
NATURE . COM {
}
Title:
Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence | Nature Communications
Description:
Cancer recurrence after initial diagnosis and treatment is a major cause of breast cancer (BC) mortality, which results from the metastatic outbreak of dormant tumour cells. Alterations in the tumour microenvironment can trigger signalling pathways in dormant cells leading to their proliferation. However, processes involved in the initial and the long-term survival of disseminated dormant BC cells remain largely unknown. Here we show that autophagy is a critical mechanism for the survival of disseminated dormant BC cells. Pharmacologic or genetic inhibition of autophagy in dormant BC cells results in significantly decreased cell survival and metastatic burden in mouse and human 3D in vitro and in vivo preclinical models of dormancy. In vivo experiments identify autophagy gene autophagy-related 7 (ATG7) to be essential for autophagy activation. Mechanistically, inhibition of the autophagic flux in dormant BC cells leads to the accumulation of damaged mitochondria and reactive oxygen species (ROS), resulting in cell apoptosis. Highly metastatic dormant cancer cells contribute to breast cancer recurrence, but the underlying mechanism is less understood. Here, the authors show that dormant breast cancer cells depend on autophagy to ensure their long term survival and distant recurrence
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {๐}
- Science
- Education
- Health & Fitness
Content Management System {๐}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {๐}
What is the average monthly size of nature.com audience?
๐ Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,555,829 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {๐ธ}
Display Ads {๐ฏ}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {๐ฐ}
Display Ads {๐ฏ}
$536,300 per month
Our calculations suggest that Nature.com earns between $357,511 and $983,155 monthly online from display advertisements.
Keywords {๐}
cells, autophagy, bme, dormant, hcq, metastatic, day, fig, cell, pubmed, article, cancer, days, inhibition, google, scholar, culture, treatment, cas, data, tumour, treated, mice, comparisons, mitochondrial, col, sem, burden, compared, proliferative, supplementary, matrices, nature, survival, lung, assay, central, analysis, dormancy, vivo, fibrosis, results, twosided, autophagic, proliferation, significantly, vitro, observed, expression, wells,
Topics {โ๏ธ}
/product-category/physiologic-cell-culture/extracellular-matrix-proteins/ nature portfolio privacy policy andalusian regional ministry intramural research program thermo scientific anti-cyclophillin proliferative index determined advertising nature 529 nature tandem reporter mcherry-gfp-lc3 reprints col-i-enriched fibrotic environment thermo fisher scientific research cd1nu/nu athymic mice isolate mcherry-gfp-lc3 d2 article vera-ramirez cdnu/nu athymic mice mannโwhitney u-test tandem fluorescent-tagged lc3 library preparation cd1nu/nu mice injected adenovector-mediated gene transfer mcherry-gfp-lc3 cells showed mcherry-gfp-lc3 cells isolated 50โmg/kg body weight mcherry-gfp-lc3 cells grown social media complete media genitourinary medical oncology park2/parkin-dependent mitophagy mda-mb-231 cell lines initial orga-specific metastasis cytotox-glo cytoxocity assay frequent post-translational modifications develop oxidative-based therapies double-positive puncta permissions total tumour burden/lung mda-mb-231 viable cells full size image original author mcherry-gfp-lc3 cells lipidated form lc3-ii average tumour burden/lung adenovirus-null vector control ros-induced cell death murine mammary neoplasia injectedย d2a1-gfp cells
Schema {๐บ๏ธ}
WebPage:
mainEntity:
headline:Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence
description:Cancer recurrence after initial diagnosis and treatment is a major cause of breast cancer (BC) mortality, which results from the metastatic outbreak of dormant tumour cells. Alterations in the tumour microenvironment can trigger signalling pathways in dormant cells leading to their proliferation. However, processes involved in the initial and the long-term survival of disseminated dormant BC cells remain largely unknown. Here we show that autophagy is a critical mechanism for the survival of disseminated dormant BC cells. Pharmacologic or genetic inhibition of autophagy in dormant BC cells results in significantly decreased cell survival and metastatic burden in mouse and human 3D in vitro and in vivo preclinical models of dormancy. In vivo experiments identify autophagy gene autophagy-related 7 (ATG7) to be essential for autophagy activation. Mechanistically, inhibition of the autophagic flux in dormant BC cells leads to the accumulation of damaged mitochondria and reactive oxygen species (ROS), resulting in cell apoptosis. Highly metastatic dormant cancer cells contribute to breast cancer recurrence, but the underlying mechanism is less understood. Here, the authors show that dormant breast cancer cells depend on autophagy to ensure their long term survival and distant recurrence
