NATURE . COM {
}
Title:
Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer | Oncogene
Description:
Epithelial–mesenchymal transition (EMT) is an initiating event in tumor cell invasion and metastasis. It has been shown to occur in resistance to a range of cancer therapies, including tamoxifen. MicroRNAs (miRNAs) have been associated with EMT as well as resistance to standard therapies. To investigate the role of miRNAs in the development of resistance to tamoxifen as well as accompanying EMT-like properties, we established a tamoxifen-resistant (TamR) model by continually exposing MCF-7 breast cancer cells to tamoxifen. In addition to the molecular changes known to be involved in acquired tamoxifen resistance, TamR cells displayed mesenchymal features and had increased invasiveness. Genome-wide miRNA microarray analysis revealed that miRNA-375 was among the top downregulated miRNAs in resistant cells. Re-expression of miR-375 was sufficient to sensitize TamR cells to tamoxifen and partly reversed EMT. A combination of mRNA profiling, bioinformatics analysis and experimental validation identified metadherin (MTDH) as a direct target of miR-375. Knockdown of MTDH partially phenocopied the effects of miR-375 on the sensitivity to tamoxifen and the reversal of EMT. We observed an inverse correlation between the expression of miR-375 and its target MTDH in primary breast cancer samples, implying the pathological relevance of targeting. Finally, tamoxifen-treated patients with higher expression of MTDH had a shorter disease-free survival and higher risk of relapse. As most cancer-related deaths occur because of resistance to standard therapies and metastasis, re-expression of miR-375 or targeting MTDH might serve as potential therapeutic approaches for the treatment of TamR breast cancer.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Science
- Education
- Health & Fitness
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌠 Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.
Keywords {🔍}
cells, mirna, tamr, cancer, tamoxifen, mtdh, expression, cell, breast, resistance, article, figure, mcf, google, scholar, cas, mirnas, emt, invasion, data, patients, shown, results, properties, compared, epithelial, emtlike, mesenchymal, genes, luciferase, assay, target, lines, significantly, supplementary, reduced, nature, reexpression, ecadherin, effects, higher, potential, viability, usa, analysis, mrna, direct, targeting, survival, line,
Topics {✒️}
nature portfolio privacy policy nature 1978 nature advertising gov/index er/her2-positive breast cancer social media translational research sciences high erbb2/her2-expressing patients 0/ reprints mirna-overexpression vectors pcmv-mirs epithelial–mesenchymal transition epithelial-mesenchymal transition creative commons attribution-noncommercial pharmaceutical research kaplan–meier survival curves tight cell–cell junctions total dna content anti-e-cadherin antibody poor-prognosis breast cancer hrp-conjugated secondary antibodies tight cell–cell contacts cancer-related deaths occur cancer-relevant deaths arise received tamoxifen monotherapy hoffmann-la roche limited luciferase-based viability assay hormone receptor-positive patients e-cadherin predominantly localized normalize qrt–pcr data benjamini–hochberg adjusted p author correspondence large gene-targeting spectrum review article epithelial poorer disease-free survival differentially expressed micrornas research ec50 dose-response analysis qrt–pcr data validation shorter disease-free survival dose-response curves showed poorer relapse-free survival hek-293ft cell line downregulating e-cadherin expression anchorage-independent growth capacity therapeutic strategies potential therapeutic approaches qrt–pcr data show absolute log fold-change
Schema {🗺️}
WebPage:
mainEntity:
headline:Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer
description:Epithelialâmesenchymal transition (EMT) is an initiating event in tumor cell invasion and metastasis. It has been shown to occur in resistance to a range of cancer therapies, including tamoxifen. MicroRNAs (miRNAs) have been associated with EMT as well as resistance to standard therapies. To investigate the role of miRNAs in the development of resistance to tamoxifen as well as accompanying EMT-like properties, we established a tamoxifen-resistant (TamR) model by continually exposing MCF-7 breast cancer cells to tamoxifen. In addition to the molecular changes known to be involved in acquired tamoxifen resistance, TamR cells displayed mesenchymal features and had increased invasiveness. Genome-wide miRNA microarray analysis revealed that miRNA-375 was among the top downregulated miRNAs in resistant cells. Re-expression of miR-375 was sufficient to sensitize TamR cells to tamoxifen and partly reversed EMT. A combination of mRNA profiling, bioinformatics analysis and experimental validation identified metadherin (MTDH) as a direct target of miR-375. Knockdown of MTDH partially phenocopied the effects of miR-375 on the sensitivity to tamoxifen and the reversal of EMT. We observed an inverse correlation between the expression of miR-375 and its target MTDH in primary breast cancer samples, implying the pathological relevance of targeting. Finally, tamoxifen-treated patients with higher expression of MTDH had a shorter disease-free survival and higher risk of relapse. As most cancer-related deaths occur because of resistance to standard therapies and metastasis, re-expression of miR-375 or targeting MTDH might serve as potential therapeutic approaches for the treatment of TamR breast cancer.
