Here's how LINK.SPRINGER.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s10549-017-4113-z.

Title:
Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer | Breast Cancer Research and Treatment
Description:
Intra-tumor heterogeneity (ITH) plays a pivotal role in driving breast cancer progression and therapeutic resistance. We used a mutant-allele tumor heterogeneity (MATH) algorithm to measure ITH and explored its correlation with clinical parameters and multi-omics data. We assessed 916 female breast cancer patients from The Cancer Genome Atlas. We calculated the MATH values from whole-exome sequencing data and further investigated their correlation with clinical characteristics, somatic mutations, somatic copy number alterations (SCNAs), and gene enrichment. The patients were divided into low, intermediate, and high MATH groups. High T stage, African American race, and triple-negative or basal-like subtype were associated with a higher MATH level (all P < 0.001). In hormone receptor-positive and human epidermal growth factor receptor-negative patients, the high MATH group showed a tendency toward a worse overall survival (P = 0.052); Furthermore, the TP53 mutation rate increased as MATH was elevated (P < 0.001), whereas CDH1 mutations were correlated with a lower level of MATH (P = 0.002). Several focal and arm-level SCNA events were more common in the high MATH group (P < 0.05), including Chr8q24 with only the MYC gene in the ā€œpeakā€ region. Similarly, high MATH was associated with gene set enrichment related to the MYC pathway and proliferation. Our integrative analysis reveals the clinical and genetic relevance of ITH in breast cancer. These results also suggest the origin and natural history of clonal evolution and intra-tumor genetic heterogeneity, which warrant further investigation.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Education
  • Science
  • Health & Fitness

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,626,432 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {šŸ’ø}

We can't figure out the monetization strategy.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {šŸ”}

pubmed, article, cancer, google, scholar, breast, heterogeneity, cas, central, supplementary, material, genetic, math, analysis, data, shao, intratumor, liu, shanghai, csv, tumor, jiang, patients, high, human, genomic, research, clinical, access, nat, privacy, cookies, content, publish, zhiming, genome, somatic, myc, cell, mroz, author, information, search, mutantallele, ding, yizhou, xiyu, progression, atlas, mutations,

Topics {āœ’ļø}

pgc-1alpha-responsive genes involved c-myc-induced genomic instability month download article/chapter mutant-allele tumor heterogeneity intra-tumor genetic heterogeneity triple-negative breast cancer intra-tumour heterogeneity zhi-ming shao cancer genome atlas single-cell genetic analysis arm-level scna events intra-tumor heterogeneity machine learning full article pdf breast cancer patients breast cancer 12dz2260100 mootha vk mroz ea human breast tumours primary breast cancer privacy choices/manage cookies promote genomic instability c-myc overexpression african american race related subjects lehmann bd patient informed consent intratumor genetic heterogeneity hormone receptor-positive complex cancer genomics somatic mutation profiles yi-zhou jiang xi-yu liu article ma pan-cancer analysis integrative analysis reveals glioblastoma defines subpopulations article log human cancers intratumoral heterogeneity conserved genomic imbalances shanghai hospitals shdc12010116 shanghai key laboratory shanghai medical college lung cancer breast cancer european economic area reis-filho js activating erbb3 signaling berroa garcia ly

Questions {ā“}

  • Marusyk A, Almendro V, Polyak K (2012) Intra-tumour heterogeneity: a looking glass for cancer?

