
NATURE . COM {
}
Title:
Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation | Oncogene
Description:
The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt protein stability regulation remains unclear. In this study, we showed a strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 in multiple cancer types (P<0.0001). Akt-pS473 status combined with Pin1 expression levels predicted a poorer prognosis than did either one alone in patients with breast cancer (P=0.0052). We further showed that Pin1 regulated Akt stability and phosphorylation on S473 through the phosphorylated Thr-Pro motifs of Akt. These motifs are conserved evolutionary and are required for the maintenance of Akt stability and its interaction with Pin1. In addition, repressing Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockingdown compromised its ability to protect Akt from degradation. Our results show how Akt protein stability is regulated by the peptidyl-prolyl cis/trans isomerase Pin1 and highlight the importance of this oncogenic network in human disease pathogenesis.
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {π}
- Education
- Health & Fitness
- Telecommunications
Content Management System {π}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of nature.com audience?
π Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,797,153 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {πΈ}
Display Ads {π―}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {π°}
Display Ads {π―}
$539,300 per month
Our calculations suggest that Nature.com earns between $359,538 and $988,730 monthly online from display advertisements.
Keywords {π}
article, pubmed, cas, google, scholar, cancer, akt, pin, nature, protein, kinase, cell, isomerase, phosphorylation, zhou, access, oncogene, breast, central, stability, human, mol, university, regulation, department, content, activation, liao, usa, center, supplementary, cookies, information, yang, chen, hung, expression, prolyl, tsichlis, privacy, peptidylprolyl, cistrans, pkbakt, role, multiple, open, signalling, targeting, biochem, sci,
Topics {βοΈ}
nature portfolio research development award permissions reprints privacy policy inhibit cancer-driving pathways author information authors editing mmtv-polyoma middle advertising nature 448 nature 419 nature language improvement social media phosphatidylinositol 3-kinase/akt-dependent pathway scientific publication china medical university akt-ps473 status combined prolyl isomerase pin1 serine/threonine protein kinase phosphorylated thr-pro motifs epigallocatechin-3-gallate induces apoptosis personal data springerlink instant access d3 phosphoinositide-regulated kinases dr lu kp data protection akt/pkb ser473 phosphorylation permissions multiple cancer types china akt-mtor signalling axis multiple-step process pin1 mef cells modeling breast cancer suppresses tumor growth arsenic targets pin1 alessi dr human breast cancer breast cancer patients homologue pin1 knockout testa jr privacy supplementary figure s2 supplementary figure s3 prolyl isomerase repressing pin1 expression phosphoinositide-dependent phosphorylation akt protein stability forkhead transcription factors
Questions {β}
- Targeting carcinogenesis: a role for the prolyl isomerase Pin1?
Schema {πΊοΈ}
WebPage:
mainEntity:
headline:Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation
description:The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt protein stability regulation remains unclear. In this study, we showed a strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 in multiple cancer types (P<0.0001). Akt-pS473 status combined with Pin1 expression levels predicted a poorer prognosis than did either one alone in patients with breast cancer (P=0.0052). We further showed that Pin1 regulated Akt stability and phosphorylation on S473 through the phosphorylated Thr-Pro motifs of Akt. These motifs are conserved evolutionary and are required for the maintenance of Akt stability and its interaction with Pin1. In addition, repressing Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockingdown compromised its ability to protect Akt from degradation. Our results show how Akt protein stability is regulated by the peptidyl-prolyl cis/trans isomerase Pin1 and highlight the importance of this oncogenic network in human disease pathogenesis.
datePublished:2009-05-18T00:00:00Z
dateModified:2009-05-18T00:00:00Z
pageStart:2436
pageEnd:2445
sameAs:https://doi.org/10.1038/onc.2009.98
keywords:
PKB/Akt
Pin1
peptidyl-prolyl cis/trans isomerase
breast cancer
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig5_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:28
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Y Liao
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Y Wei
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:X Zhou
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:J -Y Yang
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:C Dai
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Y -J Chen
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
type:Person
name:N K Agarwal
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:D Sarbassov
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:D Shi
affiliation:
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:D Yu
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:M -C Hung
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
name:Asia University
address:
name:Asia University, Taichung, Taiwan
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation
description:The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt protein stability regulation remains unclear. In this study, we showed a strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 in multiple cancer types (P<0.0001). Akt-pS473 status combined with Pin1 expression levels predicted a poorer prognosis than did either one alone in patients with breast cancer (P=0.0052). We further showed that Pin1 regulated Akt stability and phosphorylation on S473 through the phosphorylated Thr-Pro motifs of Akt. These motifs are conserved evolutionary and are required for the maintenance of Akt stability and its interaction with Pin1. In addition, repressing Pin1 expression through either homologue Pin1 knockout or small interfering RNA-mediated knockingdown compromised its ability to protect Akt from degradation. Our results show how Akt protein stability is regulated by the peptidyl-prolyl cis/trans isomerase Pin1 and highlight the importance of this oncogenic network in human disease pathogenesis.
