
NCBI . NLM . NIH . GOV {
}
Title[redir]:
USP13 negatively regulates antiviral responses by deubiquitinating STING - PMC
Description:
STING (also known as MITA) is critical for host defence against viruses and the activity of STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully understood. Here, we show that ubiquitin-specific protease 13 ...
Matching Content Categories {π}
- Science
- Education
- Careers
Content Management System {π}
What CMS is ncbi.nlm.nih.gov built with?
Custom-built
No common CMS systems were detected on Ncbi.nlm.nih.gov, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of ncbi.nlm.nih.gov audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Ncbi.nlm.nih.gov Make Money? {πΈ}
We donβt know how the website earns money.
Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Ncbi.nlm.nih.gov might be making money, but it's not detectable how they're doing it.
Keywords {π}
usp, sting, cells, hsv, fig, analysis, mice, infection, supplementary, uspmm, doi, pubmed, google, scholar, ubiquitination, dna, pmc, signalling, article, data, immunoblot, free, antiviral, innate, immune, expression, bmdcs, transfected, klinked, viral, activation, irf, thp, deubiquitination, tbk, cell, mefs, protein, compared, infected, response, type, mouse, uspae, activity, rna, ubiquitin, responses, results, virustriggered,
Topics {βοΈ}
germline-encoded pattern-recognition receptors crispr/cas9-mediated genome editing antagonizing amfr/gp78-mediated ubiquitination hrp-conjugated goat-anti mouse cyclic gmp-amp synthase k27r-linked polyubiquitin chains k63-linked polyubiquitin chains amfr/gp78 significantly dampened mediates k27-linked ubiquitination activates rig-i-mavs signalling messengers cyclic-di-amp remove k29-linked ubiquitination pmc beta search examined virus-triggered ubiquitination intracellular double-stranded dna k63-linked ubiquitination mediated tk-renilla luciferase reporter ligand-type dependent manners4 dna-dependent inflammatory disease drs bao-liang song hsv-1-triggered signalling requires examined virus-triggered induction rig-i-dependent sensing gene encoding Ξ²-actin removed k27-linked ubiquitination deubiquitinate k29-linked ubiquitination quantitative real-time pcr virus-triggered signalling plasmids encoding flag-mita additional information including dna-dependent activator dna virus-triggered pattern recognition receptors cyclic gmp-amp rna polymerase iii license information pmcid interferon-dependent innate immunity plasmids encoding flag-usp13 k48-linked ubiquitination restrict antiviral responses targeting mita/sting protein plasmids encoding flag-sting ifn-triggered signalling mouse anti-Ξ²-actin bone marrow culture k27-linked ubiquitination k33-linked ubiquitination wild-type c57bl/6 mice cyclic-di-gmp supplementary materials included
Social Networks {π}(6)
External Links {π}(92)
- Learn about the earnings of https://doi.org/10.1038/ncomms15534
- What's the financial intake of http://creativecommons.org/licenses/by/4.0/?
