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We are analyzing https://link.springer.com/article/10.1007/s13402-024-01011-y.

Title:
Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming | Cellular Oncology
Description:
Regulation of steroid hormone receptors (SHRs) on transcriptional reprogramming is crucial for breast cancer progression. SHRs, including estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) play key roles in remodeling the transcriptome of breast cancer cells. However, the molecular mechanisms by which SHRs regulate chromatin landscape in enhancer regions and transcription factor interactions remain largely unknown. In this review, we summarized the regulatory effects of 3 types of SHRs (AR, PR, and GR) on gene transcription through chromatin interactions and enhancer reprogramming. Specifically, AR and PR exhibit bi-directional regulatory effects (both inhibitory and promoting) on ER-mediated gene transcription, while GR modulates the transcription of pro-proliferation genes in ER-positive breast cancer cells. In addition, we have presented four enhancer reprogramming mechanisms (transcription factor cooperation, pioneer factor binding, dynamic assisted loading, and tethering) and the multiple enhancer-promoter contact models. Based on these mechanisms and models, this review proposes that the combination of multiple therapy strategies such as agonists/antagonists of SHRs plus endocrine therapy and the adoption of the latest sequencing technologies are expected to improve the efficacy of ER positive breast cancer treatment.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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  • Education
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Content Management System {๐Ÿ“}

What CMS is link.springer.com built with?

Custom-built

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Traffic Estimate {๐Ÿ“ˆ}

What is the average monthly size of link.springer.com audience?

๐ŸŒ  Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {๐Ÿ’ธ}

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Keywords {๐Ÿ”}

pubmed, article, google, scholar, cas, central, cancer, breast, receptor, cell, mol, transcription, glucocorticoid, estrogen, enhancer, biol, res, transcriptional, gene, chromatin, cells, nat, androgen, progesterone, sci, receptors, factor, binding, human, expression, reprogramming, activation, factors, nature, activity, eralpha, mechanisms, steroid, hormone, function, genome, foxa, action, protein, endocrinol, regulation, response, genet, commun, complex,

Topics {โœ’๏ธ}

enhancer-driven lineage-specific transcription illumina-based chip-exonuclease method ezh2-eralpha-greb1 transcriptional axis estrogen-receptor-positive breast cancer high-resolution data shows month download article/chapter articleย  google scholar hormone-induced breast cancer er-dependent gene expression her2-positive breast carcinomas lymphocyte-specific cellular enhancer estrogen receptor-dependent transcription er-positive breast cancer progestin-driven mammary cancer ligand-inducible growth state protein-nucleic acid complexes er-mediated gene transcription estrogen receptor-sp1 interactions oestrogen-dependent transcriptional activation retinoic acid receptor-alpha direct/indirect dna recruitment promote chromatin-based regulation oncogenic super-enhancer formation anti-diabetic drug response transcription factors access er-negative breast cancer full article pdf modulate oncogene-induced senescence endocrine-resistant breast cancer mutant estrogen receptors eralpha-regulated transcriptional program apolipoprotein-mediated cholesterol efflux pelp1-mediated stress signaling agonist-liganded glucocorticoid receptor triple-negative breast cancer cytokine-mediated endocrine resistance receptor-mediated transcriptional activation long-term clinical benefit foxa1/esr1 interacting pathway eralpha/sp1-mediated activation foxa1-dna binding properties direct cell-fate conversion related subjects cyclin d1/myc promoters myc/max/mad network promoting enhancer-promoter interaction 3d chromatin architecture fluorescence cross-correlation spectroscopy estrogen receptor cistrome estrogen receptor alpha

Questions {โ“}

  • Newton, Molecular mechanisms of glucocorticoid action: what is important?
  • Prekovic, Duality of glucocorticoid action in cancer: tumor-suppressor or oncogene?
  • Wysocka, Modification of enhancer chromatin: what, how, and why?

