
NCBI . NLM . NIH . GOV {
}
Title[redir]:
Integrins in cancer: biological implications and therapeutic opportunities - PMC
Description:
The integrin family of cell adhesion receptors regulates a diverse array of cellular functions crucial to the initiation, progression and metastasis of solid tumours. The importance of integrins in several cell types that affect tumour progression ...
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Keywords {🔍}
doi, integrin, tumour, google, scholar, pubmed, cell, cancer, cells, integrins, αvβ, growth, pmc, article, free, factor, angiogenesis, survival, signalling, expression, metastasis, receptor, res, progression, activation, tumours, studies, increased, breast, adhesion, role, endothelial, patients, phase, human, tumor, invasion, receptors, antagonists, biol, cilengitide, migration, apoptosis, crosstalk, clin, clinical, glioblastoma, effects, bone, antibody,
Topics {✒️}
arginine-glycine-aspartic acid-lysine cyclic arginine-glycine-aspartic acid caveolae/raft-dependent endocytic pathway integrin-regulated fak-src signaling transforming growth factor-β promote pro-apoptotic cascades bone marrow-derived cells increasing anchorage-independent survival cell-free receptor assay regulates tgf-β stimulation pmc beta search increased anchorage-independence small-cell lung carcinoma suppresses integrin-mediated activation kras-g12d-induced tumours requires src-dependent phosphorylation function-blocking monoclonal antibodies anchorage-independent growth tnf-related apoptosis-inducing ligand mammary epithelial-specific disruption integrin αvβ3-targeted radioimmunotherapy urokinase-type plasminogen activator o-6-methylguanine-dna methyltransferase nf-κb-dependent pathway targeted erbb2-specific therapy66 function-blocking monoclonal antibody integrin αvβ3-targeted nanoparticle src-pl 30cas pathway99 mammary epithelial-specific ablation places anti-integrin therapy f-box protein skp2 src-dependent tyrosine phosphorylation deconstructing agonist-induced activation integrin αv-mediated inactivation nanoparticle-mediated drug delivery increased nuclear factor-κb pro-tumorigenic integrin αvβ3 delivery of18f-galacto-rgd vx-2 rabbit adenocarcinoma fak-independent survival pathway ligand-mediated integrin clustering integrin αvβ3-targeted therapy shp2-src signaling pathway integrin αvβ3-mediated activation solid-state gamma-camera integrin αvβ3-expressing tumours proto-oncogene wnt1 caused rgd-peptidomimetic agents s137 rgd-based peptide inhibitor integrin-mediated cell migration
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- What's the profit of https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Oncol&title=Phase%20I%20and%20correlative%20biology%20study%20of%20cilengitide%20in%20patients%20with%20recurrent%20malignant%20glioma&author=LB%20Nabors&volume=25&publication_year=2007&pages=1651-1657&pmid=17470857&doi=10.1200/JCO.2006.06.6514&?
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- https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Oncol&title=Phase%20I%20clinical%20trial%20of%20cilengitide%20in%20children%20with%20refractory%20brain%20tumors:%20pediatric%20brain%20tumor%20consortium%20study%20PBTC-012&author=TJ%20MacDonald&volume=26&publication_year=2008&pages=919-924&pmid=18281665&doi=10.1200/JCO.2007.14.1812& income
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- What's https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Oncol&title=Randomized%20phase%20II%20study%20of%20cilengitide,%20an%20integrin-targeting%20arginine-glycine-aspartic%20acid%20peptide,%20in%20recurrent%20glioblastoma%20multiforme&author=DA%20Reardon&volume=26&publication_year=2008&pages=5610-5617&pmid=18981465&doi=10.1200/JCO.2008.16.7510&'s gross income?
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- How much does https://scholar.google.com/scholar_lookup?journal=J.%20Clin,%20Oncol&title=Phase%20I/IIa%20trial%20of%20cilengitide%20(EMD121974)%20and%20temozolomide%20with%20concomitant%20radiotherapy,%20followed%20by%20temozolomide%20and%20cilengitide%20maintenance%20therapy%20in%20patients%20(pts)%20with%20newly%20diagnosed%20glioblastoma%20(GBM)&author=R%20Stupp&volume=25&issue=18S&publication_year=2007&pages=2000&pmid=20439646&doi=10.1200/JCO.2009.26.6650& net monthly?
