD&author=Chambers%2CI
• What's the financial intake of https://doi.org/10.1016%2FS0092-8674%2803%2900392-1?
• What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12787505 each month?
• Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Functional%20expression%20cloning%20of%20Nanog%2C%20a%20pluripotency%20sustaining%20factor%20in%20embryonic%20stem%20cells&journal=Cell&doi=10.1016%2FS0092-8674%2803%2900392-1&volume=113&pages=643-55&publication_year=2003&author=Chambers%2CI&author=Colby%2CD&author=Robertson%2CM&author=Nichols%2CJ&author=Lee%2CS&author=Tweedie%2CS
• How much does https://doi.org/10.1038%2Fng.127 rake in every month?
• Financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912221
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18443585 bring in each month?
• How much does http://scholar.google.com/scholar_lookup?&title=An%20embryonic%20stem%20cell-like%20gene%20expression%20signature%20in%20poorly%20differentiated%20aggressive%20human%20tumors&journal=Nat%20Genet&doi=10.1038%2Fng.127&volume=40&pages=499-507&publication_year=2008&author=Ben-Porath%2CI&author=Thomson%2CMW&author=Carey%2CVJ&author=Ge%2CR&author=Bell%2CGW&author=Regev%2CA pull in?
• How much does https://doi.org/10.1038%2Fnri2152 net monthly?
• What is the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17703229?
• Check the income stats for http://scholar.google.com/scholar_lookup?&title=Calcium%20signalling%20in%20lymphocyte%20activation%20and%20disease&journal=Nat%20Rev%20Immunol&doi=10.1038%2Fnri2152&volume=7&pages=690-702&publication_year=2007&author=Feske%2CS
• Discover the revenue of https://doi.org/10.1245%2Fs10434-012-2314-6
• Explore the financials of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22461131
• Earnings of http://scholar.google.com/scholar_lookup?&title=Coexpression%20of%20stemness%20factors%20Oct4%20and%20Nanog%20predict%20liver%20resection&journal=Ann%20Surg%20Oncol&doi=10.1245%2Fs10434-012-2314-6&volume=19&pages=2877-87&publication_year=2012&author=Yin%2CX&author=Li%2CYW&author=Zhang%2CBH&author=Ren%2CZG&author=Qiu%2CSJ&author=Yi%2CY
• How much does https://doi.org/10.1002%2Fjcb.21509 net monthly?
• What's the income generated by http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17914743 each month?
• Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Cancer%20metastasis%20facilitated%20by%20developmental%20pathways%3A%20sonic%20hedgehog%2C%20notch%2C%20and%20bone%20morphogenic%20proteins&journal=J%20Cell%20Biochem&doi=10.1002%2Fjcb.21509&volume=102&pages=829-39&publication_year=2007&author=Bailey%2CJM&author=Singh%2CPK&author=Hollingsworth%2CMA
• What are the total earnings of https://doi.org/10.1634%2Fstemcells.2007-0401?
• How much income is http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2818886 earning monthly?
• What are the total earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17932422?
• Financial intake of http://scholar.google.com/scholar_lookup?&title=Oct-4%20is%20critical%20for%20survival%2Fantiapoptosis%20of%20murine%20embryonic%20stem%20cells%20subjected%20to%20stress%3A%20effects%20associated%20with%20Stat3%2Fsurvivin&journal=Stem%20Cells&doi=10.1634%2Fstemcells.2007-0401&volume=26&pages=30-4&publication_year=2008&author=Guo%2CY&author=Mantel%2CC&author=Hromas%2CRA&author=Broxmeyer%2CHE
• What is the monthly revenue of https://doi.org/10.1074%2Fjbc.M800109200?
• How much does http://scholar.google.com/scholar_lookup?&title=Hyaluronan-CD44%20interaction%20activates%20stem%20cell%20marker%20Nanog%2C%20Stat-3-mediated%20MDR1%20gene%20expression%2C%20and%20ankyrin-regulated%20multidrug%20efflux%20in%20breast%20and%20ovarian%20tumor%20cells&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M800109200&volume=283&pages=17635-51&publication_year=2008&author=Brguignon%2CLY&author=Peyrollier%2CK&author=Xia%2CW&author=Gilad%2CE pull in monthly?
• Learn about the earnings of https://doi.org/10.1158%2F1541-7786.MCR-11-0271
• See how much http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243808 makes per month
• How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21976712 generate monthly?
