
LINK . SPRINGER . COM {
}
Title:
Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice | Diabetologia
Description:
Aims/hypothesis We assessed the contribution of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) signalling to thermogenesis induced by high-fat diet (HFD) consumption. Furthermore, we determined whether brown adipose tissue (BAT) activity contributes to weight loss induced by chronic subcutaneous treatment with the GLP-1R agonist, liraglutide, in a model of diet-induced obesity. Methods Metabolic phenotyping was performed using indirect calorimetry in wild-type (WT) and Glp1r-knockout (KO) mice during chow and HFD feeding at room temperature and at thermoneutrality. In a separate study, we investigated the contribution of BAT thermogenic capacity to the weight lowering effect induced by GLP-1 mimetics by administering liraglutide (10 or 30 nmol kg−1 day−1 s.c.) to diet-induced obese (DIO) mice for 6 or 4 weeks, respectively. In both studies, animals were subjected to a noradrenaline (norepinephrine)-stimulated oxygen consumption V ⋅ O 2 $$ \left(\overset{\cdot }{V}{\mathrm{O}}_2\right) $$ test. Results At thermoneutrality, HFD-fed Glp1r-KO mice had similar energy expenditure (EE) compared with HFD-fed WT controls. However, HFD-fed Glp1r-KO mice exhibited relatively less EE when housed at a cooler standard room temperature, and had relatively lower V ⋅ O 2 $$ \overset{\cdot }{V}{\mathrm{O}}_2 $$ in response to a noradrenaline challenge, which is consistent with impaired BAT thermogenic capacity. In contrast to the loss of function model, chronic peripheral liraglutide treatment did not increase BAT activity as determined by noradrenaline-stimulated V ⋅ O 2 $$ \overset{\cdot }{V}{\mathrm{O}}_2 $$ and BAT gene expression. Conclusions/interpretation These data suggest that although endogenous GLP-1R signalling contributes to increased BAT thermogenesis, this mechanism does not play a significant role in the food intake-independent body weight lowering effect of the GLP-1 mimetic liraglutide in DIO mice.
Website Age:
28 years and 1 months (reg. 1997-05-29).
Matching Content Categories {📚}
- Health & Fitness
- Pets
- Science
Content Management System {📝}
What CMS is link.springer.com built with?
Custom-built
No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of link.springer.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 7,626,182 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Link.springer.com Make Money? {💸}
We can't see how the site brings in money.
Websites don't always need to be profitable; some serve as platforms for education or personal expression. Websites can serve multiple purposes. And this might be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.
Keywords {🔍}
mice, bat, oversetcdot, vmathrmo, liraglutide, pubmed, article, glpr, fig, thermogenesis, nmol, glprko, activity, google, scholar, animals, compared, significantly, energy, cas, signalling, lower, day, hfdfed, vehiclepf, glp, bars, data, adipose, tissue, brown, treatment, similar, food, loss, central, intake, weight, noradrenaline, obesity, hfd, temperature, expression, anova, contribution, effect, gene, role, white, control,
Topics {✒️}
central glp-1r signalling hfd-fed glp1r-ko mice cd-fed glp1r-ko animals full size image endogenous glp-1r signalling glp-1r signalling plays 30 nmol kg−1 day−1 liraglutide-treated diego perez-tilve glp-1r-mediated activation 30 nmol kg−1 day−1 reduced feeding vehicle-treated pair-fed group 10 nmol kg−1 day−1 liraglutide study glp1r-ko mice preserved abolishes diet-induced thermogenesis glp1r-ko mice fed hfd-fed glp1r-ko glp1r-ko hfd-fed food intake-independent reduction gene-specific taqman assays glp-1/glp-1r signaling male c57bl/6j mice lean chow-fed mice central nervous system glp1r-ko mice compared chow-fed conditions remains age-matched wild-type brown adipose tissue brown adipose tissue glp1r-ko mice maintained 30 nmol kg−1 day−1 study 30 nmol kg−1 day−1 liraglutide vehicle-pair-fed mice high-fat diet glp-1r agonist glp-1rs increases endogenous glp-1r recent evidence revealing mice article published vehicle-pf treated mice liraglutide-treated mice compared 30 nmol kg−1 liraglutide study hfd-fed wt controls hfd-fed wt compared high-sucrose diet glp-1 receptor signalling kmh receives funding glp-1r signalling weight lowering effect privacy choices/manage cookies bw lowering effects
Questions {❓}
- Tong J, Sandoval DA (2011) Is the GLP-1 system a viable therapeutic target for weight reduction?
