We are analyzing https://link.springer.com/article/10.1007/s10495-017-1424-9.

Title:
Induction of reactive oxygen species: an emerging approach for cancer therapy | Apoptosis
Description:
Reactive oxygen species (ROS), a group of ions and molecules, include hydroxyl radicals (·OH), alkoxyl radicals, superoxide anion (O2·−), singlet oxygen (1O2) and hydrogen peroxide (H2O2). Hydroxyl radicals and alkoxyl radicals are extremely and highly reactive species respectively. Endogenous ROS are mainly formed in mitochondrial respiratory chain. Low levels of ROS play important roles in regulating biological functions in mammalian cells. However, excess production of ROS can induce cell death by oxidative damaging effects to intracellular biomacromolecules. Cancer cell death types induced by ROS include apoptotic, autophagic, ferroptotic and necrotic cell death. Since abnormal metabolism in cancer cells, they have higher ROS content compared to normal cells. The higher endogenous ROS levels in cancer cells endow them more susceptible to the ROS-induction treatment. Indeed, some anticancer drugs currently used in clinic, such as molecular targeted drugs and chemotherapeutic agents, effectively kill cancer cells by inducing ROS generation. In addition, photodynamic therapy (PDT) is mainly based on induction of ROS burst to kill cancer cells. The mechanism of cell death induced by radiotherapy using ionizing radiation also refers to ROS production. Moreover, ROS play an important role in tumor immune therapy. Altogether, combining above traditional treatments with ROS-induced agents will be considered as a promising strategy in cancer therapy. In this review, we focus on our current understanding of the anticancer effects of ROS.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, google, scholar, article, cas, cancer, cell, cells, central, apoptosis, ros, reactive, oxygen, biol, wang, death, species, therapy, zhang, mitochondrial, pathway, med, oxidative, stress, signaling, autophagy, zou, chen, induces, activation, redox, human, mol, res, yang, free, expression, induction, induced, immunol, production, nat, radic, synergistic, resistance, chem, liu, breast, lung, anticancer,

Topics {✒️}

p-eif2alpha/atf4/chop axis month download article/chapter c-myc-nrf2-keap1 pathway proteasome inhibitor-induced cleavage reactive oxygen species-dependent blocking nf-kappab sensitizes myeloid-derived suppressor cells intestinal p-glycoprotein expression nox-family nadph oxidases ros-mediated mitochondrial pathway nf-kappab/fasl pathway histone deacetylase inhibitor ca2+-coupled mitochondrial processes photofrin-mediated photodynamic therapy p53-ros cross-talk jnk/p38 map kinases her2-positive breast cancer sun yat-sen university fludarabine-resistant cll cells cell receptor-signaling pathways ros-mediated cellular signaling artesunate-induced ferroptosis cell death induced reactive oxygen species c6 glioma cells proline oxidase activates full article pdf endoplasmic reticulum stress induce cell death article apoptosis aims programmed death-1 controls electron transport complex p-glycoprotein expression resveratrol synergistically enhances vdac-dependent permeabilization fas ligand expression highly reactive species ph-triggered chemotherapy metabolic inhibitors accentuate necrotic cell death nonapoptotic cell death immunogenic cell death therapy-resistant state mitochondrial membrane permeabilization mitochondrial calcium handling superoxide induces rapid fas ligand promoter mitochondrial ros production mediated oxidative stress pci-24781 induces caspase

