We are analyzing https://link.springer.com/article/10.1186/s12943-018-0847-4.

Title:
Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword | Molecular Cancer
Description:
N6-methyladenosine (m6A), the most prevalent modification of mammalian RNA, has received increasing attention. Although m6A has been shown to be associated with biological activities, such as spermatogenesis modulation, cell spermatogenesis and pluripotency, Drosophila sex determination, and the control of T cell homeostasis and response to heat shock, little is known about its roles in cancer biology and cancer stem cells. Recent articles have noted that some genes have abnormal m6A expression after tumorigenesis, including genes ABS2, RARA, MYB, MYC, ADAM19 and FOX1. Abnormal changes in the m6A levels of these genes are closely related to tumour occurrence and development. In this review, we summarized the ‘dual edge weapon’ role of RNA methylation in the tumorigenesis. We discussed RNA methylation could lead to not only tumour progression but also tumour suppression. Moreover, we clarified that the abnormal changes in the m6A enrichment of specific loci contribute to tumour occurrence and development, thereby representing a novel anti-cancer strategy by restoration to balanced RNA methylation in tumour cells.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, rna, modification, cell, mettl, levels, mrna, methylation, central, tumour, modifications, protein, cells, expression, aberrant, tumorigenesis, wang, nmethyladenosine, stem, development, role, ultimately, methyltransferase, lung, fto, suppressor, breast, translation, leads, gene, carcinoma, socs, high, glioblastoma, molecular, genes, aml, zhang, chen, nature, occurrence, proteins, important, decreased, hcc,

Topics {✒️}

s-adenosyl methionine-binding protein sex-determining gene sex-lethal post-transcriptional chemical modifications article download pdf zinc finger ccch-type methyl-substituted nucleoside constituents n6-methyladenosine rna methylation n6-methyladenosine-dependent regulation conserved m6a-binding pocket a-dependent translation control dna methylation-based prognosis mir-33a suppresses proliferation downstream signal il-7/stat5 il-7/stat5/socs pathways full access tumour-specific mrna behaviour mettl3−/mettl14-mediated mrna mrna n6-adenosine methyltransferase regulated protein-rna interactome small-cell lung carcinoma drosophila sex determination modulates m6a deposition drosophila include inducer early-stage breast cancer methionine adenosyltransferase 2a mrna methylation controls m6a-based modifications occur inhibiting tumor suppressor decreased rna methylation scientific research program isolated mammalian rna mammalian rna demethylase double-edged sword privacy choices/manage cookies adomet-binding subunit promote tumour growth rna methyltransferase complex obvious physiological abnormality messenger rna stability abundant rna modifications rna methylation regulates acute myeloid leukaemia m6a rna methylation renbing jia small molecular inhibitor discussed rna methylation balanced rna methylation rna methylation triggers histone methyltransferases ezh2 sex determining region

Schema {🗺️}

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         headline:Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword
         description:N6-methyladenosine (m6A), the most prevalent modification of mammalian RNA, has received increasing attention. Although m6A has been shown to be associated with biological activities, such as spermatogenesis modulation, cell spermatogenesis and pluripotency, Drosophila sex determination, and the control of T cell homeostasis and response to heat shock, little is known about its roles in cancer biology and cancer stem cells. Recent articles have noted that some genes have abnormal m6A expression after tumorigenesis, including genes ABS2, RARA, MYB, MYC, ADAM19 and FOX1. Abnormal changes in the m6A levels of these genes are closely related to tumour occurrence and development. In this review, we summarized the ‘dual edge weapon’ role of RNA methylation in the tumorigenesis. We discussed RNA methylation could lead to not only tumour progression but also tumour suppression. Moreover, we clarified that the abnormal changes in the m6A enrichment of specific loci contribute to tumour occurrence and development, thereby representing a novel anti-cancer strategy by restoration to balanced RNA methylation in tumour cells.
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      headline:Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword
      description:N6-methyladenosine (m6A), the most prevalent modification of mammalian RNA, has received increasing attention. Although m6A has been shown to be associated with biological activities, such as spermatogenesis modulation, cell spermatogenesis and pluripotency, Drosophila sex determination, and the control of T cell homeostasis and response to heat shock, little is known about its roles in cancer biology and cancer stem cells. Recent articles have noted that some genes have abnormal m6A expression after tumorigenesis, including genes ABS2, RARA, MYB, MYC, ADAM19 and FOX1. Abnormal changes in the m6A levels of these genes are closely related to tumour occurrence and development. In this review, we summarized the ‘dual edge weapon’ role of RNA methylation in the tumorigenesis. We discussed RNA methylation could lead to not only tumour progression but also tumour suppression. Moreover, we clarified that the abnormal changes in the m6A enrichment of specific loci contribute to tumour occurrence and development, thereby representing a novel anti-cancer strategy by restoration to balanced RNA methylation in tumour cells.
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      name:Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
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