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Title:
Nanoparticle-based approaches for vascular inflammation in managing hypertension: advancing molecular mechanisms and treatment strategies | Drug Delivery and Translational Research
Description:
Hypertension is a global health challenge associated with significant morbidity and mortality resulting from vascular inflammation and endothelial dysfunction. Chronic hypertension is characterised by endothelial dysfunction, oxidative stress, immune cell recruitment, and cytokine release, all of which exacerbate vascular inflammation. Despite the availability of various antihypertensive therapies, limitations such as drug resistance and suboptimal targeting hinder their efficacy and reveal their side effects. Nanoparticle-based strategies could present innovative solutions by enabling precise drug delivery, minimising off-target effects, and enhancing therapeutic outcomes. Dual-targeting approaches that focus on molecular mechanistic pathways for managing hypertension using nanoparticle-based methods allow targeted modulation of inflammatory pathways as well. This advancement aids in redefining the management of vascular inflammation as a transformative frontier in antihypertensive therapy, addressing the unmet need for targeted, efficient, and patient-tailored treatment strategies. This review outlines the inflammatory pathophysiology underlying vascular hypertension and underscores the necessity of integrating knowledge gaps while inspiring innovative approaches to combat hypertension effectively. It concludes by identifying potential obstacles and solutions to overcome in order to successfully translate such nano-derived therapies into clinical practice applications. Graphical abstract
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, google, scholar, cas, central, drug, hypertension, delivery, vascular, endothelial, inflammation, nanoparticles, httpsdoiorgs, sci, med, cardiovascular, httpsdoiorg, review, cell, inflammatory, int, rev, treatment, disease, res, zhang, front, mol, therapy, pharmacol, targeted, oxide, dysfunction, targeting, therapeutic, diseases, role, immunol, cells, liu, deliv, mechanisms, applications, atherosclerosis, nat, van, study, nitric, inflammasome,

Topics {✒️}

22483/asset/db3fc274-d276-4b6d-ac76-bd094977914e/assets/graphic/hypertensionaha nm-afgf-loaded peg-nanoliposomes protects 3c00236/asset/images/large/au3c00236_0005 3c00032/asset/images/large/mg3c00032_0004 akt/gsk-3β1/nrf-2 pathway anti-vcam-1 saint-o-somes 2020/asset/images/large/aj-alun210004f001 at1r nox/ros/pp2a pathway pecam-1-targeted micron-sized particles nf-κb/cxcr7-dependent manner deoxycorticosterone acetate/salt-hypertensive mice liposomal-based anti-inflammatory therapy month download article/chapter t-cell-mediated actions tumor necrosis factor-α polymyxin b-modified liposomes polydopamine-assisted silver nanoparticle magnetic-based delivery systems improving nanoparticle-based drug endotoxin-induced pneumonia evaluated radiolabeled asn-gly-arg atorvastatin-loaded pegylated liposome aldosterone-sensitive distal nephron p-glycoprotein efflux pump ultra-sensitive molecular mri marcos-contreras oa endoglin/cd105-based imaging icam-1–directed immunoliposomes specifically antagonizing monocyte-mediated inflammation anti-inflammatory drug candidates nanotechnology-based carrier systems 9600198/asset/images/large/10 hypertensive end-organ damage inflammation-responsive micellar nanoparticles article drug delivery engineering nano-drug biointerface nanoparticle-based approaches nanotechnology-based drug carriers potent anti-inflammatory therapies patient-tailored treatment strategies balloon-dilated atherosclerotic arteries nitric oxide availability nanoparticle-based strategies nanotechnology-enabled health products 1146/annurev-immunol-081022-021207/cite/refworks nanoparticle-mediated delivery endothelium-derived vasoactive mediators nanoparticle-based methods activated endothelial cells p-selectin expression

Questions {❓}

Does the lack of the P-glycoprotein efflux pump in neutrophils explain the efficacy of colchicine in familial Mediterranean fever and other inflammatory diseases?
IL-1β and IL-18: inflammatory markers or mediators of hypertension?
Role for TNF in atherosclerosis?

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