datePublished:2018-05-22T00:00:00Z
dateModified:2018-05-22T00:00:00Z
pageStart:1
pageEnd:12
license:http://creativecommons.org/licenses/by/4.0/
sameAs:https://doi.org/10.1038/s41467-018-04070-6
keywords:
Breast cancer
Mitophagy
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig7_HTML.jpg
isPartOf:
name:Nature Communications
issn:
2041-1723
volumeNumber:9
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Laura Vera-Ramirez
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
type:Person
name:Suman K. Vodnala
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
type:Person
name:Ryan Nini
url:http://orcid.org/0000-0003-1201-0954
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Kent W. Hunter
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Jeffrey E. Green
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence
description:Cancer recurrence after initial diagnosis and treatment is a major cause of breast cancer (BC) mortality, which results from the metastatic outbreak of dormant tumour cells. Alterations in the tumour microenvironment can trigger signalling pathways in dormant cells leading to their proliferation. However, processes involved in the initial and the long-term survival of disseminated dormant BC cells remain largely unknown. Here we show that autophagy is a critical mechanism for the survival of disseminated dormant BC cells. Pharmacologic or genetic inhibition of autophagy in dormant BC cells results in significantly decreased cell survival and metastatic burden in mouse and human 3D in vitro and in vivo preclinical models of dormancy. In vivo experiments identify autophagy gene autophagy-related 7 (ATG7) to be essential for autophagy activation. Mechanistically, inhibition of the autophagic flux in dormant BC cells leads to the accumulation of damaged mitochondria and reactive oxygen species (ROS), resulting in cell apoptosis. Highly metastatic dormant cancer cells contribute to breast cancer recurrence, but the underlying mechanism is less understood. Here, the authors show that dormant breast cancer cells depend on autophagy to ensure their long term survival and distant recurrence
datePublished:2018-05-22T00:00:00Z
dateModified:2018-05-22T00:00:00Z
pageStart:1
pageEnd:12
license:http://creativecommons.org/licenses/by/4.0/
sameAs:https://doi.org/10.1038/s41467-018-04070-6
keywords:
Breast cancer
Mitophagy
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig6_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_Fig7_HTML.jpg
isPartOf:
name:Nature Communications
issn:
2041-1723
volumeNumber:9
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Laura Vera-Ramirez
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
type:Person
name:Suman K. Vodnala
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
type:Person
name:Ryan Nini
url:http://orcid.org/0000-0003-1201-0954
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Kent W. Hunter
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Jeffrey E. Green
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Nature Communications
issn:
2041-1723
volumeNumber:9
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Laura Vera-Ramirez
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
name:Suman K. Vodnala
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
name:Ryan Nini
url:http://orcid.org/0000-0003-1201-0954
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Kent W. Hunter
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
email:[email protected]
name:Jeffrey E. Green
affiliation:
name:National Cancer Institute, National Institutes of Health
address:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
name:Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
name:Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
Social Networks {๐}(2)
External Links {๐}(157)
- What is the monthly revenue of https://orcid.org/0000-0003-1201-0954?
- How much does https://trevigen.com/product-category/physiologic-cell-culture/extracellular-matrix-proteins/ pull in monthly?
- How much revenue does https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE112094 generate?
- How much revenue does https://doi.org/10.1097%2FSLA.0000000000001930 bring in?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=27455160's total income per month
- Revenue of http://scholar.google.com/scholar_lookup?&title=Local%20recurrence%20and%20breast%20oncological%20surgery%20in%20young%20women%20with%20breast%20cancer%3A%20The%20POSH%20Observational%20Cohort%20Study&journal=Ann.%20Surg.&doi=10.1097%2FSLA.0000000000001930&volume=266&pages=165-172&publication_year=2017&author=Maishman%2CT
- What's the profit of https://doi.org/10.1016%2Fj.cell.2016.11.037?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=28187288 generate monthly?