datePublished:2009-05-18T00:00:00Z
dateModified:2009-05-18T00:00:00Z
pageStart:2436
pageEnd:2445
sameAs:https://doi.org/10.1038/onc.2009.98
keywords:
PKB/Akt
Pin1
peptidyl-prolyl cis/trans isomerase
breast cancer
Medicine/Public Health
general
Internal Medicine
Cell Biology
Human Genetics
Oncology
Apoptosis
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig1_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig2_HTML.gif
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig3_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig4_HTML.jpg
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_Article_BFonc200998_Fig5_HTML.jpg
isPartOf:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:28
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Y Liao
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Y Wei
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:X Zhou
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:J -Y Yang
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:C Dai
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:Y -J Chen
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
type:Person
name:N K Agarwal
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:D Sarbassov
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:D Shi
affiliation:
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
type:Person
name:D Yu
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
type:Person
name:M -C Hung
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
name:Asia University
address:
name:Asia University, Taichung, Taiwan
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:
hasPart:
isAccessibleForFree:
cssSelector:.main-content
type:WebPageElement
["Periodical","PublicationVolume"]:
name:Oncogene
issn:
1476-5594
0950-9232
volumeNumber:28
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
name:Asia University
address:
name:Asia University, Taichung, Taiwan
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Y Liao
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
email:[email protected]
name:Y Wei
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:X Zhou
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
name:J -Y Yang
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:C Dai
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Y -J Chen
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
name:N K Agarwal
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:D Sarbassov
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:D Shi
affiliation:
name:Cancer Hospital, Fudan University
address:
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
type:PostalAddress
type:Organization
name:D Yu
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:M -C Hung
affiliation:
name:The University of Texas MD Anderson Cancer Center
address:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
type:PostalAddress
type:Organization
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital
address:
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
type:PostalAddress
type:Organization
name:Asia University
address:
name:Asia University, Taichung, Taiwan
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA
name:Center for Molecular Medicine and Graduate Institute of Cancer Biology, China Medical University and Hospital, Taichung, Taiwan
name:Asia University, Taichung, Taiwan
WebPageElement:
isAccessibleForFree:
cssSelector:.main-content
External Links {π}(183)
- How much income does https://link.springer.com/article/10.1038/onc.2009.98?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle have?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=8978681 produce monthly?
- Revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC452479
- How much does http://scholar.google.com/scholar_lookup?&title=Mechanism%20of%20activation%20of%20protein%20kinase%20B%20by%20insulin%20and%20IGF-1&journal=EMBO%20J&volume=15&pages=6541-6551&publication_year=1996&author=Alessi%2CDR&author=Andjelkovic%2CM&author=Caudwell%2CB&author=Cron%2CP&author=Morrice%2CN&author=Cohen%2CP pull in monthly?
- How much profit does https://doi.org/10.1016%2FS0002-9440%2810%2963731-5 make?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15111319's revenue stream
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615639 income
- How much does http://scholar.google.com/scholar_lookup?&title=Prevalent%20overexpression%20of%20prolyl%20isomerase%20Pin1%20in%20human%20cancers&journal=Am%20J%20Pathol&doi=10.1016%2FS0002-9440%2810%2963731-5&volume=164&pages=1727-1737&publication_year=2004&author=Bao%2CL&author=Kimzey%2CA&author=Sauter%2CG&author=Sowadski%2CJM&author=Lu%2CKP&author=Wang%2CDG pull in monthly?