Schema {🗺️}
WebPage:
mainEntity:
headline:Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice
description:We assessed the contribution of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) signalling to thermogenesis induced by high-fat diet (HFD) consumption. Furthermore, we determined whether brown adipose tissue (BAT) activity contributes to weight loss induced by chronic subcutaneous treatment with the GLP-1R agonist, liraglutide, in a model of diet-induced obesity. Metabolic phenotyping was performed using indirect calorimetry in wild-type (WT) and Glp1r-knockout (KO) mice during chow and HFD feeding at room temperature and at thermoneutrality. In a separate study, we investigated the contribution of BAT thermogenic capacity to the weight lowering effect induced by GLP-1 mimetics by administering liraglutide (10 or 30 nmol kg−1 day−1 s.c.) to diet-induced obese (DIO) mice for 6 or 4 weeks, respectively. In both studies, animals were subjected to a noradrenaline (norepinephrine)-stimulated oxygen consumption
$$ \left(\overset{\cdot }{V}{\mathrm{O}}_2\right) $$
test. At thermoneutrality, HFD-fed Glp1r-KO mice had similar energy expenditure (EE) compared with HFD-fed WT controls. However, HFD-fed Glp1r-KO mice exhibited relatively less EE when housed at a cooler standard room temperature, and had relatively lower
$$ \overset{\cdot }{V}{\mathrm{O}}_2 $$
in response to a noradrenaline challenge, which is consistent with impaired BAT thermogenic capacity. In contrast to the loss of function model, chronic peripheral liraglutide treatment did not increase BAT activity as determined by noradrenaline-stimulated
$$ \overset{\cdot }{V}{\mathrm{O}}_2 $$
and BAT gene expression. These data suggest that although endogenous GLP-1R signalling contributes to increased BAT thermogenesis, this mechanism does not play a significant role in the food intake-independent body weight lowering effect of the GLP-1 mimetic liraglutide in DIO mice.
datePublished:2015-06-07T00:00:00Z
dateModified:2015-06-07T00:00:00Z
pageStart:2124
pageEnd:2132
sameAs:https://doi.org/10.1007/s00125-015-3651-3
keywords:
Brown adipose tissue
Diet-induced thermogenesis
GLP-1
High-fat diet
Liraglutide
Internal Medicine
Metabolic Diseases
Human Physiology
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig5_HTML.gif
isPartOf:
name:Diabetologia
issn:
1432-0428
0012-186X
volumeNumber:58
type:
Periodical
PublicationVolume
publisher:
name:Springer Berlin Heidelberg
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Kristy M. Heppner
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Oregon Health and Science University
address:
name:Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, USA
type:PostalAddress
type:Organization
type:Person
name:Sarah Marks
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:Jenna Holland
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:Nickki Ottaway
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:David Smiley
affiliation:
name:Indiana University
address:
name:Department of Chemistry, Indiana University, Bloomington, USA
type:PostalAddress
type:Organization
type:Person
name:Richard Dimarchi
affiliation:
name:Indiana University
address:
name:Department of Chemistry, Indiana University, Bloomington, USA
type:PostalAddress
type:Organization
type:Person
name:Diego Perez-Tilve
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice
description:We assessed the contribution of glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) signalling to thermogenesis induced by high-fat diet (HFD) consumption. Furthermore, we determined whether brown adipose tissue (BAT) activity contributes to weight loss induced by chronic subcutaneous treatment with the GLP-1R agonist, liraglutide, in a model of diet-induced obesity. Metabolic phenotyping was performed using indirect calorimetry in wild-type (WT) and Glp1r-knockout (KO) mice during chow and HFD feeding at room temperature and at thermoneutrality. In a separate study, we investigated the contribution of BAT thermogenic capacity to the weight lowering effect induced by GLP-1 mimetics by administering liraglutide (10 or 30 nmol kg−1 day−1 s.c.) to diet-induced obese (DIO) mice for 6 or 4 weeks, respectively. In both studies, animals were subjected to a noradrenaline (norepinephrine)-stimulated oxygen consumption
$$ \left(\overset{\cdot }{V}{\mathrm{O}}_2\right) $$