- Monthly income for https://doi.org/10.1016/j.cell.2010.01.022
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Cell&title=Pattern%20recognition%20receptors%20and%20inflammation&author=O.%20Takeuchi&author=S.%20Akira&volume=140&publication_year=2010&pages=805-820&pmid=20303872&doi=10.1016/j.cell.2010.01.022&
- Find out how much https://doi.org/10.1016/j.immuni.2016.04.002 earns monthly
- Revenue of https://scholar.google.com/scholar_lookup?journal=Immunity&title=Recognition%20of%20endogenous%20nucleic%20acids%20by%20the%20innate%20immune%20system&author=A.%20Roers&author=B.%20Hiller&author=V.%20Hornung&volume=44&publication_year=2016&pages=739-754&pmid=27096317&doi=10.1016/j.immuni.2016.04.002&
- Get to know what's the income of https://doi.org/10.1146/annurev-immunol-032713-120156
- Explore the financials of https://scholar.google.com/scholar_lookup?journal=Annu.%20Rev.%20Immunol.&title=Innate%20immune%20sensing%20and%20signaling%20of%20cytosolic%20nucleic%20acids&author=J.%20Wu&author=Z.%20J.%20Chen&volume=32&publication_year=2014&pages=461-488&pmid=24655297&doi=10.1146/annurev-immunol-032713-120156&
- https://doi.org/10.1038/nature06013's financial summary
- https://scholar.google.com/scholar_lookup?journal=Nature&title=DAI%20(DLM-1/ZBP1)%20is%20a%20cytosolic%20DNA%20sensor%20and%20an%20activator%20of%20innate%20immune%20response&author=A.%20Takaoka&volume=448&publication_year=2007&pages=501-505&pmid=17618271&doi=10.1038/nature06013& income
- Profit of https://doi.org/10.1016/j.cell.2009.06.015
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Cell&title=RNA%20polymerase%20III%20detects%20cytosolic%20DNA%20and%20induces%20type%20I%20interferons%20through%20the%20RIG-I%20pathway&author=Y.%20H.%20Chiu&author=J.%20B.%20Macmillan&author=Z.%20J.%20Chen&volume=138&publication_year=2009&pages=576-591&pmid=19631370&doi=10.1016/j.cell.2009.06.015&?
- Income figures for https://doi.org/10.1038/ni.1779
- How much profit does https://scholar.google.com/scholar_lookup?journal=Nat.%20Immunol.&title=RIG-I-dependent%20sensing%20of%20poly(dA:dT)%20through%20the%20induction%20of%20an%20RNA%20polymerase%20III-transcribed%20RNA%20intermediate&author=A.%20Ablasser&volume=10&publication_year=2009&pages=1065-1072&pmid=19609254&doi=10.1038/ni.1779& generate?
- What's the financial intake of https://doi.org/10.1038/ni.1932?
- What is the earnings of https://scholar.google.com/scholar_lookup?journal=Nat.%20Immunol.&title=IFI16%20is%20an%20innate%20immune%20sensor%20for%20intracellular%20DNA&author=L.%20Unterholzner&volume=11&publication_year=2010&pages=997-1004&pmid=20890285&doi=10.1038/ni.1932&?
- Discover the revenue of https://doi.org/10.1038/ni.2091
- How much cash flow does https://scholar.google.com/scholar_lookup?journal=Nat.%20Immunol.&title=The%20helicase%20DDX41%20senses%20intracellular%20DNA%20mediated%20by%20the%20adaptor%20STING%20in%20dendritic%20cells&author=Z.%20Zhang&volume=12&publication_year=2011&pages=959-965&pmid=21892174&doi=10.1038/ni.2091& have monthly?
- https://doi.org/10.1073/pnas.1203405109's total income per month
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl%20Acad.%20Sci.%20USA&title=LSm14A%20is%20a%20processing%20body-associated%20sensor%20of%20viral%20nucleic%20acids%20that%20initiates%20cellular%20antiviral%20response%20in%20the%20early%20phase%20of%20viral%20infection&author=Y.%20Li&volume=109&publication_year=2012&pages=11770-11775&pmid=22745163&doi=10.1073/pnas.1203405109&?
- What are the total earnings of https://doi.org/10.1126/science.1232458?
- How much does https://scholar.google.com/scholar_lookup?journal=Science&title=Cyclic%20GMP-AMP%20synthase%20is%20a%20cytosolic%20DNA%20sensor%20that%20activates%20the%20type%20I%20interferon%20pathway&author=L.%20Sun&author=J.%20Wu&author=F.%20Du&author=X.%20Chen&author=Z.%20J.%20Chen&volume=339&publication_year=2013&pages=786-791&pmid=23258413&doi=10.1126/science.1232458& rake in every month?