- Discover the revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308465
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Emerging%20biological%20principles%20of%20metastasis&journal=Cell&doi=10.1016%2Fj.cell.2016.11.037&volume=168&pages=670-691&publication_year=2017&author=Lambert%2CAW&author=Pattabiraman%2CDR&author=Weinberg%2CRA
- What is the monthly revenue of https://doi.org/10.1038%2Fnrc3793?
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25118602 generate?
- Learn about the earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230700
- Revenue of http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20disseminated%20cancer%20cell%20dormancy%3A%20an%20awakening%20field&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc3793&volume=14&pages=611-622&publication_year=2014&author=Sosa%2CMS&author=Bragado%2CP&author=Aguirre-Ghiso%2CJA
- How much does https://doi.org/10.1038%2Fnrc2256 make?
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17957189
- How much money does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519109 generate?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Models%2C%20mechanisms%20and%20clinical%20evidence%20for%20cancer%20dormancy&journal=Nat.%20Rev.%20Cancer&doi=10.1038%2Fnrc2256&volume=7&pages=834-846&publication_year=2007&author=Aguirre-Ghiso%2CJA have monthly?
- What's the profit of https://doi.org/10.1016%2Fj.ejca.2010.02.027?
- How much cash flow does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20304630 have monthly?
- How much income does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856784 have?
- How much money does http://scholar.google.com/scholar_lookup?&title=Extracellular%20matrix%3A%20a%20gatekeeper%20in%20the%20transition%20from%20dormancy%20to%20metastatic%20growth&journal=Eur.%20J.%20Cancer&doi=10.1016%2Fj.ejca.2010.02.027&volume=46&pages=1181-1188&publication_year=2010&author=Barkan%2CD&author=Green%2CJE&author=Chambers%2CAF generate?
- https://doi.org/10.1083%2Fjcb.201102147's financial summary
- What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22351925?
- How much revenue does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283993 generate?
- How much revenue does http://scholar.google.com/scholar_lookup?&title=The%20extracellular%20matrix%3A%20a%20dynamic%20niche%20in%20cancer%20progression&journal=J.%20Cell%20Biol.&doi=10.1083%2Fjcb.201102147&volume=196&pages=395-406&publication_year=2012&author=Lu%2CP&author=Weaver%2CVM&author=Werb%2CZ generate?
- https://link.springer.com/doi/10.1007/s10555-016-9650-0's revenue stream
- How much does http://scholar.google.com/scholar_lookup?&title=From%20transformation%20to%20metastasis%3A%20deconstructing%20the%20extracellular%20matrix%20in%20breast%20cancer&journal=Cancer%20Metastas.%20Rev.&doi=10.1007%2Fs10555-016-9650-0&volume=35&pages=655-667&publication_year=2016&author=Kaushik%2CS&author=Pickup%2CMW&author=Weaver%2CVM make?
- Revenue of https://doi.org/10.1158%2F0008-5472.CAN-07-6849
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18676848 bring in?