• http://scholar.google.com/scholar_lookup?&title=IL-6%20promotes%20head%20and%20neck%20tumor%20metastasis%20by%20inducing%20epithelial-mesenchymal%20transition%20via%20the%20JAK-STAT3-SNAIL%20signaling%20pathway&journal=Mol%20Cancer%20Res&doi=10.1158%2F1541-7786.MCR-11-0271&volume=9&pages=1658-67&publication_year=2011&author=Yadav%2CA&author=Kumar%2CB&author=Datta%2CJ&author=Teknos%2CTN&author=Kumar%2CP's total income per month
• Discover the revenue of https://doi.org/10.1021%2Fcb7001973
• Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18154266
• Get to know http://scholar.google.com/scholar_lookup?&title=An%20oxazole-based%20small-molecule%20Stat3%20inhibitor%20modulates%20Stat3%20stability%20and%20processing%20and%20induces%20antitumor%20cell%20effects&journal=ACS%20Chem%20Biol&doi=10.1021%2Fcb7001973&volume=2&pages=787-98&publication_year=2007&author=Siddiquee%2CKA&author=Gunning%2CPT&author=Glenn%2CM&author=Katt%2CWP&author=Zhang%2CS&author=Schrock%2CC's earnings
• How much does https://doi.org/10.1016%2FS1535-6108%2803%2900270-8 pull in monthly?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14667503's revenue stream
• What's the income of http://scholar.google.com/scholar_lookup?&title=Oct-3%2F4%20is%20a%20dosedependent%20oncogenic%20fate%20determinant&journal=Cancer%20Cell&doi=10.1016%2FS1535-6108%2803%2900270-8&volume=4&pages=361-70&publication_year=2003&author=Gidekel%2CS&author=Pizov%2CG&author=Bergman%2CY&author=Pikarsky%2CE?
• What's the financial intake of https://doi.org/10.1038%2Fsj.bjc.6600017?
• How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746537 net monthly?
• Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11857019's earnings
• How much money does http://scholar.google.com/scholar_lookup?&title=Inverse%20correlation%20between%20E-cadherin%20and%20Snail%20expression%20in%20hepatocellular%20carcinoma%20cell%20lines%20in%20vitro%20and%20in%20vivo&journal=Br%20J%20Cancer&doi=10.1038%2Fsj.bjc.6600017&volume=86&pages=98-101&publication_year=2002&author=Jiao%2CW&author=Miyazaki%2CK&author=Kitajima%2CY make?
• What's the total monthly financial gain of https://doi.org/10.1038%2Fnrm757?
• See how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11994736 makes per month
• What's http://scholar.google.com/scholar_lookup?&title=The%20snail%20superfamily%20of%20zinc-finger%20transcription%20factors&journal=Nat%20Rev%20Mol%20Cell%20Biol&doi=10.1038%2Fnrm757&volume=3&pages=155-66&publication_year=2002&author=Nieto%2CMA's gross income?
• What are the total earnings of https://doi.org/10.1016%2Fj.canlet.2014.06.023?
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25153349's total income per month
• What's http://scholar.google.com/scholar_lookup?&title=N-myc%20downstream-regulated%20gene%202%28NDRG2%29%20suppresses%20the%20epithelial%20mesenchymal%20transition%20%28EMT%29%20in%20breast%20cancer%20cells%20via%20STAT3%2FSnail%20signaling&journal=Cancer%20Lett&doi=10.1016%2Fj.canlet.2014.06.023&volume=354&pages=33-42&publication_year=2014&author=Kim%2CMJ&author=Lim%2CJ&author=Yang%2CY&author=Lee%2CMS&author=Lim%2CJS's gross income?
• What's the monthly income of https://doi.org/10.1136%2Fjcp.2006.036970?
• How much does http://scholar.google.com/scholar_lookup?&title=Altered%20p-STAT3%20%28tyr705%29%20expression%20is%20associated%20with%20histological%20grading%20and%20intratumour%20microvessel%20density%20in%20hepatocellular%20carcinoma&journal=Clin%20Pathol&doi=10.1136%2Fjcp.2006.036970&volume=60&pages=642-8&publication_year=2007&author=Yang%2CSF&author=Wang%2CSN&author=Wu%2CCF&author=Yeh%2CYT&author=Chai%2CCY&author=Chunag%2CSC earn?
