We are analyzing https://link.springer.com/article/10.1007/s10522-023-10040-3.

Title:
Dynamics of redox signaling in aging via autophagy, inflammation, and senescence | Biogerontology
Description:
Review paper attempts to explain the dynamic aspects of redox signaling in aging through autophagy, inflammation, and senescence. It begins with ROS source in the cell, then states redox signaling in autophagy, and regulation of autophagy in aging. Next, we discuss inflammation and redox signaling with various pathways involved: NOX pathway, ROS production via TNF-α, IL-1β, xanthine oxidase pathway, COX pathway, and myeloperoxidase pathway. Also, we emphasize oxidative damage as an aging marker and the contribution of pathophysiological factors to aging. In senescence-associated secretory phenotypes, we link ROS with senescence, aging disorders. Relevant crosstalk between autophagy, inflammation, and senescence using a balanced ROS level might reduce age-related disorders. Transducing the context-dependent signal communication among these three processes at high spatiotemporal resolution demands other tools like multi-omics aging biomarkers, artificial intelligence, machine learning, and deep learning. The bewildering advancement of technology in the above areas might progress age-related disorders diagnostics with precision and accuracy.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Telecommunications
Business & Finance

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 8,170,236 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, aging, cell, redox, autophagy, signaling, senescence, oxidative, biol, stress, role, sci, httpsdoiorgs, ageing, human, cells, med, oxygen, reactive, cellular, rev, disease, nat, nature, httpsdoiorg, ros, damage, inflammation, signal, diseases, species, regulation, pathway, myeloperoxidase, senescenceassociated, activation, nox, oxidase, secretory, biomarkers, acad, springer, senescent, free, biochem,

Topics {✒️}

camp-pka-ampk-nf-κb axis ros-activated nf-κb signalling cell surface-bound il-1alpha month download article/chapter sqstm1/p62 activates nfe2l2/nrf2 activation-induced t-cell death thiol-based cell signalling epithelial–mesenchymal transition induced drug-induced cellular senescence ai-driven longevity research context-dependent signal communication double-edged sword revisited pink1/parkin‐mediated mitophagy kavitha thirumurugan ros-generating nadph oxidases reduce age-related disorders full article pdf senescence regulator interleukin-1α il-6/il-8 cytokine network ros-generating oxidases nox1 passos jf age-related nad+ decline mouse cells dependent article biogerontology aims reactive oxygen production nf-κb activation nrf2-p62 autophagy pathway reactive oxygen species superoxide-mediated redox signaling camp/ampk signaling nauseef wm p53 tumor suppressor atayik mc kt formed fig mitochondria-targeted senotherapeutic interventions gp91phox expression induced neutrophil respiratory burst cellular signal transduction ras-dependent signaling privacy choices/manage cookies ros-dependent manner senescence-induced senescence human telomere biology orjalo av pham-huy secreted protein igfbp7 multi-omics aging biomarkers proc biol sci age-dependent decline pearl research park

