We are analyzing https://link.springer.com/article/10.1007/s00248-019-01317-7.

Title:
Effect of the Nursing Mother on the Gut Microbiome of the Offspring During Early Mouse Development | Microbial Ecology
Description:
The development of the gut microbiome is influenced by several factors. It is acquired during and after birth and involves both maternal and environmental factors as well as the genetic disposition of the offspring. However, it is unclear if the microbiome development is directly triggered by the mode of delivery and very early contact with the mother or mostly at later stages of initial development mainly by breast milk provided by the mother. To investigate to what extent the gut microbiome composition of the offspring is determined by the nursing mother, providing breast milk, compared to the birth mother during early development, a cross-fostering experiment involving two genetically different mouse lines was developed, being prone to be obese or lean, respectively. The microbiome of the colon was analyzed by high-throughput 16S rRNA gene sequencing, when the mice were 3 weeks old. The nursing mother affected both α- and β-diversity of the offspring’s gut microbiome and shaped its composition. Especially bacterial families directly transferred by breast milk, like Streptococcaceae, or families which are strongly influenced by the quality of the breast milk like Rikenellaceae, showed a strong response. The core microbiome transferred from the obese nursing mother showed a higher robustness in comparison to the microbiome transferred from the lean nursing mother. Overall, the nursing mother impacts the gut microbial composition of the offspring during early development and might play an important role for health and disease of the animals at later stages of life.
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, google, scholar, cas, gut, microbiome, central, mother, microbial, nursing, microbiota, human, development, nature, knight, milk, ley, early, mouse, host, mice, access, gordon, obesity, content, data, ecology, birth, lean, turnbaugh, privacy, cookies, analysis, research, search, offspring, maternal, composition, obese, genetics, httpsdoiorgnature, lozupone, httpsdoiorgs, genome, bioinformatics, publish, breast, rrna, sequencing,

Topics {✒️}

/ijo/journal/v36/n6/suppinfo/ijo2011153s1 /nmeth/journal/v7/n5/suppinfo/nmeth /nbt/journal/v33/n10/abs/nbt /nature/journal/v444/n7122/suppinfo/nature05414_s1 /nature/journal/v486/n7402/abs/nature11053 /nature/journal/v444/n7122/suppinfo/4441022a_s1 /nature/journal/v535/n7612/abs/nature18646 month download article/chapter cross-fostering experiment involving cross-fostering immediately command-line power tool dominguez-bello mg dietary fiber-induced improvement marker-gene data analysis caporaso jg full article pdf long-term divergent selection gut-related microbes goodrich jk nursing mother affected nursing mother impacts article treichel privacy choices/manage cookies microbial profiling based murine gut microbiota human gut microbes human gut microbiota lean nursing mother maternal microbial communities fat mouse lines comparing microbial communities mouse gut metagenome permanent microbiota shift gut microbial composition related subjects diet-induced obesity early mouse development human milk microbiota r79–r79 murine intestinal microbiota microbial ecology human genetics shape bioinformatics pipeline based article log core gut microbiome birth mother check access instant access infant gut microbiome core microbiome transferred

Questions {❓}

Perez PF, Doré J, Leclerc M, Levenez F, Benyacoub J, Serrant P, Segura-Roggero I, Schiffrin EJ, Donnet-Hughes A (2007) Bacterial imprinting of the neonatal immune system: lessons from maternal cells?

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         Geoecology/Natural Processes
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