test. At thermoneutrality, HFD-fed Glp1r-KO mice had similar energy expenditure (EE) compared with HFD-fed WT controls. However, HFD-fed Glp1r-KO mice exhibited relatively less EE when housed at a cooler standard room temperature, and had relatively lower
$$ \overset{\cdot }{V}{\mathrm{O}}_2 $$
in response to a noradrenaline challenge, which is consistent with impaired BAT thermogenic capacity. In contrast to the loss of function model, chronic peripheral liraglutide treatment did not increase BAT activity as determined by noradrenaline-stimulated
$$ \overset{\cdot }{V}{\mathrm{O}}_2 $$
and BAT gene expression. These data suggest that although endogenous GLP-1R signalling contributes to increased BAT thermogenesis, this mechanism does not play a significant role in the food intake-independent body weight lowering effect of the GLP-1 mimetic liraglutide in DIO mice.
datePublished:2015-06-07T00:00:00Z
dateModified:2015-06-07T00:00:00Z
pageStart:2124
pageEnd:2132
sameAs:https://doi.org/10.1007/s00125-015-3651-3
keywords:
Brown adipose tissue
Diet-induced thermogenesis
GLP-1
High-fat diet
Liraglutide
Internal Medicine
Metabolic Diseases
Human Physiology
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig1_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig3_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig4_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00125-015-3651-3/MediaObjects/125_2015_3651_Fig5_HTML.gif
isPartOf:
name:Diabetologia
issn:
1432-0428
0012-186X
volumeNumber:58
type:
Periodical
PublicationVolume
publisher:
name:Springer Berlin Heidelberg
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Kristy M. Heppner
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Oregon Health and Science University
address:
name:Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, USA
type:PostalAddress
type:Organization
type:Person
name:Sarah Marks
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:Jenna Holland
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:Nickki Ottaway
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
type:Person
name:David Smiley
affiliation:
name:Indiana University
address:
name:Department of Chemistry, Indiana University, Bloomington, USA
type:PostalAddress
type:Organization
type:Person
name:Richard Dimarchi
affiliation:
name:Indiana University
address:
name:Department of Chemistry, Indiana University, Bloomington, USA
type:PostalAddress
type:Organization
type:Person
name:Diego Perez-Tilve
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Diabetologia
issn:
1432-0428
0012-186X
volumeNumber:58
Organization:
name:Springer Berlin Heidelberg
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
name:Oregon Health and Science University
address:
name:Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, USA
type:PostalAddress
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
name:Indiana University
address:
name:Department of Chemistry, Indiana University, Bloomington, USA
type:PostalAddress
name:Indiana University
address:
name:Department of Chemistry, Indiana University, Bloomington, USA
type:PostalAddress
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Kristy M. Heppner
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Oregon Health and Science University
address:
name:Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, USA
type:PostalAddress
type:Organization
name:Sarah Marks
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Jenna Holland
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:Nickki Ottaway
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
name:David Smiley
affiliation:
name:Indiana University
address:
name:Department of Chemistry, Indiana University, Bloomington, USA
type:PostalAddress
type:Organization
name:Richard Dimarchi
affiliation:
name:Indiana University
address:
name:Department of Chemistry, Indiana University, Bloomington, USA
type:PostalAddress
type:Organization
name:Diego Perez-Tilve
affiliation:
name:University of Cincinnati
address:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
name:Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, USA
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
name:Department of Chemistry, Indiana University, Bloomington, USA
name:Department of Chemistry, Indiana University, Bloomington, USA
name:Metabolic Diseases Institute, Department of Medicine/Internal Medicine, University of Cincinnati, Cincinnati, USA
External Links {🔗}(136)
- Profit of https://www.springernature.com/gp/authors
- What are the earnings of https://link.springernature.com/home/?