- Get to know https://doi.org/10.1016%2Fj.molcel.2005.03.020's earnings
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15837416's total income per month
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20Akt%2FPKB%20Ser473%20phosphorylation&journal=Mol%20Cell&doi=10.1016%2Fj.molcel.2005.03.020&volume=18&pages=143-145&publication_year=2005&author=Bayascas%2CJR&author=Alessi%2CDR
- See how much https://doi.org/10.1038%2Fsj.onc.1201947 makes per month
- Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9690513 earns monthly
- Earnings of http://scholar.google.com/scholar_lookup?&title=Akt%20activation%20by%20growth%20factors%20is%20a%20multiple-step%20process%3A%20the%20role%20of%20the%20PH%20domain&journal=Oncogene&doi=10.1038%2Fsj.onc.1201947&volume=17&pages=313-325&publication_year=1998&author=Bellacosa%2CA&author=Chan%2CTO&author=Ahmed%2CNN&author=Datta%2CK&author=Malstrom%2CS&author=Stokoe%2CD
- What's the financial intake of https://doi.org/10.1016%2FS0065-230X%2805%2994002-5?
- Find out how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16095999 earns monthly
- How profitable is http://scholar.google.com/scholar_lookup?&title=Activation%20of%20AKT%20kinases%20in%20cancer%3A%20implications%20for%20therapeutic%20targeting&journal=Adv%20Cancer%20Res&doi=10.1016%2FS0065-230X%2805%2994002-5&volume=94&pages=29-86&publication_year=2005&author=Bellacosa%2CA&author=Kumar%2CCC&author=Di%20Cristofano%2CA&author=Testa%2CJR?
- How much income does https://doi.org/10.1016%2Fj.devcel.2007.03.020 have?
- What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17419990?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=The%20two%20TORCs%20and%20Akt&journal=Dev%20Cell&doi=10.1016%2Fj.devcel.2007.03.020&volume=12&pages=487-502&publication_year=2007&author=Bhaskar%2CPT&author=Hay%2CN
- How much profit does https://doi.org/10.1016%2Fj.tibs.2004.03.006 generate?
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15130559 generate?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=Advances%20in%20protein%20kinase%20B%20signalling%3A%20AKTion%20on%20multiple%20fronts&journal=Trends%20Biochem%20Sci&doi=10.1016%2Fj.tibs.2004.03.006&volume=29&pages=233-242&publication_year=2004&author=Brazil%2CDP&author=Yang%2CZZ&author=Hemmings%2CBA?
- Earnings of https://doi.org/10.1016%2Fj.molcel.2007.02.017
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17386267 generate monthly?
- What's the profit of http://scholar.google.com/scholar_lookup?&title=PHLPP%20and%20a%20second%20isoform%2C%20PHLPP2%2C%20differentially%20attenuate%20the%20amplitude%20of%20Akt%20signaling%20by%20regulating%20distinct%20Akt%20isoforms&journal=Mol%20Cell&doi=10.1016%2Fj.molcel.2007.02.017&volume=25&pages=917-931&publication_year=2007&author=Brognard%2CJ&author=Sierecki%2CE&author=Gao%2CT&author=Newton%2CAC?
- Income figures for https://doi.org/10.1189%2Fjlb.1202629
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12773501 make?
- http://scholar.google.com/scholar_lookup?&title=Decisions%20on%20life%20and%20death%3A%20FOXO%20Forkhead%20transcription%20factors%20are%20in%20command%20when%20PKB%2FAkt%20is%20off%20duty&journal=J%20Leukoc%20Biol&doi=10.1189%2Fjlb.1202629&volume=73&pages=689-701&publication_year=2003&author=Burgering%2CBM&author=Medema%2CRH's financial summary
- Get to know what's the income of https://doi.org/10.1038%2Fnature05933
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17611497's total income per month
- What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=A%20transforming%20mutation%20in%20the%20pleckstrin%20homology%20domain%20of%20AKT1%20in%20cancer&journal=Nature&doi=10.1038%2Fnature05933&volume=448&pages=439-444&publication_year=2007&author=Carpten%2CJD&author=Faber%2CAL&author=Horn%2CC&author=Donoho%2CGP&author=Briggs%2CSL&author=Robbins%2CCM?
- How much money does https://doi.org/10.1126%2Fscience.1118947 generate?
- How much profit is http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16224021 making per month?
- How much does http://scholar.google.com/scholar_lookup?&title=Akt-mediated%20phosphorylation%20of%20EZH2%20suppresses%20methylation%20of%20lysine%2027%20in%20histone%20H3&journal=Science&doi=10.1126%2Fscience.1118947&volume=310&pages=306-310&publication_year=2005&author=Cha%2CTL&author=Zhou%2CBP&author=Xia%2CW&author=Wu%2CY&author=Yang%2CCC&author=Chen%2CCT pull in monthly?
- Get to know https://doi.org/10.1146%2Fannurev.biochem.68.1.965's earnings
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10872470 gross monthly?