- Profit of https://doi.org/10.1016/j.cell.2013.04.046
- See how much https://scholar.google.com/scholar_lookup?journal=Cell&title=Cyclic%20%5BG(2%E2%80%B2,5%E2%80%B2)pA(3%E2%80%B2,5%E2%80%B2)p%5D%20is%20the%20metazoan%20second%20messenger%20produced%20by%20DNA-activated%20cyclic%20GMP-AMP%20synthase&author=P.%20Gao&volume=153&publication_year=2013&pages=1094-1107&pmid=23647843&doi=10.1016/j.cell.2013.04.046& makes per month
- How much money does https://doi.org/10.1038/nature12306 generate?
- Profit of https://scholar.google.com/scholar_lookup?journal=Nature&title=cGAS%20produces%20a%202%E2%80%B2-5%E2%80%B2-linked%20cyclic%20dinucleotide%20second%20messenger%20that%20activates%20STING&author=A.%20Ablasser&volume=498&publication_year=2013&pages=380-384&pmid=23722158&doi=10.1038/nature12306&
- https://doi.org/10.1016/j.immuni.2008.09.003's financial summary
- Financial intake of https://scholar.google.com/scholar_lookup?journal=Immunity&title=The%20adaptor%20protein%20MITA%20links%20virus-sensing%20receptors%20to%20IRF3%20transcription%20factor%20activation&author=B.%20Zhong&volume=29&publication_year=2008&pages=538-550&pmid=18818105&doi=10.1016/j.immuni.2008.09.003&
- How much cash flow does https://doi.org/10.1038/nature07317 have monthly?
- How much does https://scholar.google.com/scholar_lookup?journal=Nature&title=STING%20is%20an%20endoplasmic%20reticulum%20adaptor%20that%20facilitates%20innate%20immune%20signalling&author=H.%20Ishikawa&author=G.%20N.%20Barber&volume=455&publication_year=2008&pages=674-678&pmid=18724357&doi=10.1038/nature07317& generate monthly?
- What's the financial gain of https://doi.org/10.1073/pnas.0900850106?
- Income figures for https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl%20Acad.%20Sci.%20USA&title=ERIS,%20an%20endoplasmic%20reticulum%20IFN%20stimulator,%20activates%20innate%20immune%20signaling%20through%20dimerization&author=W.%20Sun&volume=106&publication_year=2009&pages=8653-8658&pmid=19433799&doi=10.1073/pnas.0900850106&
- How much money does https://doi.org/10.4049/jimmunol.1100088 generate?
- Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Immunol.&title=MPYS%20is%20required%20for%20IFN%20response%20factor%203%20activation%20and%20type%20I%20IFN%20production%20in%20the%20response%20of%20cultured%20phagocytes%20to%20bacterial%20second%20messengers%20cyclic-di-AMP%20and%20cyclic-di-GMP&author=L.%20Jin&volume=187&publication_year=2011&pages=2595-2601&pmid=21813776&doi=10.4049/jimmunol.1100088&
- What is the earnings of https://doi.org/10.1126/science.1229963?
- What's the revenue for https://scholar.google.com/scholar_lookup?journal=Science&title=Cyclic%20GMP-AMP%20is%20an%20endogenous%20second%20messenger%20in%20innate%20immune%20signaling%20by%20cytosolic%20DNA&author=J.%20Wu&volume=339&publication_year=2013&pages=826-830&pmid=23258412&doi=10.1126/science.1229963&?
- What's the financial intake of https://doi.org/10.1016/j.molcel.2014.03.040?
- Discover the revenue of https://scholar.google.com/scholar_lookup?journal=Mol.%20Cell&title=The%20cGAS-cGAMP-STING%20pathway%20of%20cytosolic%20DNA%20sensing%20and%20signaling&author=X.%20Cai&author=Y.%20H.%20Chiu&author=Z.%20J.%20Chen&volume=54&publication_year=2014&pages=289-296&pmid=24766893&doi=10.1016/j.molcel.2014.03.040&
- Earnings of https://doi.org/10.1038/ni.2756
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=Nat.%20Immunol.&title=ELF4%20is%20critical%20for%20induction%20of%20type%20I%20interferon%20and%20the%20host%20antiviral%20response&author=F.%20You&volume=14&publication_year=2013&pages=1237-1246&pmid=24185615&doi=10.1038/ni.2756&?