- Income figures for http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561279
- http://scholar.google.com/scholar_lookup?&title=Inhibition%20of%20metastatic%20outgrowth%20from%20single%20dormant%20tumor%20cells%20by%20targeting%20the%20cytoskeleton&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-07-6849&volume=68&pages=6241-6250&publication_year=2008&author=Barkan%2CD's revenue stream
- Revenue of https://doi.org/10.1158%2F0008-5472.CAN-09-2356
- Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20570886
- Financial intake of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436125
- How much income is http://scholar.google.com/scholar_lookup?&title=Metastatic%20growth%20from%20dormant%20cells%20induced%20by%20a%20col-I-enriched%20fibrotic%20environment&journal=Cancer%20Res.&doi=10.1158%2F0008-5472.CAN-09-2356&volume=70&pages=5706-5716&publication_year=2010&author=Barkan%2CD earning monthly?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=An%20in%20vitro%20system%20to%20study%20tumor%20dormancy%20and%20the%20switch%20to%20metastatic%20growth&journal=J.%20Vis.%20Exp.&volume=54&publication_year=2011&author=Barkan%2CD&author=Green%2CJE
- Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2790822
- Earnings of http://scholar.google.com/scholar_lookup?&title=Growth%20regulation%20of%20mouse%20mammary%20tumor%20cells%20in%20collagen%20gel%20cultures%20by%20diffusible%20factors%20produced%20by%20normal%20mammary%20gland%20epithelium%20and%20stromal%20fibroblasts&journal=Cancer%20Res.&volume=49&pages=6091-6097&publication_year=1989&author=Miller%2CFR&author=McEachern%2CD&author=Miller%2CBE
- How much profit does https://doi.org/10.1038%2Fbjc.1992.138 make?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=1586590 generate monthly?
- How profitable is http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977372?
- Monthly income for http://scholar.google.com/scholar_lookup?&title=Sequential%20alteration%20of%20peanut%20agglutinin%20binding-glycoprotein%20expression%20during%20progression%20of%20murine%20mammary%20neoplasia&journal=Br.%20J.%20Cancer&doi=10.1038%2Fbjc.1992.138&volume=65&pages=641-648&publication_year=1992&author=Rak%2CJW&author=McEachern%2CD&author=Miller%2CFR
- How much revenue does https://link.springer.com/doi/10.1007/BF01755879 produce monthly?
- What is the earnings of http://scholar.google.com/scholar_lookup?&title=Mammary%20carcinoma%20cell%20lines%20of%20high%20and%20low%20metastatic%20potential%20differ%20not%20in%20extravasation%20but%20in%20subsequent%20migration%20and%20growth&journal=Clin.%20Exp.%20Metastas.&doi=10.1007%2FBF01755879&volume=12&pages=357-367&publication_year=1994&author=Morris%2CVL?
- What's the income of https://doi.org/10.1172%2FJCI70259?
- Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=24316974
- How much does http://scholar.google.com/scholar_lookup?&title=Combined%20SFK%2FMEK%20inhibition%20prevents%20metastatic%20outgrowth%20of%20dormant%20tumor%20cells&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI70259&volume=124&pages=156-168&publication_year=2014&author=El%20Touny%2CLH bring in each month?
- Get to know what's the income of https://link.springer.com/doi/10.1007/978-1-4614-1445-2_5
- What's http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=23143976's gross income?
- Explore the financials of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651695
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20tumor%20cell%20dormancy%20by%20tissue%20microenvironments%20and%20autophagy&journal=Adv.%20Exp.%20Med.%20Biol.&doi=10.1007%2F978-1-4614-1445-2_5&volume=734&pages=73-89&publication_year=2013&author=Sosa%2CMS&author=Bragado%2CP&author=Debnath%2CJ&author=Aguirre-Ghiso%2CJA?
- How much profit is https://doi.org/10.1038%2Fncb1537 making per month?
- Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17237771
- What's the income of http://scholar.google.com/scholar_lookup?&title=The%20energy%20sensing%20LKB1-AMPK%20pathway%20regulatesp27%28kip1%29%20phosphorylation%20mediating%20the%20decision%20to%20enter%20autophagy%20or%20apoptosis&journal=Nat.%20Cell%20Biol.&doi=10.1038%2Fncb1537&volume=9&pages=218-224&publication_year=2007&author=Liang%2CJ?
- What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=19033662?
- How much profit does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582930 make?
- How much does http://scholar.google.com/scholar_lookup?&title=The%20tumor%20suppressor%20gene%20ARHI%20regulates%20autophagy%20and%20tumor%20dormancy%20in%20human%20ovarian%20cancer%20cells&journal=J.%20Clin.%20Invest.&volume=118&pages=3917-3929&publication_year=2008&author=Lu%2CZ make?
- How much money does https://doi.org/10.1073%2Fpnas.1000248107 make?
- How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2010PNAS..10714333G generate monthly?
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20660757 generate?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922542 generate monthly?