Schema {๐Ÿ—บ๏ธ}

WebPage:
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         headline:Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming
         description:Regulation of steroid hormone receptors (SHRs) on transcriptional reprogramming is crucial for breast cancer progression. SHRs, including estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) play key roles in remodeling the transcriptome of breast cancer cells. However, the molecular mechanisms by which SHRs regulate chromatin landscape in enhancer regions and transcription factor interactions remain largely unknown. In this review, we summarized the regulatory effects of 3 types of SHRs (AR, PR, and GR) on gene transcription through chromatin interactions and enhancer reprogramming. Specifically, AR and PR exhibit bi-directional regulatory effects (both inhibitory and promoting) on ER-mediated gene transcription, while GR modulates the transcription of pro-proliferation genes in ER-positive breast cancer cells. In addition, we have presented four enhancer reprogramming mechanisms (transcription factor cooperation, pioneer factor binding, dynamic assisted loading, and tethering) and the multiple enhancer-promoter contact models. Based on these mechanisms and models, this review proposes that the combination of multiple therapy strategies such as agonists/antagonists of SHRs plus endocrine therapy and the adoption of the latest sequencing technologies are expected to improve the efficacy of ER positive breast cancer treatment.
         datePublished:2024-11-14T00:00:00Z
         dateModified:2024-11-14T00:00:00Z
         pageStart:2073
         pageEnd:2090
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            Enhancer
            Breast cancer
            Estrogen receptor
            Steroid hormone receptors
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            general
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      headline:Regulatory mechanisms of steroid hormone receptors on gene transcription through chromatin interaction and enhancer reprogramming
      description:Regulation of steroid hormone receptors (SHRs) on transcriptional reprogramming is crucial for breast cancer progression. SHRs, including estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) play key roles in remodeling the transcriptome of breast cancer cells. However, the molecular mechanisms by which SHRs regulate chromatin landscape in enhancer regions and transcription factor interactions remain largely unknown. In this review, we summarized the regulatory effects of 3 types of SHRs (AR, PR, and GR) on gene transcription through chromatin interactions and enhancer reprogramming. Specifically, AR and PR exhibit bi-directional regulatory effects (both inhibitory and promoting) on ER-mediated gene transcription, while GR modulates the transcription of pro-proliferation genes in ER-positive breast cancer cells. In addition, we have presented four enhancer reprogramming mechanisms (transcription factor cooperation, pioneer factor binding, dynamic assisted loading, and tethering) and the multiple enhancer-promoter contact models. Based on these mechanisms and models, this review proposes that the combination of multiple therapy strategies such as agonists/antagonists of SHRs plus endocrine therapy and the adoption of the latest sequencing technologies are expected to improve the efficacy of ER positive breast cancer treatment.
      datePublished:2024-11-14T00:00:00Z
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         Breast cancer
         Estrogen receptor
         Steroid hormone receptors
         Enhancer reprogramming
         Cancer Research
         Biomedicine
         general
         Pathology
         Oncology
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               type:PostalAddress
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      name:Yan Chen
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            name:Huazhong Agricultural University
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               name:Gene Regulation and Diseases Lab, College of Life Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, PR China
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      name:Jing Yao
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            name:Huazhong University of Science and Technology
            address:
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            address:
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               type:PostalAddress
            type:Organization
            name:Hubei Key Laboratory of Precision Radiation Oncology
            address:
               name:Hubei Key Laboratory of Precision Radiation Oncology, Wuhan, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Li Li
      affiliation:
            name:Huazhong Agricultural University
            address:
               name:Gene Regulation and Diseases Lab, College of Life Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, PR China
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      name:Department of Critical Care Medicine, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
      name:Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China
      name:Gene Regulation and Diseases Lab, College of Life Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, PR China
      name:Gene Regulation and Diseases Lab, College of Life Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, PR China
      name:Cancer Center, Institute of Radiation Oncology, Hubei Key Laboratory of Precision Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Institute of Radiation Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
      name:Hubei Key Laboratory of Precision Radiation Oncology, Wuhan, China
      name:Gene Regulation and Diseases Lab, College of Life Science and Technology, College of Biomedicine and Health, Huazhong Agricultural University, Wuhan, PR China
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