- How much does https://order.springer.com/public/cart make?
- https://mc.manuscriptcentral.com/diabetologia's revenue stream
- What's the income of https://beta.springernature.com/pre-submission?journalId=125?
- What are the total earnings of https://doi.org/10.1089%2Fdia.2012.0098.edw?
- How much profit is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22845681 making per month?
- What's http://scholar.google.com/scholar_lookup?&title=An%20update%20in%20incretin-based%20therapy%3A%20a%20focus%20on%20glucagon-like%20peptide-1%20receptor%20agonists&journal=Diabetes%20Technol%20Ther&doi=10.1089%2Fdia.2012.0098.edw&volume=14&pages=951-967&publication_year=2012&author=Edwards%2CKL&author=Stapleton%2CM&author=Weis%2CJ&author=Irons%2CBK's gross income?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145813 generate monthly?
- How much cash flow does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21336840 have monthly?
- Profit of http://scholar.google.com/scholar_lookup?&title=Is%20the%20GLP-1%20system%20a%20viable%20therapeutic%20target%20for%20weight%20reduction%3F&journal=Rev%20Endocr%20Metab%20Disord&doi=10.1007%2Fs11154-011-9170-8&volume=12&pages=187-195&publication_year=2011&author=Tong%2CJ&author=Sandoval%2CDA
- How much profit does https://doi.org/10.2337%2Fdb11-1556 make?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478556 make?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22933116 produce monthly?
- Learn how profitable http://scholar.google.com/scholar_lookup?&title=Direct%20control%20of%20brown%20adipose%20tissue%20thermogenesis%20by%20central%20nervous%20system%20glucagon-like%20peptide-1%20receptor%20signaling&journal=Diabetes&doi=10.2337%2Fdb11-1556&volume=61&pages=2753-2762&publication_year=2012&author=Lockie%2CSH&author=Heppner%2CKM&author=Chaudhary%2CN is on a monthly basis
- How much money does https://doi.org/10.2337%2Fdb14-0302 make?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24917578 generate monthly?
- How much money does http://scholar.google.com/scholar_lookup?&title=GLP-1%20agonism%20stimulates%20brown%20adipose%20tissue%20thermogenesis%20and%20browning%20through%20hypothalamic%20AMPK&journal=Diabetes&doi=10.2337%2Fdb14-0302&volume=63&pages=3346-3358&publication_year=2014&author=Beiroa%2CD&author=Imbernon%2CM&author=Gallego%2CR generate?
- Get to know what's the income of https://doi.org/10.4161%2Fadip.25417
- http://scholar.google.com/scholar_lookup?&title=Brown%20adipose%20tissue%20thermogenesis%20in%20the%20resistance%20to%20and%20reversal%20of%20obesity%3A%20a%20potential%20new%20mechanism%20contributing%20to%20the%20metabolic%20benefits%20of%20proglucagon-derived%20peptides&journal=Adipocytes&doi=10.4161%2Fadip.25417&volume=2&pages=196-200&publication_year=2013&author=Lockie%2CSH&author=Stefanidis%2CA&author=Oldfield%2CBJ&author=Perez-Tilve%2CD income
- What are the earnings of https://doi.org/10.1038%2F366740a0?