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=Autophagy%20inhibition%20and%20antimalarials%20promote%20cell%20death%20in%20gastrointestinal%20stromal%20tumor%20%28GIST%29&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.1000248107&volume=107&pages=14333-14338&publication_year=2010&author=Gupta%2CA?
- Find out how much https://doi.org/10.1016%2Fj.cell.2011.10.026 earns monthly
- Earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22078875
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Autophagy%3A%20renovation%20of%20cells%20and%20tissues&journal=Cell&doi=10.1016%2Fj.cell.2011.10.026&volume=147&pages=728-741&publication_year=2011&author=Mizushima%2CN&author=Komatsu%2CM?
- See how much https://doi.org/10.4161%2Fauto.4451 makes per month
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17534139?
- Income figures for http://scholar.google.com/scholar_lookup?&title=Dissection%20of%20the%20autophagosome%20maturation%20process%20by%20a%20novel%20reporter%20protein%2C%20tandem%20fluorescent-tagged%20LC3&journal=Autophagy&doi=10.4161%2Fauto.4451&volume=3&pages=452-460&publication_year=2007&author=Kimura%2CS&author=Noda%2CT&author=Yoshimori%2CT
- Get to know https://doi.org/10.1158%2F1078-0432.CCR-10-2634's earnings
- Income figures for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21325294
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075808 pull in?
- Earnings of http://scholar.google.com/scholar_lookup?&title=Principles%20and%20current%20strategies%20for%20targeting%20autophagy%20for%20cancer%20treatment&journal=Clin.%20Cancer%20Res.&doi=10.1158%2F1078-0432.CCR-10-2634&volume=17&pages=654-666&publication_year=2011&author=Amaravadi%2CRK
- What's the financial outcome of https://doi.org/10.1016%2Fj.cell.2016.09.030?
- Check the income stats for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=27768885
- What is the earnings of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114003?
- How much does http://scholar.google.com/scholar_lookup?&title=p62%20in%20cancer%3A%20signaling%20adaptor%20beyond%20autophagy&journal=Cell&doi=10.1016%2Fj.cell.2016.09.030&volume=167&pages=606-609&publication_year=2016&author=Moscat%2CJ&author=Karin%2CM&author=Diaz-Meco%2CMT make?
- How much profit does https://doi.org/10.4161%2Fauto.4600 make?
- Explore the financials of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17611390
- Revenue of http://scholar.google.com/scholar_lookup?&title=How%20to%20interpret%20LC3%20immunoblotting&journal=Autophagy&doi=10.4161%2Fauto.4600&volume=3&pages=542-545&publication_year=2007&author=Mizushima%2CN&author=Yoshimori%2CT
- What's the total monthly financial gain of https://doi.org/10.1089%2Fars.2011.4407?
- Monthly income for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22077334
- How much profit is http://scholar.google.com/scholar_lookup?&title=Mitophagy%3A%20a%20complex%20mechanism%20of%20mitochondrial%20removal&journal=Antioxid.%20Redox%20Signal.&doi=10.1089%2Fars.2011.4407&volume=17&pages=794-802&publication_year=2012&author=Novak%2CI making per month?
- How much does https://doi.org/10.1038%2Fnrm3028 rake in every month?
- Get to know http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21179058's earnings
- What's the monthly income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780047?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20mitophagy&journal=Nat.%20Rev.%20Mol.%20Cell.%20Biol.&doi=10.1038%2Fnrm3028&volume=12&pages=9-14&publication_year=2011&author=Youle%2CRJ&author=Narendra%2CDP have monthly?
- Explore the financials of https://doi.org/10.1080%2F15548627.2015.1063763
- Learn about the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26101826
- How much profit does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590680 make?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Intramembrane%20protease%20PARL%20defines%20a%20negative%20regulator%20of%20PINK1-%20and%20PARK2%2FParkin-dependent%20mitophagy&journal=Autophagy&doi=10.1080%2F15548627.2015.1063763&volume=11&pages=1484-1498&publication_year=2015&author=Meissner%2CC&author=Lorenz%2CH&author=Hehn%2CB&author=Lemberg%2CMK each month?
