
NCBI . NLM . NIH . GOV {
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Title[redir]:
Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue - PMC
Description:
Nicotinamide adenine dinucleotide (NAD+) is an essential electron transporter in mitochondrial respiration and oxidative phosphorylation. In genomic DNA, NAD+ also represents the sole substrate for the nuclear repair enzyme, poly(ADP-ribose) ...
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Keywords {🔍}
nad, activity, age, parp, google, scholar, doi, pubmed, sirt, dna, damage, levels, males, line, oxidative, correlation, females, aging, tissue, fig, significant, years, human, lipid, free, peroxidation, subjects, stress, study, cell, increased, pmc, aged, mda, cellular, increase, observed, compared, article, increases, significantly, data, polyadpribose, correlated, decline, studies, generate, assay, distributed, repair,
Topics {✒️}
peroxisome proliferator-activated receptor-γ parametric mann-whitney u-test taking anti-inflammatory medications estrogen/estrogen receptor α hplc-electrochemical detection assay pmc beta search nad-dependent histone deacetylases anti-phospho-h2ax-ser139 shows post-pubescent data post-pubescent data shows cell-cycle phase specific aif-mediated cell death short-term caloric restriction nad-dependent p53 deacetylase post-pubescent female subjects nuclear adp-ribosylation reactions funding statement ng nad+/mg protein time-dependent progressive decline oxidative stress-induced poly free radical source nad+-dependent atp generation student allocated funding mm mda/mg protein nicotinamide adenine dinucleotide calorie-restricted diet parp-mediated nad+ depletion sydney adventist hospital shows post-pubescent sun exposed areas publisher site pdf age-related oxidative stress molecular nick sensor peroxide-induced depletion fu/mg protein improved cycling assay post-pubescent data numerous cellular processes sirt1 deacetylase activity intracellular antioxidant capacity post-pubescent subjects cellular redox reactions reactive oxygen species license information pmcid nuclear repair enzyme silent information regulators promising drug candidates related biochemical entities human skeletal muscle promote cell survival
Questions {❓}
- Hassa P, Haenni S, Elser M, Hottiger M (2006) Nuclear ADP-ribosylation reactions in mammalian cells: Where are we today and where are we going?
- Zhang J (2003) Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked?
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