We are analyzing https://link.springer.com/article/10.1007/s00018-018-2908-7.

Title:
Epigenetic mechanisms of tumor resistance to immunotherapy | Cellular and Molecular Life Sciences
Description:
The recent impact of cancer immunotherapies has firmly established the ability and importance of the immune system to fight malignancies. However, the intimate interaction between the highly dynamic tumor and immune cells leads to a selection process driven by genetic and epigenetic processes. As the molecular pathways of cancer resistance mechanisms to immunotherapy become increasingly known, novel therapeutic targets are being tested in combination with immune-stimulating approaches. We here review recent insights into the molecular mechanisms of tumor resistance with particular emphasis on epigenetic processes and place these in the context of previous models.
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Keywords {🔍}

pubmed, google, scholar, cas, cancer, central, cell, cells, epigenetic, immunol, tumor, immune, nat, ezh, expression, resistance, immunotherapy, med, methylation, histone, article, immunity, res, nature, antigen, melanoma, rev, regulation, dna, molecular, role, treatment, sci, blockade, science, therapy, regulates, regulatory, mechanisms, arenasramirez, boyman, tumour, lung, myeloid, tcell, response, checkpoint, human, effector, antitumor,

Topics {✒️}

cd25-dependent immunoregulatory mechanisms inflammation-induced reversible dedifferentiation month download article/chapter cd25-mimobody conferring selectivity chromatin-modifying enzyme ezh2 immune escape mechanisms myeloid-derived suppressor cells antigen-specific ctl response demethylating agent 5-aza-2′-deoxycytidine natalia arenas-ramirez tumor-intrinsic immune resistance polycomb complex prc2 small-cell lung cancer ifn-gamma pathway genes t-cell-dependent mechanism prostate cancer-testis antigen tumoricidal t-cell trafficking nk/t-cell lines article arenas-ramirez twenty promoter-cpg islands distinct tumour suppressors combination targeted therapy-immunotherapy dna methylation inhibitor anti-ctla-4 therapy prc2-mediated regulation histone deacetylase inhibitors tgf beta signaling related subjects cancer-germline gene cd8+ t-cell response ctla-4 blockade relies lineage-specific transition mage-1 tumor antigen tumour vascular checkpoints immune checkpoint blockade ezh2 regulates differentiation privacy choices/manage cookies histone acetylation regulates pten promotes resistance histone methyltransferase activity anti-tumor immunity inhibitory immune checkpoint tumor antigen encoded tumour antigens recognized cell-mediated immunotherapy pd-1 blockade mediated killer cell ig myeloid-derived cells cancer/testis antigens cancer-testis antigens

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         description:The recent impact of cancer immunotherapies has firmly established the ability and importance of the immune system to fight malignancies. However, the intimate interaction between the highly dynamic tumor and immune cells leads to a selection process driven by genetic and epigenetic processes. As the molecular pathways of cancer resistance mechanisms to immunotherapy become increasingly known, novel therapeutic targets are being tested in combination with immune-stimulating approaches. We here review recent insights into the molecular mechanisms of tumor resistance with particular emphasis on epigenetic processes and place these in the context of previous models.
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