- How much does https://doi.org/10.1038/ncomms10680 gross monthly?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Nat.%20Commun.&title=Influenza%20A%20virus%20targets%20a%20cGAS-independent%20STING%20pathway%20that%20controls%20enveloped%20RNA%20viruses&author=C.%20K.%20Holm&volume=7&publication_year=2016&pages=10680&pmid=26893169&doi=10.1038/ncomms10680&?
- Discover the revenue of https://doi.org/10.1073/pnas.1215006109
- How profitable is https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl%20Acad.%20Sci.%20USA&title=STING%20manifests%20self%20DNA-dependent%20inflammatory%20disease&author=J.%20Ahn&author=D.%20Gutman&author=S.%20Saijo&author=G.%20N.%20Barber&volume=109&publication_year=2012&pages=19386-19391&pmid=23132945&doi=10.1073/pnas.1215006109&?
- How much does https://doi.org/10.1056/NEJMoa1312625 rake in every month?
- See how much https://scholar.google.com/scholar_lookup?journal=N.%20Engl.%20J.%20Med.&title=Activated%20STING%20in%20a%20vascular%20and%20pulmonary%20syndrome&author=Y.%20Liu&volume=371&publication_year=2014&pages=507-518&pmid=25029335&doi=10.1056/NEJMoa1312625& makes per month
- Check the income stats for https://doi.org/10.1016/j.immuni.2010.10.013
- How much does https://scholar.google.com/scholar_lookup?journal=Immunity&title=The%20ubiquitin%20ligase%20TRIM56%20regulates%20innate%20immune%20responses%20to%20intracellular%20double-stranded%20DNA&author=T.%20Tsuchida&volume=33&publication_year=2010&pages=765-776&pmid=21074459&doi=10.1016/j.immuni.2010.10.013& generate monthly?
- Explore the financials of https://doi.org/10.1074/jbc.M112.362608
- How much money does https://scholar.google.com/scholar_lookup?journal=J.%20Biol.%20Chem.&title=TRIM32%20protein%20modulates%20type%20I%20interferon%20induction%20and%20cellular%20antiviral%20response%20by%20targeting%20MITA/STING%20protein%20for%20K63-linked%20ubiquitination&author=J.%20Zhang&author=M.%20M.%20Hu&author=Y.%20Y.%20Wang&author=H.%20B.%20Shu&volume=287&publication_year=2012&pages=28646-28655&pmid=22745133&doi=10.1074/jbc.M112.362608& make?
- What's the financial outcome of https://doi.org/10.1016/j.immuni.2009.01.008?
- Learn about the earnings of https://scholar.google.com/scholar_lookup?journal=Immunity&title=The%20ubiquitin%20ligase%20RNF5%20regulates%20antiviral%20responses%20by%20mediating%20degradation%20of%20the%20adaptor%20protein%20MITA&author=B.%20Zhong&volume=30&publication_year=2009&pages=397-407&pmid=19285439&doi=10.1016/j.immuni.2009.01.008&
- Income figures for https://doi.org/10.1371/journal.ppat.1004358
- Learn how profitable https://scholar.google.com/scholar_lookup?journal=PLoS%20Pathogens&title=RNF26%20temporally%20regulates%20virus-triggered%20type%20I%20interferon%20induction%20by%20two%20distinct%20mechanisms&author=Y.%20Qin&volume=10&publication_year=2014&pages=e1004358&pmid=25254379&doi=10.1371/journal.ppat.1004358& is on a monthly basis
- What are the total earnings of https://doi.org/10.1016/j.immuni.2014.11.011?
