We are analyzing https://link.springer.com/article/10.1007/s00109-025-02533-0.

Title:
DNA-RNA hybrids in inflammation: sources, immune response, and therapeutic implications | Journal of Molecular Medicine
Description:
Cytoplasmic DNA-RNA hybrids are emerging as important immunogenic nucleic acids, that were previously underappreciated. DNA-RNA hybrids, formed during cellular processes like transcription and replication, or by exogenous pathogens, are recognized by pattern recognition receptors (PRRs), including cGAS, DDX41, and TLR9, which trigger immune responses. Post-translational modifications (PTMs) including ubiquitination, phosphorylation, acetylation, and palmitoylation regulate the activity of PRRs and downstream signaling molecules, fine-tuning the immune response. Targeting enzymes involved in DNA-RNA hybrid metabolism and PTMs regulation offers therapeutic potential for inflammatory diseases. Herein, we discuss the sources, immune response, and therapeutic implications of DNA-RNA hybrids in inflammation, highlighting the significance of DNA-RNA hybrids as potential targets for the treatment of inflammation.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, wang, zhang, liu, cell, dna, chen, immune, httpsdoiorgs, immunol, innate, nat, response, yang, zhou, mol, huang, sting, trim, hybrids, immunity, regulates, cancer, pathway, zhu, signaling, antiviral, zhao, sun, cgas, res, jin, rnadna, lin, biol, inflammation, virus, promotes, dnarna, responses, cgassting, httpsdoiorg, protein, jiang, commun,

Topics {✒️}

lkb1/ampk/ulk1-mediated autophagy month download article/chapter aicardi-goutieres syndrome due aicardi-goutieres syndrome presenting acy-1215 exhibits anti-inflammatory dna virus-triggered response rna-dna interactome complexity ubiquitin-proteasome pathway inhibitor cul3-e3 ligases mediated x-linked intellectual disability pi3k/akt/mtor pathway cgas-cgamp-sting pathway cgas/sting signaling dependent process rna-dna hybrids rna virus-induced production dna-rna hybrid metabolism akt kinase-mediated checkpoint dna hybrid accumulation related subjects nf-kappab signaling pathways intracellular double-stranded dna promote xrn2-dependent termination covalent small-molecule inhibitors iqgap1-cdc42 signaling axis trim21/eloa/lhpp axis aicardi-goutieres syndrome aicardi goutieres syndrome pristane-induced lupus model suppressing k48-linked ubiquitination deconjugating k48-linked ubiquitination anti-ssa 60kda antibodies cyclic gmp-amp synthase genome-wide dna hypomethylation ros-induced dub inhibition anti-dna virus immunity development ubiquitin-specific peptidase deconjugating k63-linked ubiquitination sensing r-loop innate immune response accepted manuscript version anti-cancer therapy full article pdf dna hybrids activate innate immune signaling cellular antiviral response selective autophagy controls trigger immune responses e3 ligase ube4a sting-dependent signaling adaptive immune responses