Questions {❓}

Azzi A (2022) Oxidative stress: what is it?
Birch J, Passos JF (2017) Targeting the SASP to combat ageing: mitochondria as possible intracellular allies?
Emanuele E, Minoretti P, Sanchis-Gomar F et al (2014) Can enhanced autophagy be associated with human longevity?
Kirkwood TBL, Austad SN (2000) Why do we age?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Dynamics of redox signaling in aging via autophagy, inflammation, and senescence
         description:Review paper attempts to explain the dynamic aspects of redox signaling in aging through autophagy, inflammation, and senescence. It begins with ROS source in the cell, then states redox signaling in autophagy, and regulation of autophagy in aging. Next, we discuss inflammation and redox signaling with various pathways involved: NOX pathway, ROS production via TNF-α, IL-1β, xanthine oxidase pathway, COX pathway, and myeloperoxidase pathway. Also, we emphasize oxidative damage as an aging marker and the contribution of pathophysiological factors to aging. In senescence-associated secretory phenotypes, we link ROS with senescence, aging disorders. Relevant crosstalk between autophagy, inflammation, and senescence using a balanced ROS level might reduce age-related disorders. Transducing the context-dependent signal communication among these three processes at high spatiotemporal resolution demands other tools like multi-omics aging biomarkers, artificial intelligence, machine learning, and deep learning. The bewildering advancement of technology in the above areas might progress age-related disorders diagnostics with precision and accuracy.
         datePublished:2023-05-17T00:00:00Z
         dateModified:2023-05-17T00:00:00Z
         pageStart:663
         pageEnd:678
         sameAs:https://doi.org/10.1007/s10522-023-10040-3
         keywords:
            Redox signaling
            Autophagy
            Inflammation
            Senescence
            Aging
            Cell Biology
            Geriatrics/Gerontology
            Developmental Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig6_HTML.png
         isPartOf:
            name:Biogerontology
            issn:
               1573-6768
               1389-5729
            volumeNumber:24
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Netherlands
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Prashanth S. Javali
               affiliation:
                     name:Vellore Institute of Technology
                     address:
                        name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Mouliganesh Sekar
               affiliation:
                     name:Vellore Institute of Technology
                     address:
                        name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ashish Kumar
               affiliation:
                     name:Vellore Institute of Technology
                     address:
                        name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kavitha Thirumurugan
               url:http://orcid.org/0000-0002-4673-4099
               affiliation:
                     name:Vellore Institute of Technology
                     address:
                        name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Dynamics of redox signaling in aging via autophagy, inflammation, and senescence
      description:Review paper attempts to explain the dynamic aspects of redox signaling in aging through autophagy, inflammation, and senescence. It begins with ROS source in the cell, then states redox signaling in autophagy, and regulation of autophagy in aging. Next, we discuss inflammation and redox signaling with various pathways involved: NOX pathway, ROS production via TNF-α, IL-1β, xanthine oxidase pathway, COX pathway, and myeloperoxidase pathway. Also, we emphasize oxidative damage as an aging marker and the contribution of pathophysiological factors to aging. In senescence-associated secretory phenotypes, we link ROS with senescence, aging disorders. Relevant crosstalk between autophagy, inflammation, and senescence using a balanced ROS level might reduce age-related disorders. Transducing the context-dependent signal communication among these three processes at high spatiotemporal resolution demands other tools like multi-omics aging biomarkers, artificial intelligence, machine learning, and deep learning. The bewildering advancement of technology in the above areas might progress age-related disorders diagnostics with precision and accuracy.
      datePublished:2023-05-17T00:00:00Z
      dateModified:2023-05-17T00:00:00Z
      pageStart:663
      pageEnd:678
      sameAs:https://doi.org/10.1007/s10522-023-10040-3
      keywords:
         Redox signaling
         Autophagy
         Inflammation
         Senescence
         Aging
         Cell Biology
         Geriatrics/Gerontology
         Developmental Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10522-023-10040-3/MediaObjects/10522_2023_10040_Fig6_HTML.png
      isPartOf:
         name:Biogerontology
         issn:
            1573-6768
            1389-5729
         volumeNumber:24
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Netherlands
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Prashanth S. Javali
            affiliation:
                  name:Vellore Institute of Technology
                  address:
                     name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Mouliganesh Sekar
            affiliation:
                  name:Vellore Institute of Technology
                  address:
                     name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ashish Kumar
            affiliation:
                  name:Vellore Institute of Technology
                  address:
                     name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kavitha Thirumurugan
            url:http://orcid.org/0000-0002-4673-4099
            affiliation:
                  name:Vellore Institute of Technology
                  address:
                     name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Biogerontology
      issn:
         1573-6768
         1389-5729
      volumeNumber:24
Organization:
      name:Springer Netherlands
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Vellore Institute of Technology
      address:
         name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
         type:PostalAddress
      name:Vellore Institute of Technology
      address:
         name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
         type:PostalAddress
      name:Vellore Institute of Technology
      address:
         name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
         type:PostalAddress
      name:Vellore Institute of Technology
      address:
         name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Prashanth S. Javali
      affiliation:
            name:Vellore Institute of Technology
            address:
               name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
               type:PostalAddress
            type:Organization
      name:Mouliganesh Sekar
      affiliation:
            name:Vellore Institute of Technology
            address:
               name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
               type:PostalAddress
            type:Organization
      name:Ashish Kumar
      affiliation:
            name:Vellore Institute of Technology
            address:
               name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
               type:PostalAddress
            type:Organization
      name:Kavitha Thirumurugan
      url:http://orcid.org/0000-0002-4673-4099
      affiliation:
            name:Vellore Institute of Technology
            address:
               name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
      name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
      name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
      name:#412J, Structural Biology Lab, Pearl Research Park, School of Biosciences & Technology, Vellore Institute of Technology, Vellore, India
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(702)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.8s.

LINK . SPRINGER . COM {}