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- https://doi.org/10.1242/jcs.114.8.1545 income
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Sci&title=Superactivation%20of%20integrin%20%CE%B1v%CE%B23%20by%20low%20antagonist%20concentrations&author=DF%20Legler&author=G%20Wiedle&author=FP%20Ross&author=BA%20Imhof&volume=114&publication_year=2001&pages=1545-1553&pmid=11282030&doi=10.1242/jcs.114.8.1545&?
- What's the profit of https://doi.org/10.1083/jcb.110.4.1427?
- What's the income generated by https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Biol&title=Signal%20transduction%20for%20chemotaxis%20and%20haptotaxis%20by%20matrix%20molecules%20in%20tumor%20cells&author=S%20Aznavoorian&author=ML%20Stracke&author=H%20Krutzsch&author=E%20Schiffmann&author=LA%20Liotta&volume=110&publication_year=1990&pages=1427-1438&pmid=2324200&doi=10.1083/jcb.110.4.1427& each month?
- https://doi.org/10.1016/j.ccr.2009.01.021 income
- How much revenue does https://scholar.google.com/scholar_lookup?journal=Cancer%20Cell&title=Accelerated%20metastasis%20after%20shortterm%20treatment%20with%20a%20potent%20inhibitor%20of%20tumor%20angiogenesis&author=JM%20Ebos&volume=15&publication_year=2009&pages=232-239&pmid=19249681&doi=10.1016/j.ccr.2009.01.021& produce monthly?
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- What are the total earnings of https://doi.org/10.1227/01.NEU.0000245622.70344.BE?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Neurosurgery&title=Effect%20of%20the%20angiogenesis%20inhibitor%20Cilengitide%20(EMD%20121974)%20on%20glioblastoma%20growth%20in%20nude%20mice&author=S%20Yamada&volume=59&publication_year=2006&pages=1304-1312&pmid=17277694&doi=10.1227/01.NEU.0000245622.70344.BE&?
- How much profit is https://doi.org/10.1172/JCI115516 making per month?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Invest&title=Glioblastoma%20expression%20of%20vitronectin%20and%20the%20%CE%B1v%CE%B2%203%20integrin.%20Adhesion%20mechanism%20for%20transformed%20glial%20cells&author=CL%20Gladson&author=DA%20Cheresh&volume=88&publication_year=1991&pages=1924-1932&pmid=1721625&doi=10.1172/JCI115516&?
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- How much money does https://scholar.google.com/scholar_lookup?journal=Curr.%20Opin.%20Mol.%20Ther&title=Drug%20evaluation:%20Volociximab,%20an%20angiogenesis-inhibiting%20chimeric%20monoclonal%20antibody&author=SK%20Kuwada&volume=9&publication_year=2007&pages=92-98&pmid=17330407& generate?
- How much profit does https://doi.org/10.1158/1535-7163.MCT-06-0100 generate?
- How much income is https://scholar.google.com/scholar_lookup?journal=Mol.%20Cancer%20Ther&title=A%20non-RGD-based%20integrin%20binding%20peptide%20(ATN-161)%20blocks%20breast%20cancer%20growth%20and%20metastasis%20in%20vivo&author=P%20Khalili&volume=5&publication_year=2006&pages=2271-2280&pmid=16985061&doi=10.1158/1535-7163.MCT-06-0100& earning monthly?
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- Revenue of https://scholar.google.com/scholar_lookup?journal=Int.%20J.%20Cancer&title=Inhibition%20of%20integrin%20%CE%B15%CE%B21%20function%20with%20a%20small%20peptide%20(ATN-161)%20plus%20continuous%205-FU%20infusion%20reduces%20colorectal%20liver%20metastases%20and%20improves%20survival%20in%20mice&author=O%20Stoeltzing&volume=104&publication_year=2003&pages=496-503&pmid=12584749&doi=10.1002/ijc.10958&
- https://doi.org/10.1038/sj.bjc.6603171 income
- How much money does https://scholar.google.com/scholar_lookup?journal=Br.%20J.%20Cancer&title=Phase%201%20trial%20of%20the%20antiangiogenic%20peptide%20ATN-161%20(Ac-PHSCN-NH2),%20a%20beta%20integrin%20antagonist,%20in%20patients%20with%20solid%20tumours&author=ME%20Cianfrocca&volume=94&publication_year=2006&pages=1621-1626&pmid=16705310&doi=10.1038/sj.bjc.6603171& make?