- See how much https://scholar.google.com/scholar_lookup?journal=Immunity&title=The%20E3%20ubiquitin%20ligase%20AMFR%20and%20INSIG1%20bridge%20the%20activation%20of%20TBK1%20kinase%20by%20modifying%20the%20adaptor%20STING&author=Q.%20Wang&volume=41&publication_year=2014&pages=919-933&pmid=25526307&doi=10.1016/j.immuni.2014.11.011& makes per month
- What's the monthly money flow for https://doi.org/10.1016/j.cell.2011.08.037?
- How much does https://scholar.google.com/scholar_lookup?journal=Cell&title=Beclin1%20controls%20the%20levels%20of%20p53%20by%20regulating%20the%20deubiquitination%20activity%20of%20USP10%20and%20USP13&author=J.%20Liu&volume=147&publication_year=2011&pages=223-234&pmid=21962518&doi=10.1016/j.cell.2011.08.037& pull in monthly?
- https://doi.org/10.1038/ncb2874's total income per month
- How much does https://scholar.google.com/scholar_lookup?journal=Nat.%20Cell%20Biol.&title=Deubiquitylation%20and%20stabilization%20of%20PTEN%20by%20USP13&author=J.%20Zhang&volume=15&publication_year=2013&pages=1486-1494&pmid=24270891&doi=10.1038/ncb2874& generate monthly?
- What is the earnings of https://doi.org/10.1038/ncomms1421?
- Explore the financials of https://scholar.google.com/scholar_lookup?journal=Nat.%20Commun.&title=Regulation%20of%20MITF%20stability%20by%20the%20USP13%20deubiquitinase&author=X.%20Zhao&author=B.%20Fiske&author=A.%20Kawakami&author=J.%20Li&author=D.%20E.%20Fisher&volume=2&publication_year=2011&pages=414&pmid=21811243&doi=10.1038/ncomms1421&
- What's the total monthly financial gain of https://doi.org/10.4049/jimmunol.1300225?
- What are the total earnings of https://scholar.google.com/scholar_lookup?journal=J.%20Immunol.&title=Ubiquitin-specific%20protease%2013%20regulates%20IFN%20signaling%20by%20stabilizing%20STAT1&author=H.%20M.%20Yeh&volume=191&publication_year=2013&pages=3328-3336&pmid=23940278&doi=10.4049/jimmunol.1300225&?
- What's the income generated by https://doi.org/10.7554/eLife.01369 each month?
- What's https://scholar.google.com/scholar_lookup?journal=eLife&title=USP13%20antagonizes%20gp78%20to%20maintain%20functionality%20of%20a%20chaperone%20in%20ER-associated%20degradation&author=Y.%20Liu&volume=3&publication_year=2014&pages=e01369&pmid=24424410&doi=10.7554/eLife.01369&'s gross income?
- Monthly income for https://doi.org/10.1016/j.cytogfr.2014.05.003
- What's the profit of https://scholar.google.com/scholar_lookup?journal=Cytokine%20Growth%20Factor%20Rev.&title=MITA/STING:%20a%20central%20and%20multifaceted%20mediator%20in%20innate%20immune%20response&author=Y.%20Ran&author=H.%20B.%20Shu&author=Y.%20Y.%20Wang&volume=25&publication_year=2014&pages=631-639&pmid=24929887&doi=10.1016/j.cytogfr.2014.05.003&?
- How much income is https://doi.org/10.1038/nature08476 earning monthly?