Questions {❓}

Trachootham D, Alexandre J, Huang P (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Induction of reactive oxygen species: an emerging approach for cancer therapy
         description:Reactive oxygen species (ROS), a group of ions and molecules, include hydroxyl radicals (·OH), alkoxyl radicals, superoxide anion (O2·−), singlet oxygen (1O2) and hydrogen peroxide (H2O2). Hydroxyl radicals and alkoxyl radicals are extremely and highly reactive species respectively. Endogenous ROS are mainly formed in mitochondrial respiratory chain. Low levels of ROS play important roles in regulating biological functions in mammalian cells. However, excess production of ROS can induce cell death by oxidative damaging effects to intracellular biomacromolecules. Cancer cell death types induced by ROS include apoptotic, autophagic, ferroptotic and necrotic cell death. Since abnormal metabolism in cancer cells, they have higher ROS content compared to normal cells. The higher endogenous ROS levels in cancer cells endow them more susceptible to the ROS-induction treatment. Indeed, some anticancer drugs currently used in clinic, such as molecular targeted drugs and chemotherapeutic agents, effectively kill cancer cells by inducing ROS generation. In addition, photodynamic therapy (PDT) is mainly based on induction of ROS burst to kill cancer cells. The mechanism of cell death induced by radiotherapy using ionizing radiation also refers to ROS production. Moreover, ROS play an important role in tumor immune therapy. Altogether, combining above traditional treatments with ROS-induced agents will be considered as a promising strategy in cancer therapy. In this review, we focus on our current understanding of the anticancer effects of ROS.
         datePublished:2017-09-21T00:00:00Z
         dateModified:2017-09-21T00:00:00Z
         pageStart:1321
         pageEnd:1335
         sameAs:https://doi.org/10.1007/s10495-017-1424-9
         keywords:
            ROS
            Cancer
            Cell death
            Therapy
            Cancer Research
            Cell Biology
            Oncology
            Biochemistry
            general
            Virology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig6_HTML.gif
         isPartOf:
            name:Apoptosis
            issn:
               1573-675X
               1360-8185
            volumeNumber:22
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Zhengzhi Zou
               affiliation:
                     name:South China Normal University
                     address:
                        name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
                     name:South China Normal University
                     address:
                        name:Joint Laboratory of Laser Oncology with Cancer Center of Sun Yat-sen University, South China Normal University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Haocai Chang
               affiliation:
                     name:South China Normal University
                     address:
                        name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Haolong Li
               affiliation:
                     name:South China Normal University
                     address:
                        name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Songmao Wang
               affiliation:
                     name:South China Normal University
                     address:
                        name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Induction of reactive oxygen species: an emerging approach for cancer therapy
      description:Reactive oxygen species (ROS), a group of ions and molecules, include hydroxyl radicals (·OH), alkoxyl radicals, superoxide anion (O2·−), singlet oxygen (1O2) and hydrogen peroxide (H2O2). Hydroxyl radicals and alkoxyl radicals are extremely and highly reactive species respectively. Endogenous ROS are mainly formed in mitochondrial respiratory chain. Low levels of ROS play important roles in regulating biological functions in mammalian cells. However, excess production of ROS can induce cell death by oxidative damaging effects to intracellular biomacromolecules. Cancer cell death types induced by ROS include apoptotic, autophagic, ferroptotic and necrotic cell death. Since abnormal metabolism in cancer cells, they have higher ROS content compared to normal cells. The higher endogenous ROS levels in cancer cells endow them more susceptible to the ROS-induction treatment. Indeed, some anticancer drugs currently used in clinic, such as molecular targeted drugs and chemotherapeutic agents, effectively kill cancer cells by inducing ROS generation. In addition, photodynamic therapy (PDT) is mainly based on induction of ROS burst to kill cancer cells. The mechanism of cell death induced by radiotherapy using ionizing radiation also refers to ROS production. Moreover, ROS play an important role in tumor immune therapy. Altogether, combining above traditional treatments with ROS-induced agents will be considered as a promising strategy in cancer therapy. In this review, we focus on our current understanding of the anticancer effects of ROS.
      datePublished:2017-09-21T00:00:00Z
      dateModified:2017-09-21T00:00:00Z
      pageStart:1321
      pageEnd:1335
      sameAs:https://doi.org/10.1007/s10495-017-1424-9
      keywords:
         ROS
         Cancer
         Cell death
         Therapy
         Cancer Research
         Cell Biology
         Oncology
         Biochemistry
         general
         Virology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs10495-017-1424-9/MediaObjects/10495_2017_1424_Fig6_HTML.gif
      isPartOf:
         name:Apoptosis
         issn:
            1573-675X
            1360-8185
         volumeNumber:22
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Zhengzhi Zou
            affiliation:
                  name:South China Normal University
                  address:
                     name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
                  name:South China Normal University
                  address:
                     name:Joint Laboratory of Laser Oncology with Cancer Center of Sun Yat-sen University, South China Normal University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Haocai Chang
            affiliation:
                  name:South China Normal University
                  address:
                     name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Haolong Li
            affiliation:
                  name:South China Normal University
                  address:
                     name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Songmao Wang
            affiliation:
                  name:South China Normal University
                  address:
                     name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Apoptosis
      issn:
         1573-675X
         1360-8185
      volumeNumber:22
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:South China Normal University
      address:
         name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
         type:PostalAddress
      name:South China Normal University
      address:
         name:Joint Laboratory of Laser Oncology with Cancer Center of Sun Yat-sen University, South China Normal University, Guangzhou, China
         type:PostalAddress
      name:South China Normal University
      address:
         name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
         type:PostalAddress
      name:South China Normal University
      address:
         name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
         type:PostalAddress
      name:South China Normal University
      address:
         name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Zhengzhi Zou
      affiliation:
            name:South China Normal University
            address:
               name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
               type:PostalAddress
            type:Organization
            name:South China Normal University
            address:
               name:Joint Laboratory of Laser Oncology with Cancer Center of Sun Yat-sen University, South China Normal University, Guangzhou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Haocai Chang
      affiliation:
            name:South China Normal University
            address:
               name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Haolong Li
      affiliation:
            name:South China Normal University
            address:
               name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
               type:PostalAddress
            type:Organization
      name:Songmao Wang
      affiliation:
            name:South China Normal University
            address:
               name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
               type:PostalAddress
            type:Organization
PostalAddress:
      name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
      name:Joint Laboratory of Laser Oncology with Cancer Center of Sun Yat-sen University, South China Normal University, Guangzhou, China
      name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
      name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
      name:MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(444)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.04s.

LINK . SPRINGER . COM {}