- How much does https://doi.org/10.1023/b:clin.0000024763.69809.64 bring in each month?
- https://scholar.google.com/scholar_lookup?journal=Clin.%20Exp.%20Metastasis&title=A%20small%20molecule%20antagonist%20of%20the%20%CE%B1v%CE%B23%20integrin%20suppresses%20MDA-MB-435%20skeletal%20metastasis&author=JF%20Harms&volume=21&publication_year=2004&pages=119-128&pmid=15168729&doi=10.1023/b:clin.0000024763.69809.64&'s total income per month
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=%CE%B1v%CE%B23%20integrin%20antagonist%20S247%20decreases%20colon%20cancer%20metastasis%20and%20angiogenesis%20and%20improves%20survival%20in%20mice&author=N%20Reinmuth&volume=63&publication_year=2003&pages=2079-2087&pmid=12727823&
- What's the financial gain of https://doi.org/10.1158/0008-5472.CAN-06-4499?
- Revenue of https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Tumor%20%CE%B1v%CE%B23%20integrin%20is%20a%20therapeutic%20target%20for%20breast%20cancer%20bone%20metastases&author=Y%20Zhao&volume=67&publication_year=2007&pages=5821-5830&pmid=17575150&doi=10.1158/0008-5472.CAN-06-4499&
- How much does https://doi.org/10.1023/b:clin.0000024764.93092.5f make?
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Clin.%20Exp.%20Metastasis&title=Anti-metastatic%20properties%20of%20RGD-peptidomimetic%20agents%20S137%20and%20S247&author=KE%20Shannon&volume=21&publication_year=2004&pages=129-138&pmid=15168730&doi=10.1023/b:clin.0000024764.93092.5f&?
- What is the earnings of https://doi.org/10.1016/j.dld.2007.01.025?
- How much does https://scholar.google.com/scholar_lookup?journal=Dig.%20Liver%20Dis&title=Antisense%20integrin%20%CE%B1V%20and%20%CE%B23%20gene%20therapy%20suppresses%20subcutaneously%20implanted%20hepatocellular%20carcinomas&author=J%20Li&volume=39&publication_year=2007&pages=557-565&pmid=17374519&doi=10.1016/j.dld.2007.01.025& generate monthly?
- How much revenue does https://doi.org/10.1038/nm0598-623 generate?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Nature%20Med&title=Detection%20of%20tumor%20angiogenesis%20in%20vivo%20by%20%CE%B1V%CE%B23-targeted%20magnetic%20resonance%20imaging&author=DA%20Sipkins&volume=4&publication_year=1998&pages=623-626&pmid=9585240&doi=10.1038/nm0598-623&?
- How much revenue does https://doi.org/10.1158/0008-5472.CAN-06-1480 produce monthly?
- What's https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=In%20vitro%20and%20in%20vivo%20characterization%20of%2064Cu-labeled%20Abegrin,%20a%20humanized%20monoclonal%20antibody%20against%20integrin%20%CE%B1v%CE%B23&author=W%20Cai&volume=66&publication_year=2006&pages=9673-9681&pmid=17018625&doi=10.1158/0008-5472.CAN-06-1480&'s gross income?
- How much money does https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Molecular%20imaging%20of%20angiogenesis%20in%20nascent%20Vx-2%20rabbit%20tumors%20using%20a%20novel%20%CE%B1%CE%BD%CE%B23-%20targeted%20nanoparticle%20and%201.5%20tesla%20magnetic%20resonance%20imaging&author=PM%20Winter&volume=63&publication_year=2003&pages=5838-5843&pmid=14522907& make?
- How much profit does https://doi.org/10.1161/01.cir.0000044916.05919.8b make?
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Circulation&title=Noninvasive%20assessment%20of%20angiogenesis%20by%20ultrasound%20and%20microbubbles%20targeted%20to%20%CE%B1v-integrins&author=H%20Leong-Poi&author=J%20Christiansen&author=AL%20Klibanov&author=S%20Kaul&author=JR%20Lindner&volume=107&publication_year=2003&pages=455-460&pmid=12551871&doi=10.1161/01.cir.0000044916.05919.8b&?