Schema {🗺️}

WebPage:
      mainEntity:
         headline:DNA-RNA hybrids in inflammation: sources, immune response, and therapeutic implications
         description:Cytoplasmic DNA-RNA hybrids are emerging as important immunogenic nucleic acids, that were previously underappreciated. DNA-RNA hybrids, formed during cellular processes like transcription and replication, or by exogenous pathogens, are recognized by pattern recognition receptors (PRRs), including cGAS, DDX41, and TLR9, which trigger immune responses. Post-translational modifications (PTMs) including ubiquitination, phosphorylation, acetylation, and palmitoylation regulate the activity of PRRs and downstream signaling molecules, fine-tuning the immune response. Targeting enzymes involved in DNA-RNA hybrid metabolism and PTMs regulation offers therapeutic potential for inflammatory diseases. Herein, we discuss the sources, immune response, and therapeutic implications of DNA-RNA hybrids in inflammation, highlighting the significance of DNA-RNA hybrids as potential targets for the treatment of inflammation.
         datePublished:2025-03-25T00:00:00Z
         dateModified:2025-03-25T00:00:00Z
         pageStart:511
         pageEnd:529
         sameAs:https://doi.org/10.1007/s00109-025-02533-0
         keywords:
            DNA-RNA hybrids
            cGAS-STING pathway
            Immune response
            PTMs regulation
            Inflammatory therapy
            Molecular Medicine
            Human Genetics
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-025-02533-0/MediaObjects/109_2025_2533_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-025-02533-0/MediaObjects/109_2025_2533_Fig2_HTML.jpg
         isPartOf:
            name:Journal of Molecular Medicine
            issn:
               1432-1440
               0946-2716
            volumeNumber:103
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer Berlin Heidelberg
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Litao Chen
               affiliation:
                     name:Ningbo University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lechen Hu
               affiliation:
                     name:Ningbo University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Han Chang
               affiliation:
                     name:Ningbo University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jianing Mao
               affiliation:
                     name:Ningbo University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Meng Ye
               affiliation:
                     name:Ningbo University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Xiaofeng Jin
               url:http://orcid.org/0000-0003-0801-8638
               affiliation:
                     name:Ningbo University
                     address:
                        name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:DNA-RNA hybrids in inflammation: sources, immune response, and therapeutic implications
      description:Cytoplasmic DNA-RNA hybrids are emerging as important immunogenic nucleic acids, that were previously underappreciated. DNA-RNA hybrids, formed during cellular processes like transcription and replication, or by exogenous pathogens, are recognized by pattern recognition receptors (PRRs), including cGAS, DDX41, and TLR9, which trigger immune responses. Post-translational modifications (PTMs) including ubiquitination, phosphorylation, acetylation, and palmitoylation regulate the activity of PRRs and downstream signaling molecules, fine-tuning the immune response. Targeting enzymes involved in DNA-RNA hybrid metabolism and PTMs regulation offers therapeutic potential for inflammatory diseases. Herein, we discuss the sources, immune response, and therapeutic implications of DNA-RNA hybrids in inflammation, highlighting the significance of DNA-RNA hybrids as potential targets for the treatment of inflammation.
      datePublished:2025-03-25T00:00:00Z
      dateModified:2025-03-25T00:00:00Z
      pageStart:511
      pageEnd:529
      sameAs:https://doi.org/10.1007/s00109-025-02533-0
      keywords:
         DNA-RNA hybrids
         cGAS-STING pathway
         Immune response
         PTMs regulation
         Inflammatory therapy
         Molecular Medicine
         Human Genetics
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-025-02533-0/MediaObjects/109_2025_2533_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs00109-025-02533-0/MediaObjects/109_2025_2533_Fig2_HTML.jpg
      isPartOf:
         name:Journal of Molecular Medicine
         issn:
            1432-1440
            0946-2716
         volumeNumber:103
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer Berlin Heidelberg
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Litao Chen
            affiliation:
                  name:Ningbo University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lechen Hu
            affiliation:
                  name:Ningbo University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Han Chang
            affiliation:
                  name:Ningbo University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jianing Mao
            affiliation:
                  name:Ningbo University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Meng Ye
            affiliation:
                  name:Ningbo University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Xiaofeng Jin
            url:http://orcid.org/0000-0003-0801-8638
            affiliation:
                  name:Ningbo University
                  address:
                     name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Molecular Medicine
      issn:
         1432-1440
         0946-2716
      volumeNumber:103
Organization:
      name:Springer Berlin Heidelberg
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Ningbo University
      address:
         name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
         type:PostalAddress
      name:Ningbo University
      address:
         name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
         type:PostalAddress
      name:Ningbo University
      address:
         name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
         type:PostalAddress
      name:Ningbo University
      address:
         name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
         type:PostalAddress
      name:Ningbo University
      address:
         name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
         type:PostalAddress
      name:Ningbo University
      address:
         name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Litao Chen
      affiliation:
            name:Ningbo University
            address:
               name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
               type:PostalAddress
            type:Organization
      name:Lechen Hu
      affiliation:
            name:Ningbo University
            address:
               name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
               type:PostalAddress
            type:Organization
      name:Han Chang
      affiliation:
            name:Ningbo University
            address:
               name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
               type:PostalAddress
            type:Organization
      name:Jianing Mao
      affiliation:
            name:Ningbo University
            address:
               name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
               type:PostalAddress
            type:Organization
      name:Meng Ye
      affiliation:
            name:Ningbo University
            address:
               name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Xiaofeng Jin
      url:http://orcid.org/0000-0003-0801-8638
      affiliation:
            name:Ningbo University
            address:
               name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
      name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
      name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
      name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
      name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
      name:Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Ningbo University, Ningbo, China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(845)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref
Pbgrd

5.39s.

LINK . SPRINGER . COM {}