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We are analyzing https://link.springer.com/article/10.1007/s12265-016-9683-3.

Title:
Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery | Journal of Cardiovascular Translational Research
Description:
To determine whether caspase-1 is critical in chronic kidney disease (CKD)-mediated arterial neointimal hyperplasia (NH), we utilized caspaseāˆ’/āˆ’ mice and induced NH in carotid artery in a CKD environment, and uremic sera-stimulated human vascular smooth muscle cells (VSMC). We made the following findings: (1) Caspase-1 inhibition corrected uremic sera-mediated downregulation of VSMC contractile markers, (2) CKD-promoted NH was attenuated in caspaseāˆ’/āˆ’ mice, (3) CKD-mediated downregulation of contractile markers was rescued in caspase null mice, and (4) expression of VSMC migration molecule αvβ3 integrin was reduced in caspaseāˆ’/āˆ’ tissues. Our results suggested that caspase-1 pathway senses CKD metabolic danger signals. Further, CKD-mediated increase of contractile markers in VSMC and increased expression of VSMC migration molecule αvβ3 integrin in NH formation were caspase-1 dependent. Therefore, caspase-1 is a novel therapeutic target for the suppression of CKD-promoted NH.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Education
  • Health & Fitness
  • Science

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {šŸ’ø}

We're unsure if the website is profiting.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {šŸ”}

article, pubmed, research, google, scholar, support, cas, kidney, disease, vascular, govt, journal, caspase, chronic, nonus, central, cardiovascular, neointimal, access, review, nih, extramural, hyperplasia, smooth, muscle, mice, american, ferrer, monroy, vsmc, cell, choi, ckd, medicine, nephrology, lee, privacy, cookies, content, critical, artery, lopezpastrana, wang, cells, atherosclerosis, yin, university, temple, information, publish,

Topics {āœ’ļø}

end-stage renal disease month download article/chapter nlrp3/asc inflammasome-mediated activation xiao-feng yangĀ &Ā eric chronic kidney disease chronic renal failure p-selectin-deficient mice xiao-feng yang ckd-mediated downregulation full article pdf guideline practice guideline american heart association venous neointimal hyperplasia related subjects metabolic disease research caspase-1-sirtuin 1 pathway ya-feng li ckd-mediated increase privacy choices/manage cookies ckd-promoted nh bone marrow apoptosis kidney diseases pulmonary vascular remodeling inflammasome adaptor molecule kidney disease dialysis access stenosis jahaira lopez-pastrana utilized caspaseāˆ’/āˆ’ mice caspase null mice cardiovascular translational research vascular access cardiovascular phenotype european economic area altered cytokine export superoxide dismutase mimetic lewis katz school north broad street biophysical research communications conditions privacy policy ckd accelerates development nature reviews cancer ethics declarations funding editorial research support article log cardiovascular mortality accepting optional cookies sudden coronary death extramural research support cell increases cardiovascular disease

Questions {ā“}

  • Imaging subclinical atherosclerosis: is it ready for prime time?

Schema {šŸ—ŗļø}

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         headline:Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery
         description:To determine whether caspase-1 is critical in chronic kidney disease (CKD)-mediated arterial neointimal hyperplasia (NH), we utilized caspaseāˆ’/āˆ’ mice and induced NH in carotid artery in a CKD environment, and uremic sera-stimulated human vascular smooth muscle cells (VSMC). We made the following findings: (1) Caspase-1 inhibition corrected uremic sera-mediated downregulation of VSMC contractile markers, (2) CKD-promoted NH was attenuated in caspaseāˆ’/āˆ’ mice, (3) CKD-mediated downregulation of contractile markers was rescued in caspase null mice, and (4) expression of VSMC migration molecule αvβ3 integrin was reduced in caspaseāˆ’/āˆ’ tissues. Our results suggested that caspase-1 pathway senses CKD metabolic danger signals. Further, CKD-mediated increase of contractile markers in VSMC and increased expression of VSMC migration molecule αvβ3 integrin in NH formation were caspase-1 dependent. Therefore, caspase-1 is a novel therapeutic target for the suppression of CKD-promoted NH.
         datePublished:2016-02-29T00:00:00Z
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      headline:Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery
      description:To determine whether caspase-1 is critical in chronic kidney disease (CKD)-mediated arterial neointimal hyperplasia (NH), we utilized caspaseāˆ’/āˆ’ mice and induced NH in carotid artery in a CKD environment, and uremic sera-stimulated human vascular smooth muscle cells (VSMC). We made the following findings: (1) Caspase-1 inhibition corrected uremic sera-mediated downregulation of VSMC contractile markers, (2) CKD-promoted NH was attenuated in caspaseāˆ’/āˆ’ mice, (3) CKD-mediated downregulation of contractile markers was rescued in caspase null mice, and (4) expression of VSMC migration molecule αvβ3 integrin was reduced in caspaseāˆ’/āˆ’ tissues. Our results suggested that caspase-1 pathway senses CKD metabolic danger signals. Further, CKD-mediated increase of contractile markers in VSMC and increased expression of VSMC migration molecule αvβ3 integrin in NH formation were caspase-1 dependent. Therefore, caspase-1 is a novel therapeutic target for the suppression of CKD-promoted NH.
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      dateModified:2016-02-29T00:00:00Z
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                     name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
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            name:Ya-feng Li
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                     name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
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               name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
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               name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
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      name:Hong Wang
      affiliation:
            name:Lewis Katz School of Medicine, Temple University
            address:
               name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Lewis Katz School of Medicine, Temple University
            address:
               name:Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      name:Xiao-feng Yang
      affiliation:
            name:Lewis Katz School of Medicine, Temple University
            address:
               name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Lewis Katz School of Medicine, Temple University
            address:
               name:Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Eric T. Choi
      affiliation:
            name:Lewis Katz School of Medicine, Temple University
            address:
               name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
               type:PostalAddress
            type:Organization
            name:Lewis Katz School of Medicine, Temple University
            address:
               name:Department of Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Department of Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Department of Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Centers for Metabolic Disease Research, Cardiovascular Research and Thrombosis Research, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
      name:Department of Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, USA
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