- http://scholar.google.com/scholar_lookup?&title=AKT%2FPKB%20and%20other%20D3%20phosphoinositide-regulated%20kinases%3A%20kinase%20activation%20by%20phosphoinositide-dependent%20phosphorylation&journal=Annu%20Rev%20Biochem&doi=10.1146%2Fannurev.biochem.68.1.965&volume=68&pages=965-1014&publication_year=1999&author=Chan%2CTO&author=Rittenhouse%2CSE&author=Tsichlis%2CPN's revenue stream
- What are the total earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=11752635?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=PDK2%3A%20a%20complex%20tail%20in%20one%20Akt&journal=Sci%20STKE&volume=2001&publication_year=2001&author=Chan%2CTO&author=Tsichlis%2CPN?
- Get to know https://doi.org/10.1038%2Fnrc1819's earnings
- What's the monthly money flow for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16453012?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=Beyond%20PTEN%20mutations%3A%20the%20PI3%E2%80%89K%20pathway%20as%20an%20integrator%20of%20multiple%20inputs%20during%20tumorigenesis&journal=Nat%20Rev%20Cancer&doi=10.1038%2Fnrc1819&volume=6&pages=184-192&publication_year=2006&author=Cully%2CM&author=You%2CH&author=Levine%2CAJ&author=Mak%2CTW?
- https://doi.org/10.1038%2Fsj.onc.1210202's total income per month
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17322919 net monthly?
- What's the revenue for http://scholar.google.com/scholar_lookup?&title=The%20phosphatidyl%20inositol%203-kinase%20signaling%20network%3A%20implications%20for%20human%20breast%20cancer&journal=Oncogene&doi=10.1038%2Fsj.onc.1210202&volume=26&pages=1338-1345&publication_year=2007&author=Dillon%2CRL&author=White%2CDE&author=Muller%2CWJ?
- How much revenue does https://doi.org/10.1038%2Fsj.onc.1209099 generate?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16288287 pull in monthly?
- How much income does http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20the%20Akt%20kinase%20by%20interacting%20proteins&journal=Oncogene&doi=10.1038%2Fsj.onc.1209099&volume=24&pages=7401-7409&publication_year=2005&author=Du%2CK&author=Tsichlis%2CPN have?
- How much income is https://doi.org/10.1042%2FBST0350231 earning monthly?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17371246 pull in monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Physiological%20roles%20of%20PKB%2FAkt%20isoforms%20in%20development%20and%20disease&journal=Biochem%20Soc%20Trans&doi=10.1042%2FBST0350231&volume=35&pages=231-235&publication_year=2007&author=Dummler%2CB&author=Hemmings%2CBA net monthly?
- What's the income of https://doi.org/10.1038%2Femboj.2008.120?
- How much cash flow does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18566586 have monthly?
- How much income does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486276 have?
- What's the monthly income of http://scholar.google.com/scholar_lookup?&title=The%20mammalian%20target%20of%20rapamycin%20complex%202%20controls%20folding%20and%20stability%20of%20Akt%20and%20protein%20kinase%20C&journal=EMBO%20J&doi=10.1038%2Femboj.2008.120&volume=27&pages=1932-1943&publication_year=2008&author=Facchinetti%2CV&author=Ouyang%2CW&author=Wei%2CH&author=Soto%2CN&author=Lazorchak%2CA&author=Gould%2CC?
- What's the income generated by https://doi.org/10.2174%2F156800908784293622 each month?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18473735 earn?
- How much does http://scholar.google.com/scholar_lookup?&title=Phosphorylation-specific%20prolyl%20isomerase%20Pin1%20as%20a%20new%20diagnostic%20and%20therapeutic%20target%20for%20cancer&journal=Curr%20Cancer%20Drug%20Targets&doi=10.2174%2F156800908784293622&volume=8&pages=223-229&publication_year=2008&author=Finn%2CG&author=Lu%2CKP generate monthly?
- How much does https://doi.org/10.1016%2Fj.molcel.2005.03.008 earn?
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15808505 generate?
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=PHLPP%3A%20a%20phosphatase%20that%20directly%20dephosphorylates%20Akt%2C%20promotes%20apoptosis%2C%20and%20suppresses%20tumor%20growth&journal=Mol%20Cell&doi=10.1016%2Fj.molcel.2005.03.008&volume=18&pages=13-24&publication_year=2005&author=Gao%2CT&author=Furnari%2CF&author=Newton%2CAC
- Earnings of https://doi.org/10.1016%2Fj.molmed.2005.06.007
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16002336
- What's http://scholar.google.com/scholar_lookup?&title=An%20expanding%20role%20for%20mTOR%20in%20cancer&journal=Trends%20Mol%20Med&doi=10.1016%2Fj.molmed.2005.06.007&volume=11&pages=353-361&publication_year=2005&author=Guertin%2CDA&author=Sabatini%2CDM's gross income?