- How much does https://doi.org/10.1016/j.mibio.2004.06.004 pull in monthly?
- How much income does https://scholar.google.com/scholar_lookup?journal=Mol.%20Imaging%20Biol&title=MicroPET%20imaging%20of%20breast%20cancer%20%CE%B1v-integrin%20expression%20with%2064Cu-labeled%20dimeric%20RGD%20peptides&author=X%20Chen&volume=6&publication_year=2004&pages=350-359&pmid=15380745&doi=10.1016/j.mibio.2004.06.004& have?
- What's the financial intake of https://doi.org/10.1007/s00259-003-1452-2?
- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Eur.%20J.%20Nucl.%20Med.%20Mol.%20Imaging&title=MicroPET%20imaging%20of%20brain%20tumor%20angiogenesis%20with%2018F-labeled%20PEGylated%20RGD%20peptide&author=X%20Chen&volume=31&publication_year=2004&pages=1081-1089&pmid=15118844&doi=10.1007/s00259-003-1452-2& have monthly?
- How much does https://doi.org/10.1158/0008-5472.CAN-06-1668 pull in monthly?
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Cancer%20Res&title=Specific%20targeting%20of%20tumor%20angiogenesis%20by%20RGD-conjugated%20ultrasmall%20superparamagnetic%20iron%20oxide%20particles%20using%20a%20clinical%201.5-T%20magnetic%20resonance%20scanner&author=C%20Zhang&volume=67&publication_year=2007&pages=1555-1562&pmid=17308094&doi=10.1158/0008-5472.CAN-06-1668&
- What is the monthly revenue of https://doi.org/10.1111/j.1475-097X.2008.00801.x?
- Learn how profitable https://scholar.google.com/scholar_lookup?journal=Clin.%20Physiol.%20Funct.%20Imaging&title=Integrin%20scintimammography%20using%20a%20dedicated%20breast%20imaging,%20solid-state%20gamma-camera%20and%20(99m)%20Tc-labelled%20NC100692&author=T%20Bach-Gansmo&author=TV%20Bogsrud&author=A%20Skretting&volume=28&publication_year=2008&pages=235-239&pmid=18384623&doi=10.1111/j.1475-097X.2008.00801.x& is on a monthly basis
- https://scholar.google.com/scholar_lookup?journal=J.%20Nucl.%20Med&title=Integrin%20receptor%20imaging%20of%20breast%20cancer:%20a%20proof-of-concept%20study%20to%20evaluate%2099mTc-NC100692&author=T%20Bach-Gansmo&volume=47&publication_year=2006&pages=1434-1439&pmid=16954550&'s total income per month
- How much income does https://doi.org/10.1371/journal.pmed.0020070 have?
- What's the profit of https://scholar.google.com/scholar_lookup?journal=PLoS%20Med&title=Noninvasive%20visualization%20of%20the%20activated%20%CE%B1v%CE%B23%20integrin%20in%20cancer%20patients%20by%20positron%20emission%20tomography%20and%20%5B18F%5DGalacto-RGD&author=R%20Haubner&volume=2&publication_year=2005&pages=e70&pmid=15783258&doi=10.1371/journal.pmed.0020070&?
- What's https://doi.org/10.1073/pnas.0803728105's gross income?
- https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl%20Acad.%20Sci.%20USA&title=Nanoparticle-mediated%20drug%20delivery%20to%20tumor%20vasculature%20suppresses%20metastasis&author=EA%20Murphy&volume=105&publication_year=2008&pages=9343-9348&pmid=18607000&doi=10.1073/pnas.0803728105&'s total income per month
- What's the monthly income of https://doi.org/10.1038/sj.onc.1210770?
- Find out how much https://scholar.google.com/scholar_lookup?journal=Oncogene&title=Distinct%20FAK-Src%20activation%20events%20promote%20%CE%B15%CE%B21%20and%20%CE%B14%CE%B21%20integrin-stimulated%20neuroblastoma%20cell%20motility&author=L%20Wu&volume=27&publication_year=2008&pages=1439-1448&pmid=17828307&doi=10.1038/sj.onc.1210770& earns monthly
- Discover the revenue of https://doi.org/10.1083/jcb.200609004
- How much money does https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Biol&title=%CE%B1v%CE%B23%20and%20%CE%B15%CE%B21%20integrin%20recycling%20pathways%20dictate%20downstream%20Rho%20kinase%20signaling%20to%20regulate%20persistent%20cell%20migration&author=DP%20White&author=PT%20Caswell&author=JC%20Norman&volume=177&publication_year=2007&pages=515-525&pmid=17485491&doi=10.1083/jcb.200609004& make?
