We are analyzing https://link.springer.com/article/10.1007/s13402-024-01007-8.

Title:
Cell death in glioblastoma and the central nervous system | Cellular Oncology
Description:
Glioblastoma is the commonest and deadliest primary brain tumor. Glioblastoma is characterized by significant intra- and inter-tumoral heterogeneity, resistance to treatment and dismal prognoses despite decades of research in understanding its biological underpinnings. Encompassed within this heterogeneity and therapy resistance are severely dysregulated programmed cell death pathways. Glioblastomas recapitulate many neurodevelopmental and neural injury responses; in addition, glioblastoma cells are composed of multiple different transformed versions of CNS cell types. To obtain a greater understanding of the features underlying cell death regulation in glioblastoma, it is important to understand the control of cell death within the healthy CNS during homeostatic and neurodegenerative conditions. Herein, we review apoptotic control within neural stem cells, astrocytes, oligodendrocytes and neurons and compare them to glioblastoma apoptotic control. Specific focus is paid to the Inhibitor of Apoptosis proteins, which play key roles in neuroinflammation, CNS cell survival and gliomagenesis. This review will help in understanding glioblastoma as a transformed version of a heterogeneous organ composed of multiple varied cell types performing different functions and possessing different means of apoptotic control. Further, this review will help in developing more glioblastoma-specific treatment approaches and will better inform treatments looking at more direct brain delivery of therapeutic agents.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, google, scholar, article, cas, cell, death, cells, apoptosis, central, expression, gbm, levels, glioblastoma, brain, signaling, astrocytes, ciap, apoptotic, human, casp, xiap, survivin, protein, fas, neurons, survival, cancer, neuronal, pathway, trail, tumor, injury, activation, neurosci, factor, cns, significantly, res, high, resistance, oligodendrocyte, pea, inhibition, mol, cflip, stem, bcl, increases, glioma,

Topics {✒️}

akt1/gsk-3β/β-catenin-trim11/survivin pathway tumor-necrosis-factor-related apoptosis-inducing-ligand tumour-necrosis-factor-related apoptosis-inducing ligand gsk-3β/β-catenin signaling c-jun n-terminal kinase tnf-related apoptosis-inducing ligand generate gbm-specific pericytes pi3k-nf-κb-hif-1α-survivin pathway rabies virus glycoprotein-lactoferrin-liposomes granulocyte-colony stimulating factor tnf-jnk-axl-erk signaling axis wnt/β–catenin signaling pathway tropomyosin-related receptor kinase tumor necrosis factor-alpha tumor necrosis factor-α differentiated sh-sy5y cells brain-derived neurotrophic factor tnf-α-induced cell death glucocorticoid-induced tnfr-related death-inducing signaling complex nf-κb p65-ciap2 link kappa b-binding factor glioblastoma-derived stem cells neural stem/progenitor cells article download pdf neuron-specific anti-apoptotic protein nf-κb signaling mediates aav-mediated gene editing fas/fasl-induced cell death xiap-table 1-tak1 complex [467 dysregulated ras-mek-erk apoptosis-related gene expression transcription factor nf-κb stem cell-based approaches apoptotic protease-activating factor-1 g1 cyclin-dependent kinases heavy anti-apoptotic skewing interferon-β sensitizes glioblastoma interferon-gamma-induced death death-receptor mediated death tumor-infiltrating immune cells tumor necrosis factor erk/map kinase pathway bh3 mimetic–induced apoptosis toxin-induced neuronal damage cerebellar granule cells fas ligand-induced apoptosis smac mimetic-induced upregulation nf-kappab-dependent regulation ectromelia virus-induced apoptosis

Questions {❓}

, CD95 (Fas/Apo-1) as a receptor governing astrocyte apoptotic or inflammatory responses: a key role in brain inflammation?
Boulay, Notch signaling in glioblastoma: a developmental drug target?
Dhandapani, Astrocyte-specific expression of survivin after intracerebral hemorrhage in mice: a possible role in reactive gliosis?
Maellaro, Calpains and cancer: friends or enemies?

Schema {🗺️}

WebPage:
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         headline:Cell death in glioblastoma and the central nervous system
         description:Glioblastoma is the commonest and deadliest primary brain tumor. Glioblastoma is characterized by significant intra- and inter-tumoral heterogeneity, resistance to treatment and dismal prognoses despite decades of research in understanding its biological underpinnings. Encompassed within this heterogeneity and therapy resistance are severely dysregulated programmed cell death pathways. Glioblastomas recapitulate many neurodevelopmental and neural injury responses; in addition, glioblastoma cells are composed of multiple different transformed versions of CNS cell types. To obtain a greater understanding of the features underlying cell death regulation in glioblastoma, it is important to understand the control of cell death within the healthy CNS during homeostatic and neurodegenerative conditions. Herein, we review apoptotic control within neural stem cells, astrocytes, oligodendrocytes and neurons and compare them to glioblastoma apoptotic control. Specific focus is paid to the Inhibitor of Apoptosis proteins, which play key roles in neuroinflammation, CNS cell survival and gliomagenesis. This review will help in understanding glioblastoma as a transformed version of a heterogeneous organ composed of multiple varied cell types performing different functions and possessing different means of apoptotic control. Further, this review will help in developing more glioblastoma-specific treatment approaches and will better inform treatments looking at more direct brain delivery of therapeutic agents.
         datePublished:2024-11-06T00:00:00Z
         dateModified:2024-11-06T00:00:00Z
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      headline:Cell death in glioblastoma and the central nervous system
      description:Glioblastoma is the commonest and deadliest primary brain tumor. Glioblastoma is characterized by significant intra- and inter-tumoral heterogeneity, resistance to treatment and dismal prognoses despite decades of research in understanding its biological underpinnings. Encompassed within this heterogeneity and therapy resistance are severely dysregulated programmed cell death pathways. Glioblastomas recapitulate many neurodevelopmental and neural injury responses; in addition, glioblastoma cells are composed of multiple different transformed versions of CNS cell types. To obtain a greater understanding of the features underlying cell death regulation in glioblastoma, it is important to understand the control of cell death within the healthy CNS during homeostatic and neurodegenerative conditions. Herein, we review apoptotic control within neural stem cells, astrocytes, oligodendrocytes and neurons and compare them to glioblastoma apoptotic control. Specific focus is paid to the Inhibitor of Apoptosis proteins, which play key roles in neuroinflammation, CNS cell survival and gliomagenesis. This review will help in understanding glioblastoma as a transformed version of a heterogeneous organ composed of multiple varied cell types performing different functions and possessing different means of apoptotic control. Further, this review will help in developing more glioblastoma-specific treatment approaches and will better inform treatments looking at more direct brain delivery of therapeutic agents.
      datePublished:2024-11-06T00:00:00Z
      dateModified:2024-11-06T00:00:00Z
      pageStart:313
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      license:http://creativecommons.org/licenses/by/4.0/
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         Apoptosis
         Necroptosis
         Glioblastoma
         Inhibitor of Apoptosis
         Astrocytes
         Oligodendrocytes
         Cancer Research
         Biomedicine
         general
         Pathology
         Oncology
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               type:PostalAddress
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            type:Organization
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      name:Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Canada
      name:Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada
      name:Apoptosis Research Centre, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
      name:Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Canada
      name:Apoptosis Research Centre, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada
      name:Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada
      name:Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Canada
      name:Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada

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