
NCBI . NLM . NIH . GOV {
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Title[redir]:
Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling - PMC
Description:
We studied interscapular brown adipose tissue (iBAT) activity in wild-type (WT) and glucagon-like peptide 1 receptor (GLP-1R)âdeficient mice after the administration of the proglucagon-derived peptides (PGDPs) glucagon-like peptide (GLP-1), glucagon ...
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Keywords {đ}
ibat, mice, oxm, glpr, icv, doi, thermogenesis, gcg, fig, pubmed, google, scholar, glp, temperature, control, increase, weight, body, increased, bat, expression, data, food, energy, receptor, signaling, cold, gcgr, intake, brown, activation, pmc, activity, effect, significantly, tissue, peptide, response, adipose, administration, glucagon, vehicle, glucagonlike, article, increases, metabolism, acute, exposure, expenditure, free,
Topics {âď¸}
dopamine β-hydroxylaseâdeficient mice pharmacological cnsâglp-1r contributes repeated-measures anova shows cnsâglp-1r simultaneously regulates cnsâglp-1r signaling contributes pre-proglucagon-derived peptides glp-1 δ-δ ct method pmc beta search blunt-dissected pocket underneath including circadian-dependent oscillations endogenous glp-1r signaling cnsâglp-1r signaling gene-specific taqman assays cnsâglp-1 signaling contributes hindbrain glp-1r signaling glp-1râdeficient littermates repeated-measures anova cns-gcg signaling remains central glp-1r activation cns-mediated bat thermogenesis cnsâglp-1r induction glp-1râdependent increase body weightâreducing effect cnsâglp-1r control publisher site pdf performed hyperinsulinemic-euglycemic clamps bat-derived fgf21 remains methods peptide synthesis diet-induced obese mice brown adipose tissue glp-1r knockout mice white adipose tissue adrenergic receptor agonists high-fatâfed mice cold-induced ibat thermogenesis insulin-stimulated conditions gcg receptor agonist oxm-infused mice lost glp-1r agonists oxm icvâtreated mice tukey post hoc glucose infusion rate increases body temperature agonist eliminates obesity lean chow-fed mice novo nordisk pharma euglycemic-hyperinsulinemic clamps abundant monocarboxylate transporter reduced food intake similar body weights
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