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Title[redir]:
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance - PMC
Description:
Dipeptidyl peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of peptidases, is involved in the metabolic inactivation of a glucose-dependent insulinotropic hormone, glucagon-like peptide 1 (GLP-1), and other incretin hormones. Here, ...
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Keywords {🔍}
mice, dpiv, pubmed, google, scholar, doi, insulin, hfd, glp, levels, weight, obesity, body, diabetes, fig, resistance, reduced, intake, fed, energy, cell, pmc, food, weeks, significantly, increased, fat, cells, control, metabolic, gain, gene, hfdinduced, expression, glucose, maintained, hepatic, compared, improved, animals, mass, resistant, study, lfd, hfdfed, lipid, nlm, lacking, article, expenditure,
Topics {✒️}
hfd-fed dp-iv-/- mice glucose-dependent insulinotropic polypeptide lfd-fed dp-iv-/- mice pmc beta search fatty acid β-oxidation glucose-dependent insulinotropic hormone fed ad libitum gender-matched animals fed active white adipocytes including glucose-induced stimulation dp-iv confers resistance hfd-induced insulin resistance gene encoding dp-iv pair-fed wt mice high fat-induced obesity wt pair-fed group hfd-fed dpiv-/- animals hfd-fed wt mice insulin-positive β cells obesity-induced insulin resistance cd26/dp-iv-/- mice mice lacking dp-iv publisher site pdf hfd/stz-treated wt lfd-fed wt mice dp-iv-/- mice compared glucose-lowering efficacy dp-iv-/- mice contribute hepatic lipid accumulation lipid-laden cells dipeptidyl peptidase iv dp-iv activity pair-fed group brown adipose tissue hepatic lipid content hfd predictably exhibited hepatic fat oxidation hfd-induced hyperleptinemia hepatic fat content circulating insulin levels wt mice fed increasing lipid oxidation license information pmcid similar mice fed improved glucose tolerance improved glucose clearance dp-iv-/- mice dp-iv-/-mice plasma insulin levels promoting islet regeneration
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