
NCBI . NLM . NIH . GOV {
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Title[redir]:
Inhibition of Histone Lysine Methylation Enhances Expression of Cancer-Testis Genes in Lung Cancer Cells: Implications for Adoptive Immunotherapy of Cancer - PMC
Description:
Cancer-testis antigens such as NY-ESO-1, MAGE-A1 and MAGE-A3 are immunogenic proteins encoded by genes, which are normally expressed only in male germ cells, but activated by ill-defined epigenetic mechanisms in human tumors including lung cancers. ...
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Keywords {🔍}
cells, magea, cancer, doi, nyeso, dznep, lung, ctx, genes, gene, pubmed, google, scholar, expression, kmt, figure, experiments, histone, analysis, dna, dac, pmc, promoters, hkme, methylation, knockdown, activation, article, dacdznep, levels, free, cell, treatment, normal, demethylation, tumor, panel, res, kdmb, dacmediated, lysine, effects, global, supplementary, effector, observed, cancertestis, kdm, nhbe, qrtpcr,
Topics {✒️}
3′-azido-3′-deoxythymidine-resistant hiv-1 strains mage-a3-specific tcr-engineered mage-a3 tcr-transduced pbls dac-dznep-treated h841-a2 cells genetically-engineered receptors recognizing fitc-labeled secondary antibodies hla-restricted ctls specific dac-treated h841-a2 cells hek293 overexpressing mage-a3 promoter-dependent mechanism leading pmc beta search mechanisms mediating de-repression nonvaccine anti-tumor cells /ebp-beta-mediated activation dac-mediated cytokine release dznep enhances dac-mediated s-adenosylhomocysteine hydrolase inhibition cell-mediated immune responses increased interferon-γ release cancer/testis antigen expression qrt-pcr experiments revealed dac-mediated de-repression decitabine-mediated gene expression cigarette smoke induces unmethylated mage-a1 transgenes ill-defined epigenetic mechanisms augment dac-mediated ct qrt-pcr experiments demonstrated primary antibodies recognizing h1299-a2 cells served h841-a2 cells treated mage-a12 encoding hla mage-a3 promoter methylation low-dose dac-dznep ny-eso-1 promoter coincides chip-grade antibodies listed pcmv6-ac-gfp-kmt6 sequential dac/dp exposure mage-a3 effector cells low-level lysis genes including ny-eso-1 preliminary qrt-pcr primary silencing mechanism ny-eso-1 effector cells dac-dznep mediated activation expressing receptors specific ny-eso-1+ tumor cells mage-a3 promoter demethylation mage-a3 promoters coincided percent specific lysis
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