datePublished:2012-04-16T00:00:00Z
dateModified:2012-04-16T00:00:00Z
pageStart:1173
pageEnd:1182
sameAs:https://doi.org/10.1038/onc.2012.128
keywords:
Breast cancer
Cancer therapeutic resistance
Epithelialâmesenchymal transition
miRNAs
microRNAs
tamoxifen resistance
epithelialâmesenchymal transition
breast cancer
metadherin
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig6_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:32
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:A Ward
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:A Balwierz
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:J D Zhang
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:M Küblbeck
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Y Pawitan
affiliation:
name:Karolinska Institute
address:
name:Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
type:PostalAddress
type:Organization
type:Person
name:T Hielscher
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:S Wiemann
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Ã Sahin
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer
description:Epithelialâmesenchymal transition (EMT) is an initiating event in tumor cell invasion and metastasis. It has been shown to occur in resistance to a range of cancer therapies, including tamoxifen. MicroRNAs (miRNAs) have been associated with EMT as well as resistance to standard therapies. To investigate the role of miRNAs in the development of resistance to tamoxifen as well as accompanying EMT-like properties, we established a tamoxifen-resistant (TamR) model by continually exposing MCF-7 breast cancer cells to tamoxifen. In addition to the molecular changes known to be involved in acquired tamoxifen resistance, TamR cells displayed mesenchymal features and had increased invasiveness. Genome-wide miRNA microarray analysis revealed that miRNA-375 was among the top downregulated miRNAs in resistant cells. Re-expression of miR-375 was sufficient to sensitize TamR cells to tamoxifen and partly reversed EMT. A combination of mRNA profiling, bioinformatics analysis and experimental validation identified metadherin (MTDH) as a direct target of miR-375. Knockdown of MTDH partially phenocopied the effects of miR-375 on the sensitivity to tamoxifen and the reversal of EMT. We observed an inverse correlation between the expression of miR-375 and its target MTDH in primary breast cancer samples, implying the pathological relevance of targeting. Finally, tamoxifen-treated patients with higher expression of MTDH had a shorter disease-free survival and higher risk of relapse. As most cancer-related deaths occur because of resistance to standard therapies and metastasis, re-expression of miR-375 or targeting MTDH might serve as potential therapeutic approaches for the treatment of TamR breast cancer.