- Get to know https://scholar.google.com/scholar_lookup?journal=Nature&title=STING%20regulates%20intracellular%20DNA-mediated,%20type%20I%20interferon-dependent%20innate%20immunity&author=H.%20Ishikawa&author=Z.%20Ma&author=G.%20N.%20Barber&volume=461&publication_year=2009&pages=788-792&pmid=19776740&doi=10.1038/nature08476&'s earnings
- Discover the revenue of https://doi.org/10.1073/pnas.1420217112
- Check the income stats for https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl%20Acad.%20Sci.%20USA&title=Suppression%20of%20systemic%20autoimmunity%20by%20the%20innate%20immune%20adaptor%20STING&author=S.%20Sharma&volume=112&publication_year=2015&pages=E710-E717&pmid=25646421&doi=10.1073/pnas.1420217112&
- Check the income stats for https://doi.org/10.1038/cr.2016.125
- How much money does https://scholar.google.com/scholar_lookup?journal=Cell%20Res.&title=USP18%20recruits%20USP20%20to%20promote%20innate%20antiviral%20response%20through%20deubiquitinating%20STING/MITA&author=M.%20Zhang&volume=26&publication_year=2016&pages=1302-1319&pmid=27801882&doi=10.1038/cr.2016.125& make?
- https://doi.org/10.1073/pnas.1509968112's total income per month
- Monthly income for https://scholar.google.com/scholar_lookup?journal=Proc.%20Natl%20Acad.%20Sci.%20USA&title=Induction%20of%20USP25%20by%20viral%20infection%20promotes%20innate%20antiviral%20responses%20by%20mediating%20the%20stabilization%20of%20TRAF3%20and%20TRAF6&author=D.%20Lin&volume=112&publication_year=2015&pages=11324-11329&pmid=26305951&doi=10.1073/pnas.1509968112&
- How much does https://doi.org/10.1016/j.chom.2014.09.006 pull in monthly?
- What's the monthly income of https://scholar.google.com/scholar_lookup?journal=Cell%20Host%20Microbe&title=The%20ER-associated%20protein%20ZDHHC1%20is%20a%20positive%20regulator%20of%20DNA%20virus-triggered,%20MITA/STING-dependent%20innate%20immune%20signaling&author=Q.%20Zhou&volume=16&publication_year=2014&pages=450-461&pmid=25299331&doi=10.1016/j.chom.2014.09.006&?
- How much profit is https://doi.org/10.1038/ni.3510 making per month?
- What's the financial gain of https://scholar.google.com/scholar_lookup?journal=Nat.%20Immunol.&title=iRhom2%20is%20essential%20for%20innate%20immunity%20to%20DNA%20viruses%20by%20mediating%20trafficking%20and%20stability%20of%20the%20adaptor%20STING&author=W.%20W.%20Luo&volume=17&publication_year=2016&pages=1057-1066&pmid=27428826&doi=10.1038/ni.3510&?
- What's https://github.com/ncbi's gross income?
- How much does https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/%4038.9959508, -77.101021,17z/data%3D!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb%3A0x19156f88b27635b8!8m2!3d38.9959508! 4d-77.0988323 earn?
- What's the financial intake of https://www.nlm.nih.gov/web_policies.html?
- See how much https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office makes per month
- What's the monthly income of https://www.hhs.gov/vulnerability-disclosure-policy/index.html?
- What's the financial outcome of https://support.nlm.nih.gov/?pagename=cloudpmc-viewer%3Apmc%3Aarticle%3Ajournal?
- What are the total earnings of https://www.nlm.nih.gov/accessibility.html?
- Get to know what's the income of https://www.nlm.nih.gov/careers/careers.html
- How much income does https://www.nlm.nih.gov/ have?
- How much does https://www.nih.gov/ pull in?
- Earnings of https://www.hhs.gov/
- How much money does https://www.usa.gov/ make?
Analytics and Tracking {π}
- Google Analytics
- Google Analytics 4
- Google Tag Manager
Libraries {π}
- jQuery
- jQuery module (jquery-3.6.0)
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- nihcesxway.hub.nih.gov
- nihcesxway2.hub.nih.gov
- nihcesxway3.hub.nih.gov
- nihcesxway4.hub.nih.gov
- nihcesxway5.hub.nih.gov
Name Servers:
- dns1-ncbi.ncbi.nlm.nih.gov
- dns2-ncbi.ncbi.nlm.nih.gov
- lhcns1.nlm.nih.gov
- lhcns2.nlm.nih.gov
CDN Services {π¦}
- Ncbi