We are analyzing https://link.springer.com/article/10.1007/s10555-015-9594-9.

Title:
Neutrophils: important contributors to tumor progression and metastasis | Cancer and Metastasis Reviews
Description:
The presence of neutrophils in tumors has traditionally been considered to be indicative of a failed immune response against cancers. However, there is now evidence showing that neutrophils can promote tumor growth, and increasingly, the data support an active role for neutrophils in tumor progression to distant metastasis. Neutrophils have been implicated in promoting metastasis in cancer patients, where neutrophil numbers and neutrophil-related factors and functions have been associated with progressive disease. Nevertheless, the role of neutrophils in tumors, both at the primary and secondary sites, remains controversial, with some studies reporting their anti-tumor functions. This review will focus on the data demonstrating a role for neutrophils in both tumor growth and metastasis and will attempt to clarify the discrepancies in the literature.
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Keywords {🔍}

pubmed, google, scholar, cas, article, cancer, journal, neutrophils, central, cells, tumor, cell, immunology, research, neutrophil, metastasis, role, growth, nature, human, inflammation, breast, international, angiogenesis, reviews, progression, biology, macrophages, lung, clinical, factor, patients, tumour, myeloid, blood, van, pathology, interleukin, tumorassociated, survival, leukocyte, suppressor, ratio, adenocarcinoma, polymorphonuclear, national, murine, american, immune, promote,

Topics {✒️}

granulocyte-macrophage colony-stimulating factor gr-1 + cd11b + myeloid cells tip granulocyte colony-stimulating factor antibody-dependent cell-mediated cytotoxicity g-csf-induced neutrophil recruitment anti-csf-1r antibody reveals tumor necrosis factor-alpha myeloid-derived suppressor cells month download article/chapter antigen-specific t-cell responses g-csf-nonproducing tumor cells pubmed google scholar complement-derived chemotactic factor free-form neutrophil elastase develop pro-tumorigenic properties csf-1r/csf-1 signaling transforming growth factor-alpha myxoid/round cell liposarcoma granulocyte-derived hydrogen peroxide neutrophil elastase-mediated degradation chemokine-mediated rapid turnover tissue-infiltrating neutrophils constitute enzymatic activity-dependent induction tumor-elicited polymorphonuclear cells mouse bone marrow cytokine-treated human neutrophils membrane-bound tgf-beta 1 cell-mediated immune response fresh human complement—role granulocyte-differentiation antigen full article pdf granulocyte/lymphocyte ratio ly6c/ly6g-based strategy catalytic site-independent binding granulocyte chemotactic protein-2 syngeneic rat tumour natural killer cells g-csf receptor immature myeloid cells myeloid lineage cells t-cell function nitric oxide synthase neutrophil-derived proteins tumor angiogenesis induced privacy choices/manage cookies extracellular matrix breakdown tumor-derived factors improve host immunosurveillance rat sarcoma cells pancreatic ductal adenocarcinoma

Questions {❓}

Inflammation and cancer: back to Virchow?
Tumor-associated neutrophils: friend or foe?

Schema {🗺️}

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         description:The presence of neutrophils in tumors has traditionally been considered to be indicative of a failed immune response against cancers. However, there is now evidence showing that neutrophils can promote tumor growth, and increasingly, the data support an active role for neutrophils in tumor progression to distant metastasis. Neutrophils have been implicated in promoting metastasis in cancer patients, where neutrophil numbers and neutrophil-related factors and functions have been associated with progressive disease. Nevertheless, the role of neutrophils in tumors, both at the primary and secondary sites, remains controversial, with some studies reporting their anti-tumor functions. This review will focus on the data demonstrating a role for neutrophils in both tumor growth and metastasis and will attempt to clarify the discrepancies in the literature.
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