datePublished:2012-04-16T00:00:00Z
dateModified:2012-04-16T00:00:00Z
pageStart:1173
pageEnd:1182
sameAs:https://doi.org/10.1038/onc.2012.128
keywords:
Breast cancer
Cancer therapeutic resistance
Epithelialâmesenchymal transition
miRNAs
microRNAs
tamoxifen resistance
epithelialâmesenchymal transition
breast cancer
metadherin
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig2_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig5_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_Article_BFonc2012128_Fig6_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:32
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:A Ward
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:A Balwierz
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:J D Zhang
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:M Küblbeck
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Y Pawitan
affiliation:
name:Karolinska Institute
address:
name:Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
type:PostalAddress
type:Organization
type:Person
name:T Hielscher
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:S Wiemann
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
type:Person
name:Ã Sahin
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:32
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
name:Karolinska Institute
address:
name:Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
type:PostalAddress
name:German Cancer Research Center (DKFZ)
address:
name:Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:A Ward
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
name:A Balwierz
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
name:J D Zhang
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
name:M Küblbeck
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
name:Y Pawitan
affiliation:
name:Karolinska Institute
address:
name:Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
type:PostalAddress
type:Organization
name:T Hielscher
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
name:S Wiemann
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
name:Ã Sahin
affiliation:
name:German Cancer Research Center (DKFZ)
address:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
name:Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
name:Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
name:Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
External Links {🔗}(100)
- What's the total monthly financial gain of http://dtp.nci.nih.gov/index.html?
- What's the total monthly financial gain of https://doi.org/10.1038%2Fnrc2193?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Modelling%20breast%20cancer%3A%20one%20size%20does%20not%20fit%20all&journal=Nat%20Rev%20Cancer&doi=10.1038%2Fnrc2193&volume=7&pages=659-672&publication_year=2007&author=Vargo-Gogola%2CT&author=Rosen%2CJM
- How much does https://doi.org/10.1210%2Fedrv-11-4-578 pull in?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Endocrine%20pharmacology%20of%20antiestrogens%20as%20antitumor%20agents&journal=Endocr%20Rev&doi=10.1210%2Fedrv-11-4-578&volume=11&pages=578-610&publication_year=1990&author=Jordan%2CVC&author=Murphy%2CCS
- Check the income stats for https://link.springer.com/doi/10.1007/BF01806018
- What are the earnings of http://scholar.google.com/scholar_lookup?&title=Antiestrogen%20action%20in%20breast%20cancer%20cells%3A%20modulation%20of%20proliferation%20and%20protein%20synthesis%2C%20and%20interaction%20with%20estrogen%20receptors%20and%20additional%20antiestrogen%20binding%20sites&journal=Breast%20Cancer%20Res%20Treat&doi=10.1007%2FBF01806018&volume=5&pages=231-543&publication_year=1985&author=Katzenellenbogen%2CBS&author=Miller%2CMA&author=Mullick%2CA&author=Sheen%2CYY?
- What's the revenue for https://doi.org/10.1677%2Ferc.1.00776?
- How much does http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20tamoxifen%20resistance&journal=Endocr%20Relat%20Cancer.&doi=10.1677%2Ferc.1.00776&volume=11&pages=643-658&publication_year=2004&author=Ring%2CA&author=Dowsett%2CM generate monthly?
- How much profit does https://doi.org/10.1016%2Fj.cell.2009.11.007 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=Epithelial-mesenchymal%20transitions%20in%20development%20and%20disease&journal=Cell&doi=10.1016%2Fj.cell.2009.11.007&volume=139&pages=871-890&publication_year=2009&author=Thiery%2CJP&author=Acloque%2CH&author=Huang%2CRY&author=Nieto%2CMA gross monthly?
- Learn about the earnings of https://doi.org/10.1038%2Fnrc2620
- How much does http://scholar.google.com/scholar_lookup?&title=Transitions%20between%20epithelial%20and%20mesenchymal%20states%3A%20acquisition%20of%20malignant%20and%20stem%20cell%20traits&journal=Nat%20Rev%20Cancer&doi=10.1038%2Fnrc2620&volume=9&pages=265-273&publication_year=2009&author=Polyak%2CK&author=Weinberg%2CRA generate monthly?