- How much does https://doi.org/10.1242/jcs.017012 gross monthly?
- Earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Sci&title=Rac-dependent%20cyclin%20D1%20gene%20expression%20regulated%20by%20cadherin-%20and%20integrinmediated%20adhesion&author=AK%20Fournier&volume=121&publication_year=2008&pages=226-233&pmid=18187454&doi=10.1242/jcs.017012&
- Income figures for https://doi.org/10.1083/jcb.153.7.1381
- Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Cell%20Biol&title=Role%20of%20the%20F-box%20protein%20Skp2%20in%20adhesion-dependent%20cell%20cycle%20progression&author=AC%20Carrano&author=M%20Pagano&volume=153&publication_year=2001&pages=1381-1390&pmid=11425869&doi=10.1083/jcb.153.7.1381&
- What's the total monthly financial gain of https://doi.org/10.1016/s0002-9440(10)65730-6?
- How much profit does https://scholar.google.com/scholar_lookup?journal=Am.%20J.%20Pathol&title=Adenoviral%20gene%20transfer%20of%20%CE%B23%20integrin%20subunit%20induces%20conversion%20from%20radial%20to%20vertical%20growth%20phase%20in%20primary%20human%20melanoma&author=MY%20Hsu&volume=153&publication_year=1998&pages=1435-1442&pmid=9811334&doi=10.1016/s0002-9440(10)65730-6& generate?
- How much money does https://doi.org/10.1002/(sici)1097-0142(19990115)85:2<375::aid-cncr15>3.0.co;2-1 make?
- Learn how profitable https://scholar.google.com/scholar_lookup?journal=Cancer&title=Molecular%20prognostic%20markers%20in%20intermediate-thickness%20cutaneous%20malignant%20melanoma&author=TJ%20Hieken&author=SG%20Ronan&author=M%20Farolan&author=AL%20Shilkaitis&author=TK%20Das%20Gupta&volume=85&publication_year=1999&pages=375-382&pmid=10023705&doi=10.1002/(sici)1097-0142(19990115)85:2<375::aid-cncr15>3.0.co;2-1& is on a monthly basis
- Revenue of https://doi.org/10.1111/j.1365-2559.1994.tb00517.x
- What's the total monthly financial gain of https://scholar.google.com/scholar_lookup?journal=Histopathology&title=Emergence%20of%20%CE%B15%CE%B21%20fibronectin-%20and%20%CE%B1v%CE%B23%20vitronectin-receptor%20expression%20in%20melanocytic%20tumour%20progression&author=EH%20Danen&volume=24&publication_year=1994&pages=249-256&pmid=7515372&doi=10.1111/j.1365-2559.1994.tb00517.x&?
- How much does https://doi.org/10.1172/JCI116007 generate monthly?
- How much revenue does https://scholar.google.com/scholar_lookup?journal=J.%20Clin.%20Invest&title=Human%20melanoma%20cells%20derived%20from%20lymphatic%20metastases%20use%20integrin%20%CE%B1v%CE%B23%20to%20adhere%20to%20lymph%20node%20vitronectin&author=J%20Nip&author=H%20Shibata&author=DJ%20Loskutoff&author=DA%20Cheresh&author=P%20Brodt&volume=90&publication_year=1992&pages=1406-1413&pmid=1383272&doi=10.1172/JCI116007& bring in?
- Monthly income for https://doi.org/10.1038/modpathol.3800411
- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Mod.%20Pathol&title=%CE%B24%20integrin%20subunit%20gene%20expression%20correlates%20with%20tumor%20size%20and%20nuclear%20grade%20in%20early%20breast%20cancer&author=LK%20Diaz&volume=18&publication_year=2005&pages=1165-1175&pmid=15920552&doi=10.1038/modpathol.3800411&
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- https://doi.org/10.1158/0008-5472.CAN-08-2678 income
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