We are analyzing https://link.springer.com/article/10.1007/s11010-024-04978-2.

Title:
Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies | Molecular and Cellular Biochemistry
Description:
Ferroptosis is a newly discovered type of regulated cell death participated in multiple diseases. Different from other classical cell death programs such as necrosis and apoptosis, ferroptosis involving iron-catalyzed lipid peroxidation is characterized by Fe2+ accumulation and mitochondria alterations. The phenomenon of oxidative stress following organ ischemia–reperfusion (I/R) has recently garnered attention for its connection to the onset of ferroptosis and subsequent reperfusion injuries. This article provides a comprehensive overview underlying the mechanisms of ferroptosis, with a further focus on the latest research progress regarding interference with ferroptotic pathways in organ I/R injuries, such as intestine, lung, heart, kidney, liver, and brain. Understanding the links between ferroptosis and I/R injury may inform potential therapeutic strategies and targeted agents.
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Keywords {🔍}

pubmed, article, google, scholar, cas, ferroptosis, injury, central, ischemiareperfusion, wang, zhang, cell, liu, yang, chen, death, med, httpsdoiorgs, acute, zhao, biol, sci, kidney, zhou, httpsdoiorg, mol, myocardial, iron, sun, liver, acid, lipid, physiol, res, alleviates, mechanisms, lung, receptor, heme, renal, ischemic, cerebral, front, role, stroke, tang, cells, int, attenuates, peng,

Topics {✒️}

ischemia-reperfusion-induced intestinal injury intestinal ischemia/reperfusion-induced injury month download article/chapter renal ischemia-reperfusion injury cerebral ischemia/reperfusion injury myocardial ischaemia-reperfusion injury hepatic ischemia-reperfusion injury hepatic ischemia/reperfusion injury regulating gpx4/acsl4/acsl3 axis attenuate ischemia-reperfusion injury myocardial ischemia-reperfusion injury myocardial ischemia/reperfusion injury ischemia/reperfusion cardiac injury cerebral ischemia-induced ferroptosis organ ischemia-reperfusion injury ischemia-induced myocardial damage organ ischemia–reperfusion injuries ferroptosis-mediated tissue injury cysteine/glutamate transporter slc3a2 ischaemia-reperfusion injury jak/stat signaling activation cystine/glutamate antiporter system regulate ascl4-mediated ferroptosis il-6/stat3/gpx4 signaling voltage-gated ion channels cox-2/pge2 pathway inhibits l-β-aminoisobutyric acid inhibits ros-mediated apoptosis nucleotide-binding oligomerization domain facilitating chaperone-mediated autophagy cerebral ischemia reperfusion cerebral ischemia/reperfusion ischemia-reperfusion injury ischemia/reperfusion injury apigenin-7-o-β-d tnf-α/nox2 pathway nrf-2/ho-1 signaling axis nrf2/slc7a11 signaling axis attenuated st-segment elevation intestinal ischemia/reperfusion intestinal ischemia reperfusion enhanced ros-based therapy tubular epithelial cells suppressing gpx4-mediated ferroptosis myocardial ischemia-reperfusion nrf2/ho-1 signal axis bone mineral density long-term impacts nrf2/slc7a11/ho-1 axis organ ischemia–reperfusion

Questions {❓}

Stoyanovsky DA, Tyurina YY, Shrivastava I, Bahar I, Tyurin VA, Protchenko O, Jadhav S, Bolevich SB, Kozlov AV, Vladimirov YA, Shvedova AA, Philpott CC, Bayir H, Kagan VE (2019) Iron catalysis of lipid peroxidation in ferroptosis: regulated enzymatic or random free radical reaction?

Schema {🗺️}

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      description:Ferroptosis is a newly discovered type of regulated cell death participated in multiple diseases. Different from other classical cell death programs such as necrosis and apoptosis, ferroptosis involving iron-catalyzed lipid peroxidation is characterized by Fe2+ accumulation and mitochondria alterations. The phenomenon of oxidative stress following organ ischemia–reperfusion (I/R) has recently garnered attention for its connection to the onset of ferroptosis and subsequent reperfusion injuries. This article provides a comprehensive overview underlying the mechanisms of ferroptosis, with a further focus on the latest research progress regarding interference with ferroptotic pathways in organ I/R injuries, such as intestine, lung, heart, kidney, liver, and brain. Understanding the links between ferroptosis and I/R injury may inform potential therapeutic strategies and targeted agents.
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