We are analyzing https://link.springer.com/article/10.1007/s10585-008-9170-6.

Title:
Epithelial mesenchymal transition traits in human breast cancer cell lines | Clinical & Experimental Metastasis
Description:
Epithelial mesenchymal transition (EMT) has long been associated with breast cancer cell invasiveness and evidence of EMT processes in clinical samples is growing rapidly. Genome-wide transcriptional profiling of increasingly larger numbers of human breast cancer (HBC) cell lines have confirmed the existence of a subgroup of cell lines (termed Basal B/Mesenchymal) with enhanced invasive properties and a predominantly mesenchymal gene expression signature, distinct from subgroups with predominantly luminal (termed Luminal) or mixed basal/luminal (termed Basal A) features (Neve et al Cancer Cell 2006). Studies providing molecular and cellular analyses of EMT features in these cell lines are summarised, and the expression levels of EMT-associated factors in these cell lines are analysed. Recent clinical studies supporting the presence of EMT-like changes in vivo are summarised. Human breast cancer cell lines with mesenchymal properties continue to hold out the promise of directing us towards key mechanisms at play in the metastatic dissemination of breast cancer.
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Keywords {🔍}

google, scholar, pubmed, article, cas, cancer, breast, cell, transition, cells, epithelial, human, res, carcinoma, expression, mesenchymal, thompson, lines, epithelialmesenchymal, metastasis, biol, gene, mammary, growth, progression, snail, research, factor, mol, transitions, newgreen, ecadherin, clin, metastatic, stem, receptor, tumor, epithelialtomesenchymal, oncogene, invasion, vimentin, waltham, emt, access, ackland, slug, twist, protein, privacy, cookies,

Topics {✒️}

upregulated mt1-mmp/timp-2 axis tsu-pr1-b1/b2 model month download article/chapter human breast cancer-observations e-cadherin transcriptional downregulation zinc-finger protein helix-loop-helix motif k-atpase beta1-subunit genome-wide transcriptional profiling e-cadherin preserved tumors confers epithelial-mesenchymal transition stem cell characteristics contract de-ac03-76sf00098 prostate cell lines n-cadherin promotes motility epithelial-mesenchymal cell transformation growth factor receptor mammary epithelial cells human breast cancer mesenchymal transition mediated mixed basal/luminal breast cancer cells full article pdf differentiated human breast oncoprotein beta-catenin human breast tumours homotypic cell adhesion nuclear factor-{kappa} mammary gland regeneration pancreatic cancer cells human aromatase gene constitutively active type invasive breast cancer privacy choices/manage cookies e-cadherin expression selectively inhibits growth tumor cell plasticity m14 melanoma cells epithelial-mesenchymal transition epithelial mesenchymal transition human cancer progression hepatocellular carcinoma metastasis transcription factor zeb1 army medical research tumor suppressor gene epithelial-mesenchymal transitions epithelial mesenchymal transitions mesenchymal––epithelial transitions mesenchymal—epithelial transitions transitional cell carcinoma

Questions {❓}

Korsching E, Packeisen J, Liedtke C et al (2005) The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?
Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
Thompson EW, Newgreen DF, Tarin D (2005) Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition?

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