Schema {šŸ—ŗļø}

WebPage:
      mainEntity:
         headline:Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer
         description:Intra-tumor heterogeneity (ITH) plays a pivotal role in driving breast cancer progression and therapeutic resistance. We used a mutant-allele tumor heterogeneity (MATH) algorithm to measure ITH and explored its correlation with clinical parameters and multi-omics data. We assessed 916 female breast cancer patients from The Cancer Genome Atlas. We calculated the MATH values from whole-exome sequencing data and further investigated their correlation with clinical characteristics, somatic mutations, somatic copy number alterations (SCNAs), and gene enrichment. The patients were divided into low, intermediate, and high MATH groups. High T stage, African American race, and triple-negative or basal-like subtype were associated with a higher MATH level (all PĀ <Ā 0.001). In hormone receptor-positive and human epidermal growth factor receptor-negative patients, the high MATH group showed a tendency toward a worse overall survival (PĀ =Ā 0.052); Furthermore, the TP53 mutation rate increased as MATH was elevated (PĀ <Ā 0.001), whereas CDH1 mutations were correlated with a lower level of MATH (PĀ =Ā 0.002). Several focal and arm-level SCNA events were more common in the high MATH group (PĀ <Ā 0.05), including Chr8q24 with only the MYC gene in the ā€œpeakā€ region. Similarly, high MATH was associated with gene set enrichment related to the MYC pathway and proliferation. Our integrative analysis reveals the clinical and genetic relevance of ITH in breast cancer. These results also suggest the origin and natural history of clonal evolution and intra-tumor genetic heterogeneity, which warrant further investigation.
         datePublished:2017-01-16T00:00:00Z
         dateModified:2017-01-16T00:00:00Z
         pageStart:39
         pageEnd:48
         sameAs:https://doi.org/10.1007/s10549-017-4113-z
         keywords:
            Intra-tumor genetic heterogeneity
            Mutant-allele tumor heterogeneity
            The Cancer Genome Atlas
            Breast cancer
            MYC
            Oncology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10549-017-4113-z/MediaObjects/10549_2017_4113_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10549-017-4113-z/MediaObjects/10549_2017_4113_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10549-017-4113-z/MediaObjects/10549_2017_4113_Fig3_HTML.gif
         isPartOf:
            name:Breast Cancer Research and Treatment
            issn:
               1573-7217
               0167-6806
            volumeNumber:162
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Ding Ma
               affiliation:
                     name:Fudan University Shanghai Cancer Center
                     address:
                        name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Fudan University
                     address:
                        name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yi-Zhou Jiang
               affiliation:
                     name:Fudan University Shanghai Cancer Center
                     address:
                        name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Fudan University
                     address:
                        name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xi-Yu Liu
               affiliation:
                     name:Fudan University Shanghai Cancer Center
                     address:
                        name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Fudan University
                     address:
                        name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yi-Rong Liu
               affiliation:
                     name:Fudan University Shanghai Cancer Center
                     address:
                        name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Fudan University
                     address:
                        name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zhi-Ming Shao
               affiliation:
                     name:Fudan University Shanghai Cancer Center
                     address:
                        name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Fudan University
                     address:
                        name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Fudan University
                     address:
                        name:Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer
      description:Intra-tumor heterogeneity (ITH) plays a pivotal role in driving breast cancer progression and therapeutic resistance. We used a mutant-allele tumor heterogeneity (MATH) algorithm to measure ITH and explored its correlation with clinical parameters and multi-omics data. We assessed 916 female breast cancer patients from The Cancer Genome Atlas. We calculated the MATH values from whole-exome sequencing data and further investigated their correlation with clinical characteristics, somatic mutations, somatic copy number alterations (SCNAs), and gene enrichment. The patients were divided into low, intermediate, and high MATH groups. High T stage, African American race, and triple-negative or basal-like subtype were associated with a higher MATH level (all PĀ <Ā 0.001). In hormone receptor-positive and human epidermal growth factor receptor-negative patients, the high MATH group showed a tendency toward a worse overall survival (PĀ =Ā 0.052); Furthermore, the TP53 mutation rate increased as MATH was elevated (PĀ <Ā 0.001), whereas CDH1 mutations were correlated with a lower level of MATH (PĀ =Ā 0.002). Several focal and arm-level SCNA events were more common in the high MATH group (PĀ <Ā 0.05), including Chr8q24 with only the MYC gene in the ā€œpeakā€ region. Similarly, high MATH was associated with gene set enrichment related to the MYC pathway and proliferation. Our integrative analysis reveals the clinical and genetic relevance of ITH in breast cancer. These results also suggest the origin and natural history of clonal evolution and intra-tumor genetic heterogeneity, which warrant further investigation.
      datePublished:2017-01-16T00:00:00Z
      dateModified:2017-01-16T00:00:00Z
      pageStart:39
      pageEnd:48
      sameAs:https://doi.org/10.1007/s10549-017-4113-z
      keywords:
         Intra-tumor genetic heterogeneity
         Mutant-allele tumor heterogeneity
         The Cancer Genome Atlas
         Breast cancer
         MYC
         Oncology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10549-017-4113-z/MediaObjects/10549_2017_4113_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10549-017-4113-z/MediaObjects/10549_2017_4113_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10549-017-4113-z/MediaObjects/10549_2017_4113_Fig3_HTML.gif
      isPartOf:
         name:Breast Cancer Research and Treatment
         issn:
            1573-7217
            0167-6806
         volumeNumber:162
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ding Ma
            affiliation:
                  name:Fudan University Shanghai Cancer Center
                  address:
                     name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Fudan University
                  address:
                     name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yi-Zhou Jiang
            affiliation:
                  name:Fudan University Shanghai Cancer Center
                  address:
                     name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Fudan University
                  address:
                     name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xi-Yu Liu
            affiliation:
                  name:Fudan University Shanghai Cancer Center
                  address:
                     name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Fudan University
                  address:
                     name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yi-Rong Liu
            affiliation:
                  name:Fudan University Shanghai Cancer Center
                  address:
                     name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Fudan University
                  address:
                     name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zhi-Ming Shao
            affiliation:
                  name:Fudan University Shanghai Cancer Center
                  address:
                     name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Fudan University
                  address:
                     name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Fudan University
                  address:
                     name:Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Breast Cancer Research and Treatment
      issn:
         1573-7217
         0167-6806
      volumeNumber:162
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Fudan University Shanghai Cancer Center
      address:
         name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University
      address:
         name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University Shanghai Cancer Center
      address:
         name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University
      address:
         name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University Shanghai Cancer Center
      address:
         name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University
      address:
         name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University Shanghai Cancer Center
      address:
         name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University
      address:
         name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University Shanghai Cancer Center
      address:
         name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University
      address:
         name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
         type:PostalAddress
      name:Fudan University
      address:
         name:Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ding Ma
      affiliation:
            name:Fudan University Shanghai Cancer Center
            address:
               name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Fudan University
            address:
               name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yi-Zhou Jiang
      affiliation:
            name:Fudan University Shanghai Cancer Center
            address:
               name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Fudan University
            address:
               name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Xi-Yu Liu
      affiliation:
            name:Fudan University Shanghai Cancer Center
            address:
               name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Fudan University
            address:
               name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yi-Rong Liu
      affiliation:
            name:Fudan University Shanghai Cancer Center
            address:
               name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Fudan University
            address:
               name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Zhi-Ming Shao
      affiliation:
            name:Fudan University Shanghai Cancer Center
            address:
               name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Fudan University
            address:
               name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Fudan University
            address:
               name:Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
      name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
      name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
      name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
      name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
      name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
      name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
      name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
      name:Department of Breast Surgery, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of China
      name:Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China
      name:Institutes of Biomedical Sciences, Fudan University, Shanghai, People’s Republic of China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {šŸ”—}(205)

Analytics and Tracking {šŸ“Š}

  • Google Tag Manager

Libraries {šŸ“š}

  • Clipboard.js
  • Prism.js

CDN Services {šŸ“¦}

  • Crossref

5.45s.