- Discover the revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8264795
- How much does http://scholar.google.com/scholar_lookup?&title=Development%20of%20obesity%20in%20transgenic%20mice%20after%20genetic%20ablation%20of%20brown%20adipose%20tissue&journal=Nature&doi=10.1038%2F366740a0&volume=366&pages=740-742&publication_year=1993&author=Lowell%2CBB&author=S-Susulic%2CV&author=Hamann%2CA bring in each month?
- Revenue of https://doi.org/10.1016%2Fj.cmet.2008.12.014
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19187776 produce monthly?
- Get to know http://scholar.google.com/scholar_lookup?&title=UCP1%20ablation%20induces%20obesity%20and%20abolishes%20diet-induced%20thermogenesis%20in%20mice%20exempt%20from%20thermal%20stress%20by%20living%20at%20thermoneutrality&journal=Cell%20Metab&doi=10.1016%2Fj.cmet.2008.12.014&volume=9&pages=203-209&publication_year=2009&author=Feldmann%2CHM&author=Golozoubova%2CV&author=Cannon%2CB&author=Nedergaard%2CJ's earnings
- What's the financial gain of https://doi.org/10.1126%2Fscience.1074923?
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12161638 make?
- Earnings of http://scholar.google.com/scholar_lookup?&title=Biomedicine.%20A%20sympathetic%20defense%20against%20obesity&journal=Science&doi=10.1126%2Fscience.1074923&volume=297&pages=780-781&publication_year=2002&author=Dulloo%2CAG
- Learn how profitable http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10766252 is on a monthly basis
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Towards%20a%20molecular%20understanding%20of%20adaptive%20thermogenesis&journal=Nature&volume=404&pages=652-660&publication_year=2000&author=Lowell%2CBB&author=Spiegelman%2CBM?
- How much cash flow does https://doi.org/10.1126%2Fscience.1073160 have monthly?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12161655 rake in every month?
- http://scholar.google.com/scholar_lookup?&title=betaAR%20signaling%20required%20for%20diet-induced%20thermogenesis%20and%20obesity%20resistance&journal=Science&doi=10.1126%2Fscience.1073160&volume=297&pages=843-845&publication_year=2002&author=Bachman%2CES&author=Dhillon%2CH&author=Zhang%2CCY's financial summary
- Profit of https://doi.org/10.1038%2F281031a0
- Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=551265
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=A%20role%20for%20brown%20adipose%20tissue%20in%20diet-induced%20thermogenesis&journal=Nature&doi=10.1038%2F281031a0&volume=281&pages=31-35&publication_year=1979&author=Rothwell%2CNJ&author=Stock%2CMJ?
- How much money does https://doi.org/10.1056%2FNEJMoa0808949 generate?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19357407 income
- How profitable is http://scholar.google.com/scholar_lookup?&title=Functional%20brown%20adipose%20tissue%20in%20healthy%20adults&journal=N%20Engl%20J%20Med&doi=10.1056%2FNEJMoa0808949&volume=360&pages=1518-1525&publication_year=2009&author=Virtanen%2CKA&author=Lidell%2CME&author=Orava%2CJ?
- How much does https://doi.org/10.1056%2FNEJMoa0810780 net monthly?
- How much cash flow does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859951 have monthly?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19357406 income
- What's http://scholar.google.com/scholar_lookup?&title=Identification%20and%20importance%20of%20brown%20adipose%20tissue%20in%20adult%20humans&journal=N%20Engl%20J%20Med&doi=10.1056%2FNEJMoa0810780&volume=360&pages=1509-1517&publication_year=2009&author=Cypess%2CAM&author=Lehman%2CS&author=Williams%2CG's gross income?
- What are the total earnings of https://doi.org/10.1056%2FNEJMoa0808718?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19357405 make?
