We are analyzing https://link.springer.com/article/10.1007/bf01755879.

Title:
Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth | Clinical & Experimental Metastasis
Description:
We examined the extravasation and subsequent migration and growth of murine mammary tumor cell lines (D2A1 and D2.OR) which differ in their metastatic ability in lung and liver, invasiveness in vitro and expression of the cysteine proteinase cathepsin L. In light of the differences in invasiveness and cathepsin L expression, we hypothesized that during hematogenous metastasis the two cell lines would differ primarily in their ability to extravasate. We used in vivo videomicroscopy of mouse liver and chick embryo chorioallantoic membrane to examine the process and timing of extravasation and subsequent steps in metastasis for these cell lines. In contrast to our expectations, no differences were found between the cell lines in either the timing or mechanism of extravasation, at least 95% of cells having extravasated by 3 days after injection. However, after extravasation, the more metastatic and invasive D2A1 cells showed a greater ability to migrate to sites which favor tumor growth and to replicate to form micrometastases. These studies point to post-extravasation events (migration and growth) as being critical in metastasis formation.
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Keywords {🔍}

google, scholar, metastasis, cell, tumor, cancer, cells, article, extravasation, growth, chambers, mammary, morris, lines, metastatic, migration, access, res, macdonald, invasion, ontario, london, privacy, cookies, content, research, koop, schmidt, ann, groom, murine, liver, weiss, aspects, publish, search, experimental, differ, subsequent, chick, open, exp, department, university, data, information, log, journal, carcinoma, vincent,

Topics {✒️}

month download article/chapter tumor cell invasion motility-proliferation-metabolism interplay paracrine/autocrine growth mechanisms immune-deficient chick embryo murine mammary neoplasia tumor cell instability cell lines cell adhesion proteins robarts research institute full article pdf related subjects favor tumor growth reduces tumor growth high-resolution intravital videomicroscopy privacy choices/manage cookies studying metastasis b16f1 melanoma cells check access semin cancer biol instant access intravascular tumor cells metastatic neoplasms origins b16 amelanotic melanoma a-chip platform chick embryos studied tumor invasion cell sci clin exp metastasis european economic area image-assisted microvessel rabbit ear chamber collagen gel cultures diffusible factors produced chorioallantoic microcirculation stetler-stevenson wg electron microscopic observations experimental metastases subsequent migration conditions privacy policy hall medical publishers electron microscopic study accepting optional cookies cysteine proteinase cathepsin article log dean percy article morris curr opin oncol koop set al post-extravasation events

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Schipper H, Goh CR and Wang TL, 1993, Rethinking cancer: should we control rather than kill?

Schema {🗺️}

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         headline:Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth
         description: We examined the extravasation and subsequent migration and growth of murine mammary tumor cell lines (D2A1 and D2.OR) which differ in their metastatic ability in lung and liver, invasiveness in vitro and expression of the cysteine proteinase cathepsin L. In light of the differences in invasiveness and cathepsin L expression, we hypothesized that during hematogenous metastasis the two cell lines would differ primarily in their ability to extravasate. We used in vivo videomicroscopy of mouse liver and chick embryo chorioallantoic membrane to examine the process and timing of extravasation and subsequent steps in metastasis for these cell lines. In contrast to our expectations, no differences were found between the cell lines in either the timing or mechanism of extravasation, at least 95% of cells having extravasated by 3 days after injection. However, after extravasation, the more metastatic and invasive D2A1 cells showed a greater ability to migrate to sites which favor tumor growth and to replicate to form micrometastases. These studies point to post-extravasation events (migration and growth) as being critical in metastasis formation.
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         dateModified:
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         pageEnd:367
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            chorioallantoic membrane
            extravasation
            liver
            mammary carcinoma lines
            tumor growth
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            Biomedicine
            general
            Oncology
            Hematology
            Surgical Oncology
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      headline:Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth
      description: We examined the extravasation and subsequent migration and growth of murine mammary tumor cell lines (D2A1 and D2.OR) which differ in their metastatic ability in lung and liver, invasiveness in vitro and expression of the cysteine proteinase cathepsin L. In light of the differences in invasiveness and cathepsin L expression, we hypothesized that during hematogenous metastasis the two cell lines would differ primarily in their ability to extravasate. We used in vivo videomicroscopy of mouse liver and chick embryo chorioallantoic membrane to examine the process and timing of extravasation and subsequent steps in metastasis for these cell lines. In contrast to our expectations, no differences were found between the cell lines in either the timing or mechanism of extravasation, at least 95% of cells having extravasated by 3 days after injection. However, after extravasation, the more metastatic and invasive D2A1 cells showed a greater ability to migrate to sites which favor tumor growth and to replicate to form micrometastases. These studies point to post-extravasation events (migration and growth) as being critical in metastasis formation.
      datePublished:
      dateModified:
      pageStart:357
      pageEnd:367
      sameAs:https://doi.org/10.1007/BF01755879
      keywords:
         cancer cell migration
         chorioallantoic membrane
         extravasation
         liver
         mammary carcinoma lines
         tumor growth
         Cancer Research
         Biomedicine
         general
         Oncology
         Hematology
         Surgical Oncology
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      name:Department of Medical Biophysics, University of Western Ontario, London
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      name:Department of Pathology, University of Guelph, Guelph
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      name:John P. Robarts Research Institute, London, Canada
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