- Financial intake of https://doi.org/10.1038%2Fcddis.2009.16
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21364619 net monthly?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032505 pull in?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Caspase-mediated%20cleavage%20of%20Beclin-1%20inactivates%20Beclin-1-induced%20autophagy%20and%20enhances%20apoptosis%20by%20promoting%20the%20release%20of%20proapoptotic%20factors%20from%20mitochondria&journal=Cell%20Death%20Dis.&doi=10.1038%2Fcddis.2009.16&volume=1&publication_year=2010&author=Wirawan%2CE make?
- Get to know what's the income of https://doi.org/10.1016%2Fbs.acr.2016.01.005
- How much profit is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=27037750 making per month?
- See how much http://scholar.google.com/scholar_lookup?&title=The%20evolving%2C%20multifaceted%20roles%20of%20autophagy%20in%20cancer&journal=Adv.%20Cancer%20Res.&doi=10.1016%2Fbs.acr.2016.01.005&volume=130&pages=1-53&publication_year=2016&author=Liu%2CJ&author=Debnath%2CJ makes per month
- How much revenue does https://doi.org/10.1038%2Fonc.2016.333 bring in?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=27593926's total income per month
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Autophagy%20in%20cancer%20metastasis&journal=Oncogene&doi=10.1038%2Fonc.2016.333&volume=36&pages=1619-1630&publication_year=2017&author=Mowers%2CEE&author=Sharifi%2CMN&author=Macleod%2CKF
- Discover the revenue of https://doi.org/10.1172%2FJCI73941
- How much money does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=25654549 generate?
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382247's total income per month
- What's the financial intake of http://scholar.google.com/scholar_lookup?&title=The%20role%20for%20autophagy%20in%20cancer&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI73941&volume=125&pages=42-46&publication_year=2015&author=White%2CE?
- What are the earnings of https://doi.org/10.1038%2Fnature17038?
- What's the income generated by http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=2016Natur.529..298M each month?
- What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26791720?
- What's http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029466's gross income?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Metastatic%20colonization%20by%20circulating%20tumour%20cells&journal=Nature&doi=10.1038%2Fnature17038&volume=529&pages=298-306&publication_year=2016&author=Massague%2CJ&author=Obenauf%2CAC generate?
- Explore the financials of https://doi.org/10.1016%2Fj.humpath.2007.09.012
- What is the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18329692?
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=Histopathologic%20factors%20significantly%20associated%20with%20initial%20orga-specific%20metastasis%20by%20invasive%20ductal%20carcinoma%20of%20the%20breast%3A%20a%20prospective%20study&journal=Hum.%20Pathol.&doi=10.1016%2Fj.humpath.2007.09.012&volume=39&pages=681-693&publication_year=2008&author=Hasebe%2CT?
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=22944659?
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630798 net monthly?
- http://scholar.google.com/scholar_lookup?&title=Mitophagy%3A%20mechanisms%2C%20pathophysiological%20roles%2C%20and%20analysis&journal=Biol.%20Chem.&volume=393&pages=547-564&publication_year=2012&author=Ding%2CWX&author=Yin%2CXM income
- How much does https://doi.org/10.1002%2Fjcp.25349 rake in every month?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=26895995's total income per month
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Mitochondria%20and%20mitochondrial%20ROS%20in%20cancer%3A%20novel%20targets%20for%20anticancer%20therapy&journal=J.%20Cell%20Physiol.&doi=10.1002%2Fjcp.25349&volume=231&pages=2570-2581&publication_year=2016&author=Yang%2CY?
- What's the financial outcome of https://doi.org/10.1016%2Fj.critrevonc.2011.01.004?
- What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21288735?
- What's the income generated by http://scholar.google.com/scholar_lookup?&title=Free%20radicals%20in%20breast%20carcinogenesis%2C%20breast%20cancer%20progression%20and%20cancer%20stem%20cells.%20Biological%20bases%20to%20develop%20oxidative-based%20therapies&journal=Crit.%20Rev.%20Oncol.%20Hematol.&doi=10.1016%2Fj.critrevonc.2011.01.004&volume=80&pages=347-368&publication_year=2011&author=Vera-Ramirez%2CL each month?
- Revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11929839
- http://scholar.google.com/scholar_lookup?&title=Persistence%20of%20solitary%20mammary%20carcinoma%20cells%20in%20a%20secondary%20site%3A%20a%20possible%20contributor%20to%20dormancy&journal=Cancer%20Res.&volume=62&pages=2162-2168&publication_year=2002&author=Naumov%2CGN's revenue stream
- What's the revenue for https://doi.org/10.1016%2FS0091-679X%2807%2983023-8?
- Learn how profitable http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17613324 is on a monthly basis
- How much revenue does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658721 produce monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Demystifying%20the%20effects%20of%20a%20three-dimensional%20microenvironment%20in%20tissue%20morphogenesis&journal=Methods%20Cell%20Biol.&doi=10.1016%2FS0091-679X%2807%2983023-8&volume=83&pages=547-583&publication_year=2007&author=Johnson%2CKR&author=Leight%2CJL&author=Weaver%2CVM make?
- https://doi.org/10.1172%2FJCI119590's total income per month
- Learn about the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9259574
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC508247 rake in every month?
- Get to know http://scholar.google.com/scholar_lookup?&title=Adenovector-mediated%20gene%20transfer%20of%20active%20transforming%20growth%20factor-beta1%20induces%20prolonged%20severe%20fibrosis%20in%20rat%20lung&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI119590&volume=100&pages=768-776&publication_year=1997&author=Sime%2CPJ&author=Xing%2CZ&author=Graham%2CFL&author=Csaky%2CKG&author=Gauldie%2CJ's earnings
- Get to know https://citation-needed.springer.com/v2/references/10.1038/s41467-018-04070-6?format=refman&flavour=references's earnings
- Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Laura%20Vera-Ramirez
- What's the revenue for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Laura%20Vera-Ramirez%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Income figures for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Suman%20K.%20Vodnala
- Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Suman%20K.%20Vodnala%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
- Discover the revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ryan%20Nini
- How much income does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ryan%20Nini%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kent%20W.%20Hunter income
- What's https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kent%20W.%20Hunter%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's gross income?
- What are the total earnings of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jeffrey%20E.%20Green?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jeffrey%20E.%20Green%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en net monthly?
- Get to know what's the income of https://static-content.springer.com/esm/art%3A10.1038%2Fs41467-018-04070-6/MediaObjects/41467_2018_4070_MOESM1_ESM.pdf
- How much does http://creativecommons.org/licenses/by/4.0/ gross monthly?
- https://s100.copyright.com/AppDispatchServlet?title=Autophagy%20promotes%20the%20survival%20of%20dormant%20breast%20cancer%20cells%20and%20metastatic%20tumour%20recurrence&author=Laura%20Vera-Ramirez%20et%20al&contentID=10.1038%2Fs41467-018-04070-6©right=The%20Author%28s%29&publication=2041-1723&publicationDate=2018-05-22&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY's revenue stream
- What is the monthly revenue of https://crossmark.crossref.org/dialog/?doi=10.1038/s41467-018-04070-6?
- Get to know what's the income of https://citation-needed.springer.com/v2/references/10.1038/s41467-018-04070-6?format=refman&flavour=citation
- What's the total monthly financial gain of https://doi.org/10.1186/s40779-025-00595-2?
- What's the income generated by https://doi.org/10.1186/s13045-025-01684-4 each month?
- https://doi.org/10.1038/s41556-025-01689-8's financial summary
- How much cash flow does https://doi.org/10.1038/s41392-025-02242-7 have monthly?
- What's the income generated by https://doi.org/10.1007/s12032-025-02607-6 each month?
- What's the financial gain of https://www.protocols.io/?
- How much does https://www.natureindex.com/ earn?
- Learn about the earnings of http://www.naturechina.com
- How much does https://www.natureasia.com/ja-jp pull in monthly?
Analytics and Tracking {๐}
- Google Tag Manager
Libraries {๐}
- Prism.js
- Zoom.js
Emails and Hosting {โ๏ธ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {๐ฆ}
- Crossref