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Title[redir]:
CASPASE-1 RECOGNIZES EXTENDED CLEAVAGE SITES IN ITS NATURAL SUBSTRATES - PMC
Description:
The preferred amino acids in the proteolytic sites have been considered to be similar between caspase-1 and caspase-9, which do not support their differential functions in inflammatory pyroptosis and apoptosis. We attempted to solve this problem. We ...
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Keywords {🔍}
caspase, amino, substrates, cleavage, acid, sites, pmid, doi, frequencies, site, table, positions, caspases, occurrence, significant, acids, google, scholar, cut, position, pubmed, identified, protein, patterns, cell, experimentally, human, apoptosis, confidential, residues, prediction, death, intervals, group, matches, pmc, pyroptosis, flanking, activation, predicted, higher, hydrophobic, inflammation, percentages, results, proteins, substrate, section, extended, article,
Topics {✒️}
pamp-rs-caspase-1-il-1β pathway flanking regions p10…p1-p1′-p10′ bulky x-glu-x-asp p10…p1-p1′…p10′ regions death receptor/disc-activated caspase-8 c-terminal flanking regions nf-kappab signaling system pamp-receptor families4 leads nf-κb pathway serves pmc beta search precursors pro-il-1β /apoptosome-activated caspase-9 pathway upregulating anti-apoptotic proteins sense pro-apoptotic stimuli flanking regions extended proinflammatory cytokines il-1β caspase-1-dependent inflammatory pyroptosis cleavage sites p1-p1′ nat rev microbiol p10-p10′ positions p10-p10′ region substrates including pro-caspase-1 highest occurrence frequencies x-e-x primary structural features amino acid pairs mol cell proteomics experimentally identified substrates amino acid residues p1 amino acid amino acid positions anti-apoptotic protein amino acid frequency amino acid matches inflammatory cell death compared occurrence frequencies ubiquitin-protein ligase license information pmcid supplementary materials included experimental therapeutic agents cleavage site patterns cleavage site positions amino acid preferences charged amino acids cell death aspect host cell death cell death programmes cell death differ proteomics protocols handbook amino acid features
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