
NCBI . NLM . NIH . GOV {
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Title[redir]:
Mechanism of activation of protein kinase B by insulin and IGF-1 - PMC
Description:
Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12-fold in L6 myotubes, while after transfection into 293 cells PKBalpha was activated 20- and 50-fold in response to insulin and IGF-1 respectively. In both ...
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Keywords {🔍}
doi, kinase, pubmed, google, scholar, pmc, protein, article, free, phosphorylation, nlm, activation, insulin, embo, cells, pkbalpha, proc, natl, acad, sci, pnas, ncbi, search, hemmings, activity, biol, domain, jtbx, cohen, ser, phosphatidylinositol, image, cloning, biochem, akt, oct, thr, references, chem, pleckstrin, homology, binding, molecular, nov, site, dec, igf, alessi, cron, activated,
Topics {✒️}
rapamycin-induced p70s6k inactivation protein-serine/threonine kinases pmc beta search serine/threonine protein kinase t-cell erythrocyte receptor membrane-targeted phosphoinositide 3-kinase mitogen-activated protein kinase pdgf-activated phosphatidylinositol 3-kinase kinase signal transduction putative oncogene encoding site-directed mutagenesis rac protein kinase license information pmcid pleckstrin homology domain dual specificity enzyme protein kinase encoded pmc disclaimer glycogen synthase kinase-3 map kinase homologue ser/thr kinase kinase cascade triggered rac/akt kinase protein phosphatase inhibitors akt-1 protein kinase united states government human ovarian carcinomas polymerase chain reaction beta gamma subunits conserved hydrophobic domain stably transforming cells akt proto-oncogene insulin/igf-1-stimulated cells rac-pk/pkb protein-dye binding human pancreatic cells article image stimulates mapkap kinase-2 rapid immunoselection procedure l6 muscle cells high-affinity binding articles links phosphorylation sites required mol cell biol mutant pkbalpha molecules search log article 6547 selected references complete list binding site vivo phosphorylation sites
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