- Learn how profitable https://doi.org/10.1038%2Femboj.2008.119 is on a monthly basis
- What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18566587?
- Revenue of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486275
- How much does http://scholar.google.com/scholar_lookup?&title=Essential%20function%20of%20TORC2%20in%20PKC%20and%20Akt%20turn%20motif%20phosphorylation%2C%20maturation%20and%20signalling&journal=EMBO%20J&doi=10.1038%2Femboj.2008.119&volume=27&pages=1919-1931&publication_year=2008&author=Ikenoue%2CT&author=Inoki%2CK&author=Yang%2CQ&author=Zhou%2CX&author=Guan%2CKL pull in?
- Profit of https://doi.org/10.1073%2Fpnas.0408864102
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15647370 make?
- Explore the financials of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC545580
- How much profit does http://scholar.google.com/scholar_lookup?&title=Phosphatidylinositol%203-kinase%20mutations%20identified%20in%20human%20cancer%20are%20oncogenic&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.0408864102&volume=102&pages=802-807&publication_year=2005&author=Kang%2CS&author=Bader%2CAG&author=Vogt%2CPK make?
- How much revenue does https://link.springer.com/doi/10.1007/s001099900050 generate?
- What are the earnings of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10569203?
- How profitable is http://scholar.google.com/scholar_lookup?&title=Forkhead%20transcription%20factors%3A%20new%20insights%20into%20protein%20kinase%20B%20%28c-akt%29%20signaling&journal=J%20Mol%20Med&doi=10.1007%2Fs001099900050&volume=77&pages=656-665&publication_year=1999&author=Kops%2CGJ&author=Burgering%2CBM?
- How much does https://doi.org/10.1128%2FMCB.23.19.6836-6848.2003 pull in?
- Explore the financials of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12972603
- How much does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC193925 pull in monthly?
- How much does http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20the%20activity%20of%20p38%20mitogen-activated%20protein%20kinase%20by%20Akt%20in%20cancer%20and%20adenoviral%20protein%20E1A-mediated%20sensitization%20to%20apoptosis&journal=Mol%20Cell%20Biol&doi=10.1128%2FMCB.23.19.6836-6848.2003&volume=23&pages=6836-6848&publication_year=2003&author=Liao%2CY&author=Hung%2CMC gross monthly?
- What is the earnings of https://doi.org/10.1073%2Fpnas.060025397?
- What's the financial gain of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10759547?
- How much money does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC18221 make?
- What's the financial gain of http://scholar.google.com/scholar_lookup?&title=Beta-catenin%2C%20a%20novel%20prognostic%20marker%20for%20breast%20cancer%3A%20its%20roles%20in%20cyclin%20D1%20expression%20and%20cancer%20progression&journal=Proc%20Natl%20Acad%20Sci%20USA&doi=10.1073%2Fpnas.060025397&volume=97&pages=4262-4266&publication_year=2000&author=Lin%2CSY&author=Xia%2CW&author=Wang%2CJC&author=Kwong%2CKY&author=Spohn%2CB&author=Wen%2CY?
- What is the earnings of https://doi.org/10.1002%2Fmc.20216?
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16652378 bring in?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Targeting%20carcinogenesis%3A%20a%20role%20for%20the%20prolyl%20isomerase%20Pin1%3F&journal=Mol%20Carcinog&doi=10.1002%2Fmc.20216&volume=45&pages=397-402&publication_year=2006&author=Lu%2CKP&author=Suizu%2CF&author=Zhou%2CXZ&author=Finn%2CG&author=Lam%2CP&author=Wulf%2CG?
- How much revenue does https://doi.org/10.1038%2Fnrm2261 generate?
- See how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17878917 makes per month
- How much does http://scholar.google.com/scholar_lookup?&title=The%20prolyl%20isomerase%20PIN1%3A%20a%20pivotal%20new%20twist%20in%20phosphorylation%20signalling%20and%20disease&journal=Nat%20Rev%20Mol%20Cell%20Biol&doi=10.1038%2Fnrm2261&volume=8&pages=904-916&publication_year=2007&author=Lu%2CKP&author=Zhou%2CXZ earn?
