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We are analyzing https://www.nature.com/articles/srep25183.

Title:
Hepatocellular carcinoma: thyroid hormone promotes tumorigenicity through inducing cancer stem-like cell self-renewal | Scientific Reports
Description:
Cancer stem-like cells (CSCs) play a key role in maintaining the aggressiveness of hepatocellular carcinoma (HCC), but the cell-biological regulation of CSCs is unclear. In the study, we report that thyroid hormone (TH) promotes cell self-renewal in HCC cells. TH also increases the percentage of CD90 + HCC cells and promotes drug resistance of HCC cells. By analyzing primary human HCC samples, we found that TRα transcript level is significantly elevated in primary liver cancer and portal vein metastatic tumor, compared to that of adjacent normal liver tissue. Knocking down TRα not only inhibits HCC self-renewal in vitro but also suppresses HCC tumor growth in vivo. Interestingly, treatment of TH leads to activation of NF-κB, which is required for the function of TH on inducing HCC cell self-renewal. We also found TRα and p65 cooperatively drive the expression of BMI1 by co-binding to the promoter region of BMI1 gene. In summary, our study uncovers a novel function of TH signaling in regulating the CSCs of HCC and these findings might be useful for developing novel therapies by targeting TH function in HCC cells.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

cells, hcc, cancer, trα, article, cell, pubmed, csqt, google, scholar, tumor, doi, liver, cas, selfrenewal, expression, nature, nfκb, stem, function, bmi, fig, signaling, receptor, hepatocellular, carcinoma, thyroid, hormone, stemlike, cscs, central, data, gene, measured, receptors, essential, number, nuclear, treated, journal, resistance, studies, size, promotes, samples, regulating, shrna, days, analysis, wang,

Topics {✒️}

nature portfolio privacy policy integrin-nf-kappab-hif-1alpha pathway therapeutic index breast cancer research advertising clinical cancer research nature reviews nature communications 4 cancer research 21 nature 522 nature 526 nature 425 nature pparg-deleted prostate cells male nod/scid mice yu-xiong feng 0/ reprints single-cell based analysis single-cell analysis reveals china paracrine fgf/tbx3 signaling cancer cell chemo-resistance22 transforming growth factor-beta ultra-low attachment plates ultra-low attachment plate stem/progenitor cell physiology chip-pcr data demonstrated 2d colony-forming assay progenitor/stem cell biology lentivirus encoding lacz anti-p65 antibody overnight multiple canonical half-sites intrinsic multi-drug resistance tumor spheroid-based screening tissue-resident stem cells cancer development flow cytometry analyses nod/scid mice stem/progenitor cell features culture media permissions nf-κb subunit p65 social media hcc normal/primary tumor enhances drug-resistance full size image anti-human cd90 heightened chemo-resistance human tissue samples

Questions {❓}

  • Thyroid hormone’s action on progenitor/stem cell biology: new challenge for a classic hormone?

Schema {🗺️}

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         description:Cancer stem-like cells (CSCs) play a key role in maintaining the aggressiveness of hepatocellular carcinoma (HCC), but the cell-biological regulation of CSCs is unclear. In the study, we report that thyroid hormone (TH) promotes cell self-renewal in HCC cells. TH also increases the percentage of CD90 + HCC cells and promotes drug resistance of HCC cells. By analyzing primary human HCC samples, we found that TRα transcript level is significantly elevated in primary liver cancer and portal vein metastatic tumor, compared to that of adjacent normal liver tissue. Knocking down TRα not only inhibits HCC self-renewal in vitro but also suppresses HCC tumor growth in vivo. Interestingly, treatment of TH leads to activation of NF-κB, which is required for the function of TH on inducing HCC cell self-renewal. We also found TRα and p65 cooperatively drive the expression of BMI1 by co-binding to the promoter region of BMI1 gene. In summary, our study uncovers a novel function of TH signaling in regulating the CSCs of HCC and these findings might be useful for developing novel therapies by targeting TH function in HCC cells.
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      headline:Hepatocellular carcinoma: thyroid hormone promotes tumorigenicity through inducing cancer stem-like cell self-renewal
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            name:Renji Hospital, School of Medicine, Shanghai Jiaotong University
            address:
               name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
               type:PostalAddress
            type:Organization
      name:Ping Li
      affiliation:
            name:Renji Hospital, School of Medicine, Shanghai Jiaotong University
            address:
               name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
               type:PostalAddress
            type:Organization
      name:Yu-xiong Feng
      affiliation:
            name:Renji Hospital, School of Medicine, Shanghai Jiaotong University
            address:
               name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
               type:PostalAddress
            type:Organization
      name:Qiang Xia
      affiliation:
            name:Renji Hospital, School of Medicine, Shanghai Jiaotong University
            address:
               name:Department of Hepatic surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
               type:PostalAddress
            type:Organization
      name:Bo Zhai
      affiliation:
            name:Renji Hospital, School of Medicine, Shanghai Jiaotong University
            address:
               name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Hepatic surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Hepatic surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Hepatic surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Hepatic surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai
      name:Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai

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