• Check the income stats for https://doi.org/10.3350%2Fkjhep.2011.17.1.12
• Get to know what's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304621
• Explore the financials of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21494073
• Earnings of http://scholar.google.com/scholar_lookup?&title=Clinicopathologic%20significance%20of%20the%20expression%20of%20Snail%20in%20hepatocellular%20carcinoma&journal=Korean%20J%20Hepatol&doi=10.3350%2Fkjhep.2011.17.1.12&volume=17&pages=12-8&publication_year=2011&author=Woo%2CHY&author=Min%2CAL&author=Choi%2CJY&author=Bae%2CSH&author=Yoon%2CSK&author=Jung%2CCK
• Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15146329 earns monthly
• How much does http://scholar.google.com/scholar_lookup?&title=Stepwise%20metastatic%20human%20hepatocellular%20carcinoma%20cell%20model%20system%20with%20multiple%20metastatic%20potentials%20established%20through%20consecutive%20in%20vivo%20selection%20and%20studies%20on%20metastatic%20characteristics&journal=J%20Cancer%20Res%20Clin%20Oncol&doi=10.1007%2Fs00432-004-0564-9&volume=130&pages=460-8&publication_year=2004&author=Li%2CY&author=Tian%2CB&author=Yang%2CJ&author=Zhao%2CL&author=Wu%2CX&author=Ye%2CSL rake in every month?
• Income figures for https://doi.org/10.1158%2F1078-0432.CCR-09-2904
• What's the profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20570927?
• How much does http://scholar.google.com/scholar_lookup?&title=Depletion%20of%20tumor-associated%20macrophages%20enhances%20the%20effect%20of%20sorafenib%20in%20metastatic%20liver%20cancer%20models%20by%20antimetastatic%20and%20antiangiogenic%20effects&journal=Clin%20Cancer%20Res&doi=10.1158%2F1078-0432.CCR-09-2904&volume=16&pages=3420-30&publication_year=2010&author=Zhang%2CW&author=Zhu%2CXD&author=Sun%2CHC&author=Xiong%2CYQ&author=Zhuang%2CPY&author=Xu%2CHX rake in every month?
• Explore the financials of https://citation-needed.springer.com/v2/references/10.1186/s13045-015-0119-3?format=refman&flavour=references
• Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Xin%20Yin
• How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Xin%20Yin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Bo-Heng%20Zhang pull in monthly?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Bo-Heng%20Zhang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Su-Su%20Zheng generate?
• What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Su-Su%20Zheng%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Dong-Mei%20Gao's revenue stream
• Financial intake of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Dong-Mei%20Gao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• How much income does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Shuang-Jian%20Qiu have?
• What's the profit of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Shuang-Jian%20Qiu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Wei-Zhong%20Wu pull in monthly?
• Revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Wei-Zhong%20Wu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• Check the income stats for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Zheng-Gang%20Ren
• What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Zheng-Gang%20Ren%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• See how much https://static-content.springer.com/esm/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_MOESM1_ESM.tiff makes per month
• How much profit is https://static-content.springer.com/esm/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_MOESM2_ESM.tiff making per month?
• How much does https://static-content.springer.com/esm/art%3A10.1186%2Fs13045-015-0119-3/MediaObjects/13045_2015_119_MOESM3_ESM.doc earn?
• Profit of https://crossmark.crossref.org/dialog/?doi=10.1186/s13045-015-0119-3
• Get to know what's the income of https://citation-needed.springer.com/v2/references/10.1186/s13045-015-0119-3?format=refman&flavour=citation
• How much does https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral earn?
• What's the profit of https://www.springernature.com/gp/products?
• Monthly income for https://www.springernature.com/gp/librarians
• How much does https://www.springernature.com/gp/societies bring in each month?
• Monthly income for https://www.springernature.com/gp/partners
• https://www.springer.com/'s financial summary
• Discover the revenue of https://www.nature.com/
• How much money does https://www.biomedcentral.com/ make?
• Learn about the earnings of https://www.palgrave.com/
• What's the revenue for https://www.apress.com/?
• How much does https://www.springernature.com/gp/legal/ccpa gross monthly?
• How much profit is https://www.springernature.com/gp/info/accessibility making per month?
• Learn about the earnings of https://support.springernature.com/en/support/home
• What's the total monthly financial gain of https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations?
• How much revenue does https://www.springernature.com/ produce monthly?

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Clipboard.js
• Prism.js

CDN Services {📦}

• Crossref