- How much does http://scholar.google.com/scholar_lookup?&title=Cold-activated%20brown%20adipose%20tissue%20in%20healthy%20men&journal=N%20Engl%20J%20Med&doi=10.1056%2FNEJMoa0808718&volume=360&pages=1500-1508&publication_year=2009&author=Marken%20Lichtenbelt%2CWD&author=Vanhommerig%2CJW&author=Smulders%2CNM bring in each month?
- How much profit is https://doi.org/10.1056%2FNEJMe0900466 making per month?
- What's the revenue for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753374?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19357412 produce monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Brown%20adipose%20tissue%E2%80%93when%20it%20pays%20to%20be%20inefficient&journal=N%20Engl%20J%20Med&doi=10.1056%2FNEJMe0900466&volume=360&pages=1553-1556&publication_year=2009&author=Celi%2CFS rake in every month?
- How much does https://doi.org/10.1038%2Fnm1196-1254 gross monthly?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8898756 make?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Glucose%20intolerance%20but%20normal%20satiety%20in%20mice%20with%20a%20null%20mutation%20in%20the%20glucagon-like%20peptide%201%20receptor%20gene&journal=Nat%20Med&doi=10.1038%2Fnm1196-1254&volume=2&pages=1254-1258&publication_year=1996&author=Scrocchi%2CLA&author=Brown%2CTJ&author=MaClusky%2CN
- Financial intake of https://doi.org/10.1038%2Foby.2004.20
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14742854's financial summary
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Evaluation%20of%20a%20quantitative%20magnetic%20resonance%20method%20for%20mouse%20whole%20body%20composition%20analysis&journal=Obes%20Res&doi=10.1038%2Foby.2004.20&volume=12&pages=150-160&publication_year=2004&author=Tinsley%2CFC&author=Taicher%2CGZ&author=Heiman%2CML bring in?
- What's the financial intake of https://doi.org/10.1038%2Fnchembio.209?
- Explore the financials of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19597507
- How much income does http://scholar.google.com/scholar_lookup?&title=A%20new%20glucagon%20and%20GLP-1%20co-agonist%20eliminates%20obesity%20in%20rodents&journal=Nat%20Chem%20Biol&doi=10.1038%2Fnchembio.209&volume=5&pages=749-757&publication_year=2009&author=Day%2CJW&author=Ottaway%2CN&author=Patterson%2CJT have?
- How much does https://doi.org/10.1242%2Fjeb.050989 make?
- How profitable is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21177944?
- How much profit is http://scholar.google.com/scholar_lookup?&title=Nonshivering%20thermogenesis%20and%20its%20adequate%20measurement%20in%20metabolic%20studies&journal=J%20Exp%20Biol&doi=10.1242%2Fjeb.050989&volume=214&pages=242-253&publication_year=2011&author=Cannon%2CB&author=Nedergaard%2CJ making per month?
- What's the profit of https://doi.org/10.1172%2FJCI25483?
- Get to know what's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1705821
- What's the financial intake of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17187081?
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Extrapancreatic%20incretin%20receptors%20modulate%20glucose%20homeostasis%2C%20body%20weight%2C%20and%20energy%20expenditure&journal=J%20Clin%20Invest&doi=10.1172%2FJCI25483&volume=117&pages=143-152&publication_year=2007&author=Hansotia%2CT&author=Maida%2CA&author=Flock%2CG?
- What are the earnings of https://doi.org/10.2337%2Fdb12-1498?
- Earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712071
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23434938 rake in every month?