- Check the income stats for https://doi.org/10.1074%2Fjbc.M804612200
- What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=MicroRNA-221%2F222%20confers%20tamoxifen%20resistance%20in%20breast%20cancer%20by%20targeting%20p27Kip1&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.M804612200&volume=283&pages=29897-29903&publication_year=2008&author=Miller%2CTE&author=Ghoshal%2CK&author=Ramaswamy%2CB&author=Roy%2CS&author=Datta%2CJ&author=Shapiro%2CCL?
- What's the financial gain of https://doi.org/10.1038%2Fncb1722?
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=The%20miR-200%20family%20and%20miR-205%20regulate%20epithelial%20to%20mesenchymal%20transition%20by%20targeting%20ZEB1%20and%20SIP1&journal=Nat%20Cell%20Biol&doi=10.1038%2Fncb1722&volume=10&pages=593-601&publication_year=2008&author=Gregory%2CPA&author=Bert%2CAG&author=Paterson%2CEL&author=Barry%2CSC&author=Tsykin%2CA&author=Farshid%2CG
- Revenue of https://doi.org/10.1158%2F1078-0432.CCR-0433-03
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=Long-term%20exposure%20to%20tamoxifen%20induces%20hypersensitivity%20to%20estradiol&journal=Clin%20Cancer%20Res&doi=10.1158%2F1078-0432.CCR-0433-03&volume=10&pages=1530-1534&publication_year=2004&author=Berstein%2CLM&author=Wang%2CJP&author=Zheng%2CH&author=Yue%2CW&author=Conaway%2CM&author=Santen%2CRJ
- Find out how much https://doi.org/10.1093%2Fjnci%2Fdjh166 earns monthly
- How much revenue does http://scholar.google.com/scholar_lookup?&title=Mechanisms%20of%20tamoxifen%20resistance%3A%20increased%20estrogen%20receptor-HER2%2Fneu%20cross-talk%20in%20ER%2FHER2-positive%20breast%20cancer&journal=J%20Natl%20Cancer%20Inst&doi=10.1093%2Fjnci%2Fdjh166&volume=96&pages=926-935&publication_year=2004&author=Shou%2CJ&author=Massarweh%2CS&author=Osborne%2CCK&author=Wakeling%2CAE&author=Ali%2CS&author=Weiss%2CH generate?
- How much profit is https://link.springer.com/doi/10.1007/s10549-005-9120-9 making per month?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Elevated%20Src%20activity%20promotes%20cellular%20invasion%20and%20motility%20in%20tamoxifen%20resistant%20breast%20cancer%20cells&journal=Breast%20Cancer%20Res%20Treat&doi=10.1007%2Fs10549-005-9120-9&volume=97&pages=263-274&publication_year=2006&author=Hiscox%2CS&author=Morgan%2CL&author=Green%2CTP&author=Barrow%2CD&author=Gee%2CJ&author=Nicholson%2CRI?
- How much revenue does https://doi.org/10.1073%2Fpnas.160016897 bring in?
- Check the income stats for http://scholar.google.com/scholar_lookup?&title=Down-regulation%20of%20p21WAF1%2FCIP1%20or%20p27Kip1%20abrogates%20antiestrogen-mediated%20cell%20cycle%20arrest%20in%20human%20breast%20cancer%20cells&journal=Proc%20Natl%20Acad%20Sci%20USA.&doi=10.1073%2Fpnas.160016897&volume=97&pages=9042-9046&publication_year=2000&author=Cariou%2CS&author=Donovan%2CJC&author=Flanagan%2CWM&author=Milic%2CA&author=Bhattacharya%2CN&author=Slingerland%2CJM
- How much does https://doi.org/10.1038%2F273345a0 earn?