- What's the income generated by https://doi.org/10.1126%2Fscience.283.5406.1325 each month?
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10037602?
- Financial intake of http://scholar.google.com/scholar_lookup?&title=Function%20of%20WW%20domains%20as%20phosphoserine-%20or%20phosphothreonine-binding%20modules&journal=Science&doi=10.1126%2Fscience.283.5406.1325&volume=283&pages=1325-1328&publication_year=1999&author=Lu%2CPJ&author=Zhou%2CXZ&author=Shen%2CM&author=Lu%2CKP
- How much cash flow does https://doi.org/10.1016%2FS1535-6108%2803%2900248-4 have monthly?
- What's the revenue for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=14585353?
- How much does http://scholar.google.com/scholar_lookup?&title=Targeting%20the%20PI3K-Akt%20pathway%20in%20human%20cancer%3A%20rationale%20and%20promise&journal=Cancer%20Cell&doi=10.1016%2FS1535-6108%2803%2900248-4&volume=4&pages=257-262&publication_year=2003&author=Luo%2CJ&author=Manning%2CBD&author=Cantley%2CLC earn?
- Get to know https://doi.org/10.1016%2Fj.cell.2007.06.009's earnings
- How much profit does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17604717 generate?
- What's the income of http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756685?
- How much cash flow does http://scholar.google.com/scholar_lookup?&title=AKT%2FPKB%20signaling%3A%20navigating%20downstream&journal=Cell&doi=10.1016%2Fj.cell.2007.06.009&volume=129&pages=1261-1274&publication_year=2007&author=Manning%2CBD&author=Cantley%2CLC have monthly?
- How much does https://doi.org/10.1158%2F0008-5472.CAN-06-3782 earn?
- What's the financial outcome of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17210696?
- How much money does http://scholar.google.com/scholar_lookup?&title=Akt1%20ablation%20inhibits%2C%20whereas%20Akt2%20ablation%20accelerates%2C%20the%20development%20of%20mammary%20adenocarcinomas%20in%20mouse%20mammary%20tumor%20virus%20%28MMTV%29-ErbB2%2Fneu%20and%20MMTV-polyoma%20middle%20T%20transgenic%20mice&journal=Cancer%20Res&doi=10.1158%2F0008-5472.CAN-06-3782&volume=67&pages=167-177&publication_year=2007&author=Maroulakou%2CIG&author=Oemler%2CW&author=Naber%2CSP&author=Tsichlis%2CPN generate?
- https://doi.org/10.1074%2Fjbc.273.45.29864's financial summary
- What's the monthly income of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=9792703?
- How much income is http://scholar.google.com/scholar_lookup?&title=Cyclin%20D%20expression%20is%20controlled%20post-transcriptionally%20via%20a%20phosphatidylinositol%203-kinase%2FAkt-dependent%20pathway&journal=J%20Biol%20Chem&doi=10.1074%2Fjbc.273.45.29864&volume=273&pages=29864-29872&publication_year=1998&author=Muise-Helmericks%2CR&author=Grimes%2CHL&author=Bellacosa%2CA&author=Malstrom%2CSE&author=Tsichlis%2CPN earning monthly?
- What's the total monthly financial gain of https://doi.org/10.1042%2Fbj20021626?
- What is the monthly revenue of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12495431?
- How much revenue does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223206 generate?
- Get to know what's the income of http://scholar.google.com/scholar_lookup?&title=Regulation%20of%20ABC%20kinases%20by%20phosphorylation%3A%20protein%20kinase%20C%20as%20a%20paradigm&journal=Biochem%20J&doi=10.1042%2Fbj20021626&volume=370&pages=361-371&publication_year=2003&author=Newton%2CAC
- How much income does https://doi.org/10.1126%2Fscience.1106148 have?
- What's the revenue for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15718470?
- How much profit does http://scholar.google.com/scholar_lookup?&title=Phosphorylation%20and%20regulation%20of%20Akt%2FPKB%20by%20the%20rictor-mTOR%20complex&journal=Science&doi=10.1126%2Fscience.1106148&volume=307&pages=1098-1101&publication_year=2005&author=Sarbassov%2CDD&author=Guertin%2CDA&author=Ali%2CSM&author=Sabatini%2CDM generate?