- http://scholar.google.com/scholar_lookup?&title=Vertical%20sleeve%20gastrectomy%20is%20effective%20in%20two%20genetic%20mouse%20models%20of%20glucagon-like%20peptide%201%20receptor%20deficiency&journal=Diabetes&doi=10.2337%2Fdb12-1498&volume=62&pages=2380-2385&publication_year=2013&author=Wilson-Perez%2CHE&author=Chambers%2CAP&author=Ryan%2CKK's total income per month
- How much money does https://doi.org/10.1152%2Fphysrev.00015.2003 make?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14715917's total income per month
- How much does http://scholar.google.com/scholar_lookup?&title=Brown%20adipose%20tissue%3A%20function%20and%20physiological%20significance&journal=Physiol%20Rev&doi=10.1152%2Fphysrev.00015.2003&volume=84&pages=277-359&publication_year=2004&author=Cannon%2CB&author=Nedergaard%2CJ pull in monthly?
- How much profit does https://doi.org/10.1210%2Fen.2008-0180 make?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18556349 generate monthly?
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Brain%20glucagon-like%20peptide%201%20signaling%20controls%20the%20onset%20of%20high-fat%20diet-induced%20insulin%20resistance%20and%20reduces%20energy%20expenditure&journal=Endocrinology&doi=10.1210%2Fen.2008-0180&volume=149&pages=4768-4777&publication_year=2008&author=Knauf%2CC&author=Cani%2CPD&author=Ait-Belgnaoui%2CA?
- What's the monthly income of https://doi.org/10.1523%2FJNEUROSCI.2212-10.2011?
- What's the monthly income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700400?
- Monthly income for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21389245
- How much does http://scholar.google.com/scholar_lookup?&title=Hyperphagia%20and%20increased%20fat%20accumulation%20in%20two%20models%20of%20chronic%20CNS%20glucagon-like%20peptide-1%20loss%20of%20function&journal=J%20Neurosci&doi=10.1523%2FJNEUROSCI.2212-10.2011&volume=31&pages=3904-3913&publication_year=2011&author=Barrera%2CJG&author=Jones%2CKR&author=Herman%2CJP&author=D%27Alessio%2CDA&author=Woods%2CSC&author=Seeley%2CRJ pull in monthly?
- Financial intake of https://doi.org/10.1074%2Fjbc.M111.310342
- How much money does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307265 make?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22207759 pull in?
- http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20adipocyte%20formation%20by%20GLP-1%2FGLP-1R%20signaling&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M111.310342&volume=287&pages=6421-6430&publication_year=2012&author=Challa%2CTD&author=Beaton%2CN&author=Arnold%2CM&author=Rudofsky%2CG&author=Langhans%2CW&author=Wolfrum%2CC's total income per month
- How much does https://doi.org/10.1172%2FJCI43615 pull in monthly?
- Get to know what's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083792
- Learn how profitable http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21540554 is on a monthly basis
- How much does http://scholar.google.com/scholar_lookup?&title=Dual%20elimination%20of%20the%20glucagon%20and%20GLP-1%20receptors%20in%20mice%20reveals%20plasticity%20in%20the%20incretin%20axis&journal=J%20Clin%20Invest&doi=10.1172%2FJCI43615&volume=121&pages=1917-1929&publication_year=2011&author=Ali%2CS&author=Lamont%2CBJ&author=Charron%2CMJ&author=Drucker%2CDJ bring in each month?
- Learn about the earnings of https://doi.org/10.1073%2Fpnas.0631828100
- What's the financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164531?
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12748388
- http://scholar.google.com/scholar_lookup?&title=Mice%20lacking%20dipeptidyl%20peptidase%20IV%20are%20protected%20against%20obesity%20and%20insulin%20resistance&journal=Proc%20Natl%20Acad%20Sci%20U%20S%20A&doi=10.1073%2Fpnas.0631828100&volume=100&pages=6825-6830&publication_year=2003&author=Conarello%2CSL&author=Li%2CZ&author=Ronan%2CJ's financial summary
- Discover the revenue of https://doi.org/10.1172%2FJCI75276
- How much revenue does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215190 generate?