- Get to know http://scholar.google.com/scholar_lookup?&title=Role%20of%20cell%20shape%20in%20growth%20control&journal=Nature&doi=10.1038%2F273345a0&volume=273&pages=345-349&publication_year=1978&author=Folkman%2CJ&author=Moscona%2CA's earnings
- What's the profit of https://doi.org/10.1158%2F0008-5472.CAN-10-1318?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Epigenetically%20deregulated%20microRNA-375%20is%20involved%20in%20a%20positive%20feedback%20loop%20with%20estrogen%20receptor%20alpha%20in%20breast%20cancer%20cells&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-10-1318&volume=70&pages=9175-9184&publication_year=2010&author=de%20Souza%20Rocha%20Simonini%2CP&author=Breiling%2CA&author=Gupta%2CN&author=Malekpour%2CM&author=Youns%2CM&author=Omranipour%2CR?
- How much does https://doi.org/10.1016%2Fj.febslet.2011.06.025 pull in monthly?
- Get to know http://scholar.google.com/scholar_lookup?&title=Epigenetic%20regulation%20of%20microRNA-375%20and%20its%20role%20in%20melanoma%20development%20in%20humans&journal=FEBS%20Lett&doi=10.1016%2Fj.febslet.2011.06.025&volume=585&pages=2467-2476&publication_year=2011&author=Mazar%2CJ&author=DeBlasio%2CD&author=Govindarajan%2CSS&author=Zhang%2CS&author=Perera%2CRJ's earnings
- What's the total monthly financial gain of https://link.springer.com/doi/10.1007/s10585-008-9170-6?
- How much does http://scholar.google.com/scholar_lookup?&title=Epithelial%20mesenchymal%20transition%20traits%20in%20human%20breast%20cancer%20cell%20lines&journal=Clin%20Exp%20Metastasis&doi=10.1007%2Fs10585-008-9170-6&volume=25&pages=629-642&publication_year=2008&author=Blick%2CT&author=Widodo%2CE&author=Hugo%2CH&author=Waltham%2CM&author=Lenburg%2CME&author=Neve%2CRM rake in every month?
- Discover the revenue of https://doi.org/10.1016%2Fj.ccr.2006.10.008
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=A%20collection%20of%20breast%20cancer%20cell%20lines%20for%20the%20study%20of%20functionally%20distinct%20cancer%20subtypes&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2006.10.008&volume=10&pages=515-527&publication_year=2006&author=Neve%2CRM&author=Chin%2CK&author=Fridlyand%2CJ&author=Yeh%2CJ&author=Baehner%2CFL&author=Fevr%2CT?
- Learn how profitable https://doi.org/10.1101%2Fgad.1640608 is on a monthly basis
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=The%20miR-200%20family%20determines%20the%20epithelial%20phenotype%20of%20cancer%20cells%20by%20targeting%20the%20E-cadherin%20repressors%20ZEB1%20and%20ZEB2&journal=Genes%20Dev&doi=10.1101%2Fgad.1640608&volume=22&pages=894-907&publication_year=2008&author=Park%2CSM&author=Gaur%2CAB&author=Lengyel%2CE&author=Peter%2CME?
- How much profit does https://doi.org/10.1016%2Fj.ccr.2008.11.013 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=MTDH%20activation%20by%208q22%20genomic%20gain%20promotes%20chemoresistance%20and%20metastasis%20of%20poor-prognosis%20breast%20cancer&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2008.11.013&volume=15&pages=9-20&publication_year=2009&author=Hu%2CG&author=Chong%2CRA&author=Yang%2CQ&author=Wei%2CY&author=Blanco%2CMA&author=Li%2CF bring in each month?
- How much revenue does https://doi.org/10.1038%2Fonc.2011.223 generate?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Tamoxifen%20downregulation%20of%20miR-451%20increases%2014-3-3zeta%20and%20promotes%20breast%20cancer%20cell%20survival%20and%20endocrine%20resistance&journal=Oncogene&doi=10.1038%2Fonc.2011.223&volume=31&pages=39-47&publication_year=2012&author=Bergamaschi%2CA&author=Katzenellenbogen%2CBS?
- What's the financial gain of https://doi.org/10.1111%2Fj.1349-7006.2009.01260.x?