- Learn how profitable https://doi.org/10.1159%2F000096289 is on a monthly basis
- See how much http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17047397 makes per month
- Explore the financials of http://scholar.google.com/scholar_lookup?&title=Mutational%20analysis%20of%20AKT1%2C%20AKT2%20and%20AKT3%20genes%20in%20common%20human%20carcinomas&journal=Oncology&doi=10.1159%2F000096289&volume=70&pages=285-289&publication_year=2006&author=Soung%2CYH&author=Lee%2CJW&author=Nam%2CSW&author=Lee%2CJY&author=Yoo%2CNJ&author=Lee%2CSH
- Earnings of https://link.springer.com/doi/10.1007/s00018-007-7270-0
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17965833 income
- See how much http://scholar.google.com/scholar_lookup?&title=Prolyl%20isomerase%2C%20Pin1%3A%20new%20findings%20of%20post-translational%20modifications%20and%20physiological%20substrates%20in%20cancer%2C%20asthma%20and%20Alzheimer%2Fs%20disease&journal=Cell%20Mol%20Life%20Sci&doi=10.1007%2Fs00018-007-7270-0&volume=65&pages=359-375&publication_year=2008&author=Takahashi%2CK&author=Uchida%2CC&author=Shin%2CRW&author=Shimazaki%2CK&author=Uchida%2CT makes per month
- How much revenue does https://doi.org/10.1038%2Fsj.onc.1209100 bring in?
- Check the income stats for http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16288285
- How much money does http://scholar.google.com/scholar_lookup?&title=AKT%20signaling%20in%20normal%20and%20malignant%20cells&journal=Oncogene&doi=10.1038%2Fsj.onc.1209100&volume=24&pages=7391-7393&publication_year=2005&author=Testa%2CJR&author=Tsichlis%2CPN make?
- What's the income generated by https://doi.org/10.2174%2F156800908783497140 each month?
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18288941's total income per month
- Learn about the earnings of http://scholar.google.com/scholar_lookup?&title=Deregulation%20of%20the%20Akt%20pathway%20in%20human%20cancer&journal=Curr%20Cancer%20Drug%20Targets&doi=10.2174%2F156800908783497140&volume=8&pages=27-36&publication_year=2008&author=Tokunaga%2CE&author=Oki%2CE&author=Egashira%2CA&author=Sadanaga%2CN&author=Morita%2CM&author=Kakeji%2CY
- What's the profit of https://doi.org/10.1038%2Fsj.emboj.7600323?
- How much income does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15257284 have?
- How much money does http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514501 make?
- What are the total earnings of http://scholar.google.com/scholar_lookup?&title=Modeling%20breast%20cancer%20in%20vivo%20and%20ex%20vivo%20reveals%20an%20essential%20role%20of%20Pin1%20in%20tumorigenesis&journal=EMBO%20J&doi=10.1038%2Fsj.emboj.7600323&volume=23&pages=3397-3407&publication_year=2004&author=Wulf%2CG&author=Garg%2CP&author=Liou%2CYC&author=Iglehart%2CD&author=Lu%2CKP?
- How much income does https://doi.org/10.1158%2F1078-0432.CCR-03-0527 have?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15173090 make?
- What's the income of http://scholar.google.com/scholar_lookup?&title=Phosphorylation%2Fcytoplasmic%20localization%20of%20p21Cip1%2FWAF1%20is%20associated%20with%20HER2%2Fneu%20overexpression%20and%20provides%20a%20novel%20combination%20predictor%20for%20poor%20prognosis%20in%20breast%20cancer%20patients&journal=Clin%20Cancer%20Res&doi=10.1158%2F1078-0432.CCR-03-0527&volume=10&pages=3815-3824&publication_year=2004&author=Xia%2CW&author=Chen%2CJS&author=Zhou%2CX&author=Sun%2CPR&author=Lee%2CDF&author=Liao%2CY?
- https://doi.org/10.1042%2Fbst0320350 income
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15046607's total income per month
- How much profit is http://scholar.google.com/scholar_lookup?&title=Physiological%20functions%20of%20protein%20kinase%20B%2FAkt&journal=Biochem%20Soc%20Trans&doi=10.1042%2Fbst0320350&volume=32&pages=350-354&publication_year=2004&author=Yang%2CZZ&author=Tschopp%2CO&author=Baudry%2CA&author=Dummler%2CB&author=Hynx%2CD&author=Hemmings%2CBA making per month?
- How much revenue does https://doi.org/10.1038%2Fncb1110 produce monthly?