- What's the financial outcome of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25202980?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=The%20arcuate%20nucleus%20mediates%20GLP-1%20receptor%20agonist%20liraglutide-dependent%20weight%20loss&journal=J%20Clin%20Invest&doi=10.1172%2FJCI75276&volume=124&pages=4473-4488&publication_year=2014&author=Secher%2CA&author=Jelsing%2CJ&author=Baquero%2CAF?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12110661's financial summary
- How much does http://scholar.google.com/scholar_lookup?&title=UCP2%20and%20UCP3%20in%20muscle%20controlling%20body%20metabolism&journal=J%20Exp%20Biol&volume=205&pages=2275-2285&publication_year=2002&author=Schrauwen%2CP&author=Hesselink%2CM gross monthly?
- Profit of https://doi.org/10.1006%2Fbbrc.1999.0239
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10066417 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=Genomic%20organization%20and%20regulation%20by%20dietary%20fat%20of%20the%20uncoupling%20protein%203%20and%202%20genes&journal=Biochem%20Biophys%20Res%20Commun&doi=10.1006%2Fbbrc.1999.0239&volume=256&pages=27-32&publication_year=1999&author=Gong%2CDW&author=He%2CY&author=Reitman%2CML generate monthly?
- How much does https://citation-needed.springer.com/v2/references/10.1007/s00125-015-3651-3?format=refman&flavour=references net monthly?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kristy%20M.%20Heppner rake in every month?
- How much money does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kristy%20M.%20Heppner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- Learn about the earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Sarah%20Marks
- Learn about the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Sarah%20Marks%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jenna%20Holland net monthly?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jenna%20Holland%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's revenue stream
- How much profit is https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Nickki%20Ottaway making per month?
- How much income does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Nickki%20Ottaway%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have?
- What's the income generated by https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=David%20Smiley each month?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22David%20Smiley%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's total income per month
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Richard%20Dimarchi generate?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Richard%20Dimarchi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en rake in every month?
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Diego%20Perez-Tilve generate?
- Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Diego%20Perez-Tilve%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- https://s100.copyright.com/AppDispatchServlet?title=Contribution%20of%20brown%20adipose%20tissue%20activity%20to%20the%20control%20of%20energy%20balance%20by%20GLP-1%20receptor%20signalling%20in%20mice&author=Kristy%20M.%20Heppner%20et%20al&contentID=10.1007%2Fs00125-015-3651-3©right=Springer-Verlag%20Berlin%20Heidelberg&publication=0012-186X&publicationDate=2015-06-07&publisherName=SpringerNature&orderBeanReset=true's revenue stream
- Learn about the earnings of https://crossmark.crossref.org/dialog/?doi=10.1007/s00125-015-3651-3
- Get to know what's the income of https://citation-needed.springer.com/v2/references/10.1007/s00125-015-3651-3?format=refman&flavour=citation
- https://authorservices.springernature.com/go/sn/?utm_source=SNLinkfooter&utm_medium=Web&utm_campaign=SNReferral income
- How much revenue does https://www.springernature.com/gp/open-research/about/the-fundamentals-of-open-access-and-open-research produce monthly?
- How much does https://www.springernature.com/gp/products earn?
- https://www.springernature.com/gp/librarians's total income per month
- Earnings of https://www.springernature.com/gp/societies
- https://www.springernature.com/gp/partners's revenue stream
- What's the revenue for https://www.springer.com/?
- Financial intake of https://www.nature.com/
- How much revenue does https://www.biomedcentral.com/ bring in?
- What are the earnings of https://www.palgrave.com/?
- Explore the financials of https://www.apress.com/
- See how much https://www.springernature.com/gp/legal/ccpa makes per month
- How much does https://www.springernature.com/gp/info/accessibility bring in each month?
- How much revenue does https://support.springernature.com/en/support/home produce monthly?
- How much revenue does https://support.springernature.com/en/support/solutions/articles/6000255911-subscription-cancellations generate?
- What's the monthly income of https://www.springernature.com/?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Clipboard.js
- Prism.js
CDN Services {📦}
- Crossref