- How much money does http://scholar.google.com/scholar_lookup?&title=Involvement%20of%20Pin1%20induction%20in%20epithelial-mesenchymal%20transition%20of%20tamoxifen-resistant%20breast%20cancer%20cells&journal=Cancer%20Sci&doi=10.1111%2Fj.1349-7006.2009.01260.x&volume=100&pages=1834-1841&publication_year=2009&author=Kim%2CMR&author=Choi%2CHK&author=Cho%2CKB&author=Kim%2CHS&author=Kang%2CKW generate?
- What's the monthly money flow for https://doi.org/10.1038%2Fsj.onc.1208429?
- See how much http://scholar.google.com/scholar_lookup?&title=DeltaEF1%20is%20a%20transcriptional%20repressor%20of%20E-cadherin%20and%20regulates%20epithelial%20plasticity%20in%20breast%20cancer%20cells&journal=Oncogene&doi=10.1038%2Fsj.onc.1208429&volume=24&pages=2375-2385&publication_year=2005&author=Eger%2CA&author=Aigner%2CK&author=Sonderegger%2CS&author=Dampier%2CB&author=Oehler%2CS&author=Schreiber%2CM makes per month
- Learn about the earnings of https://doi.org/10.1002%2Fijc.21355
- What's the profit of http://scholar.google.com/scholar_lookup?&title=Tamoxifen%20resistance%20in%20MCF7%20cells%20promotes%20EMT-like%20behaviour%20and%20involves%20modulation%20of%20beta-catenin%20phosphorylation&journal=Int%20J%20Cancer&doi=10.1002%2Fijc.21355&volume=118&pages=290-301&publication_year=2006&author=Hiscox%2CS&author=Jiang%2CWG&author=Obermeier%2CK&author=Taylor%2CK&author=Morgan%2CL&author=Burmi%2CR?
- What's the financial gain of https://doi.org/10.1158%2F0008-5472.CAN-09-1298?
- How much income is http://scholar.google.com/scholar_lookup?&title=Up-regulation%20of%20miR-200%20and%20let-7%20by%20natural%20agents%20leads%20to%20the%20reversal%20of%20epithelial-to-mesenchymal%20transition%20in%20gemcitabine-resistant%20pancreatic%20cancer%20cells&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-09-1298&volume=69&pages=6704-6712&publication_year=2009&author=Li%2CY&author=VandenBoom%2CTG&author=Kong%2CD&author=Wang%2CZ&author=Ali%2CS&author=Philip%2CPA earning monthly?
- How much money does https://doi.org/10.1038%2Fonc.2011.263 generate?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=MiR-200b%20and%20miR-15b%20regulate%20chemotherapy-induced%20epithelial-mesenchymal%20transition%20in%20human%20tongue%20cancer%20cells%20by%20targeting%20BMI1&journal=Oncogene&doi=10.1038%2Fonc.2011.263&volume=31&pages=432-445&publication_year=2012&author=Sun%2CL&author=Yao%2CY&author=Liu%2CB&author=Lin%2CZ&author=Lin%2CL&author=Yang%2CM?
- https://doi.org/10.1158%2F0008-5472.CAN-09-2777's total income per month
- Profit of http://scholar.google.com/scholar_lookup?&title=MicroRNA-375%20is%20downregulated%20in%20gastric%20carcinomas%20and%20regulates%20cell%20survival%20by%20targeting%20PDK1%20and%2014-3-3zeta&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-09-2777&volume=70&pages=2339-2349&publication_year=2010&author=Tsukamoto%2CY&author=Nakada%2CC&author=Noguchi%2CT&author=Tanigawa%2CM&author=Nguyen%2CLT&author=Uchida%2CT
- How much profit does https://doi.org/10.1002%2Fhep.22256 make?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=MicroRNA%20profiling%20in%20hepatocellular%20tumors%20is%20associated%20with%20clinical%20features%20and%20oncogene%2Ftumor%20suppressor%20gene%20mutations&journal=Hepatology&doi=10.1002%2Fhep.22256&volume=47&pages=1955-1963&publication_year=2008&author=Ladeiro%2CY&author=Couchy%2CG&author=Balabaud%2CC&author=Bioulac-Sage%2CP&author=Pelletier%2CL&author=Rebouissou%2CS?