- Profit of http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15048125
- Discover the revenue of http://scholar.google.com/scholar_lookup?&title=A%20signalling%20pathway%20controlling%20c-Myc%20degradation%20that%20impacts%20oncogenic%20transformation%20of%20human%20cells&journal=Nat%20Cell%20Biol&doi=10.1038%2Fncb1110&volume=6&pages=308-318&publication_year=2004&author=Yeh%2CE&author=Cunningham%2CM&author=Arnold%2CH&author=Chasse%2CD&author=Monteith%2CT&author=Ivaldi%2CG
- Learn how profitable https://doi.org/10.1038%2Fnrc2107 is on a monthly basis
- How much revenue does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17410202 generate?
- How much does http://scholar.google.com/scholar_lookup?&title=PIN1%2C%20the%20cell%20cycle%20and%20cancer&journal=Nat%20Rev%20Cancer&doi=10.1038%2Fnrc2107&volume=7&pages=381-388&publication_year=2007&author=Yeh%2CES&author=Means%2CAR generate monthly?
- How profitable is https://doi.org/10.1038%2Fnature01120?
- How much does http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=12397362 gross monthly?
- What's http://scholar.google.com/scholar_lookup?&title=The%20prolyl%20isomerase%20Pin1%20reveals%20a%20mechanism%20to%20control%20p53%20functions%20after%20genotoxic%20insults&journal=Nature&doi=10.1038%2Fnature01120&volume=419&pages=853-857&publication_year=2002&author=Zacchi%2CP&author=Gostissa%2CM&author=Uchida%2CT&author=Salvagno%2CC&author=Avolio%2CF&author=Volinia%2CS's gross income?
- How much profit does https://citation-needed.springer.com/v2/references/10.1038/onc.2009.98?format=refman&flavour=references make?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y%20Liao gross monthly?
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y%20Liao%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en bring in?
- How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y%20Wei rake in every month?
- Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y%20Wei%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- What's the revenue for https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=X%20Zhou?
- What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22X%20Zhou%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Financial intake of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=J%20-Y%20Yang
- Learn how profitable https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22J%20-Y%20Yang%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en is on a monthly basis
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=C%20Dai's financial summary
- How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22C%20Dai%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en gross monthly?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Y%20-J%20Chen produce monthly?
- Monthly income for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Y%20-J%20Chen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=N%20K%20Agarwal
- How much revenue does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22N%20K%20Agarwal%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=D%20Sarbassov's financial summary
- Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22D%20Sarbassov%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
- What is the monthly revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=D%20Shi?
- Income figures for https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22D%20Shi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
- How much profit does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=D%20Yu generate?
- How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22D%20Yu%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en generate?
- How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=M%20-C%20Hung bring in?
- What is the earnings of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22M%20-C%20Hung%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
- Revenue of https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM11_ESM.jpg
- What's the revenue for https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM12_ESM.jpg?
- How much profit is https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM13_ESM.jpg making per month?
- How much does https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM14_ESM.jpg pull in monthly?
- https://static-content.springer.com/esm/art%3A10.1038%2Fonc.2009.98/MediaObjects/41388_2009_BFonc200998_MOESM15_ESM.jpg's revenue stream
- https://s100.copyright.com/AppDispatchServlet?title=Peptidyl-prolyl%20cis%2Ftrans%20isomerase%20Pin1%20is%20critical%20for%20the%20regulation%20of%20PKB%2FAkt%20stability%20and%20activation%20phosphorylation&author=Y%20Liao%20et%20al&contentID=10.1038%2Fonc.2009.98©right=Macmillan%20Publishers%20Limited&publication=0950-9232&publicationDate=2009-05-18&publisherName=SpringerNature&orderBeanReset=true's financial summary
- What is the earnings of https://citation-needed.springer.com/v2/references/10.1038/onc.2009.98?format=refman&flavour=citation?
- What are the total earnings of https://doi.org/10.1186/s13045-021-01137-8?
- Financial intake of https://doi.org/10.1038/s41598-021-88478-z
- https://doi.org/10.1186/s13045-018-0611-7's financial summary
- How much does https://doi.org/10.1038/s41467-018-05402-2 rake in every month?
- How much revenue does https://doi.org/10.1038/srep43639 bring in?
- Profit of https://www.protocols.io/
- https://www.natureindex.com/'s financial summary
- What's the income of http://www.naturechina.com?
- Learn about the earnings of https://www.natureasia.com/ja-jp
Analytics and Tracking {π}
- Google Tag Manager
Libraries {π}
- Prism.js
- Zoom.js
Emails and Hosting {βοΈ}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk
CDN Services {π¦}
- Crossref