- How much does https://doi.org/10.1136%2Fgutjnl-2011-300178 earn?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=MicroRNA-375%20inhibits%20tumour%20growth%20and%20metastasis%20in%20oesophageal%20squamous%20cell%20carcinoma%20through%20repressing%20insulin-like%20growth%20factor%201%20receptor&journal=Gut&doi=10.1136%2Fgutjnl-2011-300178&volume=61&pages=33-42&publication_year=2012&author=Kong%2CKL&author=Kwong%2CDL&author=Chan%2CTH&author=Law%2CSY&author=Chen%2CL&author=Li%2CY
- What's https://doi.org/10.1111%2Fj.1349-7006.2011.01919.x's gross income?
- http://scholar.google.com/scholar_lookup?&title=Metadherin%20enhances%20the%20invasiveness%20of%20breast%20cancer%20cells%20by%20inducing%20epithelial%20to%20mesenchymal%20transition&journal=Cancer%20Sci&doi=10.1111%2Fj.1349-7006.2011.01919.x&volume=102&pages=1151-1157&publication_year=2011&author=Li%2CX&author=Kong%2CX&author=Huo%2CQ&author=Guo%2CH&author=Yan%2CS&author=Yuan%2CC's total income per month
- How much income is https://doi.org/10.1038%2Fonc.2010.201 earning monthly?
- How much money does http://scholar.google.com/scholar_lookup?&title=miR-200bc%2F429%20cluster%20targets%20PLC%CE%B31%20and%20differentially%20regulates%20proliferation%20and%20EGF-driven%20invasion%20than%20miR-200a%2F141%20in%20breast%20cancer&journal=Oncogene&doi=10.1038%2Fonc.2010.201&volume=29&issue=30&pages=4297-4306&publication_year=2010&author=Uhlmann%2CS&author=Zhang%2CJ%20D&author=Schw%C3%A4ger%2CA&author=Mannsperger%2CH&author=Riazalhosseini%2CY&author=Burmester%2CS&author=Ward%2CA&author=Korf%2CU&author=Wiemann%2CS&author=Sahin%2C%C3%96 make?
- https://link.springer.com/doi/10.1186/1752-0509-3-1's total income per month
- How much does http://scholar.google.com/scholar_lookup?&title=Modeling%20ERBB%20receptor-regulated%20G1%2FS%20transition%20to%20find%20novel%20targets%20for%20de%20novo%20trastuzumab%20resistance&journal=BMC%20Syst%20Biol&doi=10.1186%2F1752-0509-3-1&volume=3&publication_year=2009&author=Sahin%2CO&author=Frohlich%2CH&author=Lobke%2CC&author=Korf%2CU&author=Burmester%2CS&author=Majety%2CM rake in every month?
- Explore the financials of https://doi.org/10.1371%2Fjournal.pone.0016915
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=miRNA-mRNA%20integrated%20analysis%20reveals%20roles%20for%20miRNAs%20in%20primary%20breast%20tumors&journal=PLoS%20One&doi=10.1371%2Fjournal.pone.0016915&volume=6&publication_year=2011&author=Enerly%2CE&author=Steinfeld%2CI&author=Kleivi%2CK&author=Leivonen%2CSK&author=Aure%2CMR&author=Russnes%2CHG
- How much income does https://doi.org/10.1158%2F0008-5472.CAN-11-0489 have?
- http://scholar.google.com/scholar_lookup?&title=microRNA-associated%20progression%20pathways%20and%20potential%20therapeutic%20targets%20identified%20by%20integrated%20mRNA%20and%20microRNA%20expression%20profiling%20in%20breast%20cancer&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-11-0489&volume=71&pages=5635-5645&publication_year=2011&author=Buffa%2CFM&author=Camps%2CC&author=Winchester%2CL&author=Snell%2CCE&author=Gee%2CHE&author=Sheldon%2CH's revenue stream
- How much profit does https://doi.org/10.1016%2Fj.ccr.2004.05.015 make?
- Get to know http://scholar.google.com/scholar_lookup?&title=A%20two-gene%20expression%20ratio%20predicts%20clinical%20outcome%20in%20breast%20cancer%20patients%20treated%20with%20tamoxifen&journal=Cancer%20Cell&doi=10.1016%2Fj.ccr.2004.05.015&volume=5&pages=607-616&publication_year=2004&author=Ma%2CXJ&author=Wang%2CZ&author=Ryan%2CPD&author=Isakoff%2CSJ&author=Barmettler%2CA&author=Fuller%2CA's earnings
- See how much https://link.springer.com/doi/10.1186/bcr1325 makes per month
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Gene%20expression%20profiling%20spares%20early%20breast%20cancer%20patients%20from%20adjuvant%20therapy%3A%20derived%20and%20validated%20in%20two%20population-based%20cohorts&journal=Breast%20Cancer%20Res&doi=10.1186%2Fbcr1325&volume=7&pages=R953-R964&publication_year=2005&author=Pawitan%2CY&author=Bjohle%2CJ&author=Amler%2CL&author=Borg%2CAL&author=Egyhazi%2CS&author=Hall%2CP
- How much income does https://citation-needed.springer.com/v2/references/10.1038/onc.2012.128?format=refman&flavour=references have?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=A%20Ward bring in?
- https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22A%20Ward%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en income
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=A%20Balwierz generate?
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22A%20Balwierz%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- What's the monthly money flow for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=J%20D%20Zhang?
- How much income is https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22J%20D%20Zhang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en earning monthly?
- What's https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=M%20K%C3%BCblbeck's gross income?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22M%20K%C3%BCblbeck%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in each month?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y%20Pawitan gross monthly?
- Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y%20Pawitan%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much money does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=T%20Hielscher make?
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22T%20Hielscher%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en pull in monthly?
- What is the monthly revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=S%20Wiemann?
- What's the total monthly financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22S%20Wiemann%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- What's the financial outcome of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=%C3%96%20Sahin?
- Discover the revenue of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22%C3%96%20Sahin%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much money does https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2012.128/MediaObjects/41388_2013_BFonc2012128_MOESM13_ESM.doc generate?
- How much does https://s100.copyright.com/AppDispatchServlet?title=Re-expression%20of%20microRNA-375%20reverses%20both%20tamoxifen%20resistance%20and%20accompanying%20EMT-like%20properties%20in%20breast%20cancer&author=A%20Ward%20et%20al&contentID=10.1038%2Fonc.2012.128©right=The%20Author%28s%29&publication=0950-9232&publicationDate=2012-04-16&publisherName=SpringerNature&orderBeanReset=true&oa=CC%20BY-NC-ND earn?
- What's the profit of https://citation-needed.springer.com/v2/references/10.1038/onc.2012.128?format=refman&flavour=citation?
- What's the total monthly financial gain of https://doi.org/10.1007/s12094-023-03189-3?
- Income figures for https://doi.org/10.1007/s11033-022-07553-4
- Get to know what's the income of https://doi.org/10.1007/s00428-021-03238-8
- How much revenue does https://doi.org/10.1038/s41389-021-00309-y generate?
- How much does https://doi.org/10.1007/s00109-021-02136-5 bring in each month?
- What's https://www.protocols.io/'s gross income?
- How much revenue does https://www.natureindex.com/ bring in?
- How much does http://www.naturechina.com pull in?
- What's the total monthly financial gain of https://www.natureasia.com/ja-jp?
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Prism.js
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {📦}
- Crossref